Báo cáo y học: " Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat" pptx

... Central Page 1 of 13 (page number not for citation purposes) Retrovirology Open Access Research Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat Caroline ... Tat- induced apoptosis [26]. Since apoptosis mediated by Tat partly relies on the interaction of Tat with tubulin [14-17], we hypoth...

Ngày tải lên: 13/08/2014, 05:21

... from airway inflammation. Conclusion: VD's modulation of airway inflammation may result from its inactivation of ERK1/2 and downregulation of NPRA expression. Chitosan nanoparticles containing ... Downregulation of NPRA expression was also confirmed both in vitro and in vivo by western blot and RT-PCR. Therefore, the observed attenuation of airway inflammation by VD is...

Ngày tải lên: 12/08/2014, 14:20

... are2D::HIS3MX6 This study MLY20 YPH499 HIS3MX6-pGAL1-ARE2-9myc-klTRP1 This study MLY21 YPH499 are1D::HIS3MX6 ste20D::klTRP1 This study MLY28 YPH499 HIS3MX6-pGAL1-ARE1-9myc-klTRP1 This study MLY84 YPH499 ... are1D::HIS3MX6 cla4D::kanMX6 This study MLY115 YPH499 ARE1-9myc-HIS3MX6 This study THY310 YPH499 ste20D::klTRP1 [25] THY609 YPH499 cla4D::kanMX6 This study THY665 YPH499 swe1D::HIS3MX6 Thi...

Ngày tải lên: 18/02/2014, 13:20

... Corresponding author Abstract Cystic Fibrosis (CF) is one of the most common autosomal genetic disorders in humans. This disease is caused by mutations within a single gene, coding for the cystic ... by NFκB. Findings Cystic Fibrosis (CF) is one of the most common lethal autosomal recessive diseases in humans. It is caused by mutations within a single gene, coding for...

Ngày tải lên: 11/08/2014, 08:22

... retro- viruses, but is C-terminally cleaved by the viral protease, leading to the production of a G ag doublet during viral replication. Moreover, FV Gag is not myristoylate d, and none of the conventional ... supernatant was used to transduce 293T cells, and GFP expression was monitored by flow cytometry forty-eight hours later. Remarkably, only the use of wild-type...

Ngày tải lên: 13/08/2014, 01:20

... absence of denaturant [44]. High-level drug resistance to TSAO is mediated by the E138K mutation in the p51 subunit of HIV-1 RT [55]. The introduction of this mutation into RT significantly diminishes ... primarily from the palm, connection and RNase H domain, while in the p51 they arise from the fingers, thumb and connection domains. Dissection of the contribution...

Ngày tải lên: 08/03/2014, 09:20

... respectively. This confirms the observed activity dependence of PEP inhibition on Ins(1,4,5)P 3 concentration. Influence of PEP inhibition on the cAMP pathway In addition to Ins(1,4,5)P 3 , the effect of ... Auerswald, E.A. (1995) Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distorted binding of the loops results in cleavage of the...

Ngày tải lên: 31/03/2014, 08:20

... This effect is consistent with the well estab- lished inhibitory effect of ALP on the cytoskeletal reorganiza- tion of stimulated granulocytes and the accompanying suppression of conformational ... postcapillary endothelium by ALP in vivoInhibition of leukocyte interaction with the postcapillary endothelium by ALP in vivo. (a) Inhibition of leukocyte rolling along...

Ngày tải lên: 09/08/2014, 08:22

... unstimulated conditions, p65 is restricted to the cytoplasm by a set of inhibitory proteins and, upon stim- ulation, translocated to the nucleus. This stimulation can be modulated by phosphorylation of ... in this study (50 ng/ml) [28]. The induction of NOS2 activity upon activation of PKC by LPS stimulation has also been demonstrated previously using a non-selec- ti...

Ngày tải lên: 11/08/2014, 08:21

... pathogens. This system is based on primed T and B lymphocytes that migrate from the site of antigen presentation via lymphat- ics and blood to selectively "home" to lymphoid tissue at distant ... gastrointestinal, respiratory, genitourinary and other mucosa-associated regions [17]. In this context, the objective of this study was to analyse humoral and cellular imm...

Ngày tải lên: 11/08/2014, 10:23