Báo cáo y học: " The HTLV-1 Tax interactome" potx
Báo cáo y học: "The elusive yeast interactome" doc
... Finally, identify all the proteins in the purified complex by mass spectrometry [5]. Then repeat this proce- dure for all the protein-coding genes in the yeast genome. This is exactly what the two teams ... comprehensive, they were by no means saturated. In fact, we estimate that only about 20% of the yeast genome has been used as baits and exhaustively screened by two-hybrid meth...
Ngày tải lên: 14/08/2014, 16:21
Báo cáo y học: " The ARDS Support Center" potx
... the information at the layperson’s level, and they have succeeded in simplifying relatively complex topics to the extent possible. Information is also provided on the many physical, cognitive, ... their families. Here, patrons relate their stories, offer support, and ask for help with the complex and multidisciplinary recovery after discharge from the ICU. We found especially nota...
Ngày tải lên: 12/08/2014, 19:22
Báo cáo y học: "The challenge of sepsis" potx
... sepsis, thereby reducing mortality from sepsis by 25% over 5 years. An unprecedented 11 organizations sponsored the evidence-based and expert opinion guidelines. Another of the stated goals of the ... management. Unfortunately, clinicians change very slowly. Historically, transfer of research from the bench to the bedside is a long, tortuous process – one that is not driven by anyth...
Ngày tải lên: 12/08/2014, 20:20
Báo cáo y học: " The HTLV-1 Tax interactome" potx
... immortalization of T- lymphocytes by HTLV-1 and plays a primary role in the development of humoral hypercalcemia of malignancy that occurs in the majority of patients with ATL [86,87]. Tax1 further associates ... Mechanistically, Tax1 enhances the dimerization of CREB/ATF factors, increases their affinity for the viral CRE [33-36] and further stabi- lizes the ternary complex th...
Ngày tải lên: 13/08/2014, 05:21
Báo cáo y học: "In vitro nuclear interactome of the HIV-1 Tat protein" pps
... complexes with histone deacetylase activity. J Biol Chem 2003, 278:42560-42568. 213. Yao YL, Yang WM, Seto E: Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol ... latency and suggests how Tat might intersect with epigenetic pathways. Alternatively, the enzymatic activities of the multi-protein complexes recruited by Tat, such as methylation, acetyla-...
Ngày tải lên: 12/08/2014, 23:21
Báo cáo y học: "HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex" pdf
... analysis. Cloning mutant tax alleles into a lentiviral vector The lentivirus vector, LV -Tax- SV-Puro, which contains the wild-type tax gene under the control of the CMV enhancer promoter and the ... 1 in the various tax- transduced cells correlated with their extent of growth arrest or lack thereof, with wild-type tax greatly increasing (A) A summary of amino acid substit...
Ngày tải lên: 13/08/2014, 05:22
Báo cáo y học: "The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix" pptx
... explanation for the enhancement of CDK4 kinase activity induced by a synthetic N-terminal Tax peptide [39]. Furthermore, this may explain the increased affinity of cyclin to CDK in the presence of Tax [36]. ... together, these findings suggest that Tax stimulates G1- to S-phase transition by supporting the association of CDK4 and cyclin D2. Fur- thermore, they support the conc...
Ngày tải lên: 13/08/2014, 09:21
Báo cáo y học: "The expanding role of Tax in transcription" pdf
... observed when Tax and Gal4-TBP were present. Interestingly, only the Tax- responsive promoters, i.e. HTLV-I and HIV-1, were both synergistically stimulated by the addition of Tax and Gal4-TBP. These results ... Tax transactivation of the HTLV-I promoter [12]. Therefore, there is the possibility that other kinase complexes (small vs. large pTEFb complex or other cdk kinases) may...
Ngày tải lên: 13/08/2014, 13:20
Báo cáo y học: "The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study"
... identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in ... and they would be missed if SIRS were used as the only way to identify infected patients. If the main pur- pose was to identify patients with a high risk of mortality, the question is w...
Ngày tải lên: 25/10/2012, 09:56
Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... difficulties” was the most used Index- category in the “all other” group with nearly 5% of the total. Approximately half of all patients in the youngest age group had “all other” medical problems ... S29 (34) Other musculoskeletal symptoms L29 (396) Other 465 10 2.3 10 400 Endocrine/metabolic symptoms T29 (11) Urinary/male genital symptoms U29 (7) Y2 9 (5) Pregnancy/female genital sy...
Ngày tải lên: 25/10/2012, 09:56