Báo cáo y học: " Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements" pot

... of APOBEC3 proteins on bona fide exogenous retroviruses on the onehand and intracellular retroelements on the other.Results and discussion Restriction of murine and human infectious ERVs by ... similar effects take place at the level of endog-enous retroviruses with an extracellular life cycle, with an unambiguous restriction of the murine IAPE by a murine APOBEC3 protein, and of the human ... G418resistance after integration.Traces of APOBEC3 past activity on resident IAPE and HERV-K elements in the murine and human genomeSince the murine IAPE- D and the human HERV-K ele-ments are...

Báo cáo Y học: The C-terminal domain of perfringolysin O is an essential cholesterol-binding unit targeting to cholesterol-rich microdomains pptx

... separated by Tricine-SDS/PAGE and analyzed by Western blotting with an antibody against h-toxin C-terminal peptide. In the lower panel the 3D structures of T2¢ and D4 are shown in blackagainst a gray ... frac-tion (T), and the resulting supernatant (S) and pellet (P) fractions wereseparated and analyzed by SDS/PAGE followed by immunoblotting with an antibody against h-toxin C-terminal peptide. Lane ... Interaction of theta-toxin (perfringolysin O), a cholesterol-binding cytolysin, with liposomal membranes: change in the aro-matic side chains upon binding and insertion. Biochemistry 34,6513–6520.26....

Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc

... the initial analysis and can therefore not be considered to be inde-pendent from each other. Nonetheless, in order to obtain an indication of the validity of the P values obtained in these anal-yses, ... noncriticalpositions and will not completely abolish but only slightly mod-ify binding to the other proteins. The rs729749 SNP is located in the middle part of intron 4 in NCF4. By studying the genome ... studies investigating the potential roleplayed by reduced reactive oxygen species production in human RA have yet been reported. In order to examine the role played by the NOX complex in RA, we investigated...

Báo cáo y học: "What does the marriage of Open Access with online publication bring" docx

... prevention efforts in the spread of HIV-1 can tame the scourge considerably.Dissemination of the latest knowledge in basic science and its application to AIDS therapy and prevention is of paramount ... progress and survival of human kind. Let the wheel of communica-tion roll at the fastest pace and to the widest possibleworld.References1. Oppenheimer JR: Science and Common Understanding, Simon and ... cost savings for libraries and institutions in terms of the high subscription rates and archival of the oldjournals.AIDS Research and Therapy will encompass all aspects of basic and clinical...

Báo cáo y học: "Phase I safety study of 0.5% PRO 2000 vaginal Gel among HIV un-infected women in Pune, India" potx

... clinical examination was performed on day 7. Product use was continued for 7 more days and the final clinical examination and colposcopy were per-formed on day 14.During pelvic examination, ... accelerated in India through commit-ment at the policy and program management levels and by increasing involvement of institutions and non-gov-ernmental organizations. The necessary infrastructuresuch ... of Allergy and Infectious Diseases, National Institutes of Health and 6 The National Institute of Allergy and Infectious Diseases, National Institutes of Health and Johns Hopkins University...

Báo cáo y học: " Unilateral, trifocal, diaphyseal fracture of the radius with ipsilateral mid-shaft ulna fracture in an adult: a case report" doc

... fracture of the ulna in a 53-year-old Caucasian, British, right-hand dominant woman involved in a head -on collision with another vehicle. The management of this rare fracture configuration is described ... forearm in an above-elbow back slab(anteroposterior and lateral views from the initial injury).Figure 2 Open reduction and internal fixati on of left radius and ulna with dynamic compression plating ... fractures of both bones, but only bifocal injuries(that is, involving two points of fracture along a singlebone) [1]. No classification system as yet has describedthis particular type of injury.Our...

Báo cáo y học: " Left hepatic trisectionectomy for hilar cholangiocarcinoma presenting with an aberrant biliary duct of segment 5: a case report" pps

... aware of these ductal variants in left lateral sectorectomy and leftlobectomy. B2 and B3 [5] and B5 and B8 [7], separatelyjoining to the common bile duct, were reported in a liv-ing donor liver ... transplantation. In terms of the preoperative recognition of bile-ductanatomy, multi-detector computed tomography scan-ning after drip infusion cholangiography and magneticresonance cholangiography ... regarding the biliary anatomy. AN performed the operation and was a major contributor to writing the manuscript. All authors read and approved the final manuscript.Competing interests The authors...

Báo cáo y học: "Left hepatic trisectionectomy for hilar cholangiocarcinoma presenting with an aberrant biliary duct of segment 5: a case report" doc

... sectorectomy and leftlobectomy. B2 and B3 [5] and B5 and B8 [7], separatelyjoining to the common bile duct, were reported in a liv-ing donor liver transplantation. In terms of the preoperative ... regarding the biliary anatomy. AN performed the operation and was a major contributor to writing the manuscript. All authors read and approved the final manuscript.Competing interests The authors ... Correspondence: yasusuga-tky@umin.ac.jp2Artificial Organ and Transplantation Division, Department of Surgery,Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku,Tokyo 113-8655,...

Báo cáo y học: "Five-year follow-up of Japanese patients with Paget''''s disease of the bone after treatment with low-dose oral alendronate: a case series/" ppt

... disease of the bone by using low-dose oral alendronate (5 mg per day) and observed them over the five-year fol-low-up period. KI, JT, TW and TY analyzed and interpreted our patient data and the ... maintained for one and a halfyears without any further treatment. In contrast to our patient in Case 1, however, her T-ALP and uNTX levels again increased beyond the normalrange, accompanied ... decreased and her bonepain improved within a few months, and this remission in T-ALP level, uNTX level and bone pain was maintainedfor more than one year. A year after the second course of treatment,...

Báo cáo y học: "A randomised controlled comparison of early post-pyloric versus early gastric feeding to meet nutritional targets in ventilated intensive care patients" ppsx

... Benefits of enteral feeding may include improve-ments in intestinal structure and function, prevention of bacterial translocation and infective complications with lowermorbidity and cost [5-7]. There ... majority of patients, potentiallyreducing delays in the initiation of feeds.Competing interests The authors declare that they have no competing interests.Authors' contributionsHW and KS conceived, ... Lopez-Martinez J: Multicenter, prospective, randomized,single-blind study comparing the efficacy and gastrointestinalcomplications of early jejunal feeding with early gastric feed-ing in critically...

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