Báo cáo y học: " The HTLV-1 Tax interactome" potx
Báo cáo y học: "The elusive yeast interactome" doc
... Finally, identify all the proteins in the purified
complex by mass spectrometry [5]. Then repeat this proce-
dure for all the protein-coding genes in the yeast genome.
This is exactly what the two teams ... comprehensive,
they were by no means saturated. In fact, we estimate that
only about 20% of the yeast genome has been used as baits
and exhaustively screened by two-hybrid meth...
Báo cáo y học: " The ARDS Support Center" potx
... the information at the layperson’s level, and
they have succeeded in simplifying relatively complex topics
to the extent possible. Information is also provided on the
many physical, cognitive, ... their families. Here, patrons relate their stories, offer
support, and ask for help with the complex and
multidisciplinary recovery after discharge from the ICU. We
found especially nota...
Báo cáo y học: "The challenge of sepsis" potx
... sepsis,
thereby reducing mortality from sepsis by 25% over
5 years. An unprecedented 11 organizations sponsored the
evidence-based and expert opinion guidelines. Another of
the stated goals of the ... management.
Unfortunately, clinicians change very slowly. Historically,
transfer of research from the bench to the bedside is a
long, tortuous process – one that is not driven by anyth...
Báo cáo y học: " The HTLV-1 Tax interactome" potx
... immortalization of T-
lymphocytes by HTLV-1 and plays a primary role in the
development of humoral hypercalcemia of malignancy
that occurs in the majority of patients with ATL [86,87].
Tax1 further associates ... Mechanistically, Tax1
enhances the dimerization of CREB/ATF factors, increases
their affinity for the viral CRE [33-36] and further stabi-
lizes the ternary complex th...
Báo cáo y học: "In vitro nuclear interactome of the HIV-1 Tat protein" pps
... complexes with histone deacetylase
activity. J Biol Chem 2003, 278:42560-42568.
213. Yao YL, Yang WM, Seto E: Regulation of transcription factor
YY1 by acetylation and deacetylation. Mol Cell Biol ... latency and suggests how Tat
might intersect with epigenetic pathways.
Alternatively, the enzymatic activities of the multi-protein
complexes recruited by Tat, such as methylation, acetyla-...
Báo cáo y học: "HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex" pdf
... analysis.
Cloning mutant tax alleles into a lentiviral vector
The lentivirus vector, LV -Tax- SV-Puro, which contains the
wild-type tax gene under the control of the CMV enhancer
promoter and the ... 1
in the various tax-
transduced cells correlated with their extent of growth
arrest or lack thereof, with wild-type tax greatly increasing
(A) A summary of amino acid substit...
Báo cáo y học: "The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix" pptx
... explanation for
the enhancement of CDK4 kinase activity induced by a
synthetic N-terminal Tax peptide [39]. Furthermore, this
may explain the increased affinity of cyclin to CDK in the
presence of Tax [36]. ... together, these findings
suggest that Tax stimulates G1- to S-phase transition by
supporting the association of CDK4 and cyclin D2. Fur-
thermore, they support the conc...
Báo cáo y học: "The expanding role of Tax in transcription" pdf
... observed
when Tax and Gal4-TBP were present. Interestingly, only
the Tax- responsive promoters, i.e. HTLV-I and HIV-1, were
both synergistically stimulated by the addition of Tax and
Gal4-TBP. These results ... Tax
transactivation of the HTLV-I promoter [12]. Therefore,
there is the possibility that other kinase complexes (small
vs. large pTEFb complex or other cdk kinases) may...
Báo cáo y học: "The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study"
... identified by two or more symptoms
including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The
relationship between SIRS symptoms and morbidity and mortality in ... and they would be missed if SIRS were used as
the only way to identify infected patients. If the main pur-
pose was to identify patients with a high risk of mortality,
the question is w...
Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... difficulties” was the most used Index-
category in the “all other” group with nearly 5% of the
total. Approximately half of all patients in the youngest
age group had “all other” medical problems ... S29 (34)
Other musculoskeletal symptoms L29 (396)
Other 465 10 2.3 10 400
Endocrine/metabolic symptoms T29 (11)
Urinary/male genital symptoms U29 (7) Y2 9 (5)
Pregnancy/female genital sy...