... Central
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Retrovirology
Open Access
Research
Modulation of microtubule assembly by the HIV-1 Tat protein is
strongly dependent on zinc binding to Tat
Caroline ... Tat- induced
apoptosis [26]. Since apoptosis mediated by Tat partly
relies on the interaction of Tat with tubulin [14-17], we
hypoth...
... from airway inflammation.
Conclusion: VD's modulation of airway inflammation may result from its inactivation of ERK1/2
and downregulation of NPRA expression. Chitosan nanoparticles containing ... Downregulation of
NPRA expression was also confirmed both in vitro and in
vivo by western blot and RT-PCR. Therefore, the observed
attenuation of airway inflammation by VD is...
... are2D::HIS3MX6 This study
MLY20 YPH499 HIS3MX6-pGAL1-ARE2-9myc-klTRP1 This study
MLY21 YPH499 are1D::HIS3MX6 ste20D::klTRP1 This study
MLY28 YPH499 HIS3MX6-pGAL1-ARE1-9myc-klTRP1 This study
MLY84 YPH499 ... are1D::HIS3MX6 cla4D::kanMX6 This study
MLY115 YPH499 ARE1-9myc-HIS3MX6 This study
THY310 YPH499 ste20D::klTRP1 [25]
THY609 YPH499 cla4D::kanMX6 This study
THY665 YPH499 swe1D::HIS3MX6 Thi...
... Corresponding author
Abstract
Cystic Fibrosis (CF) is one of the most common autosomal genetic disorders in humans. This
disease is caused by mutations within a single gene, coding for the cystic ... by NFκB.
Findings
Cystic Fibrosis (CF) is one of the most common lethal
autosomal recessive diseases in humans. It is caused by
mutations within a single gene, coding for...
... retro-
viruses, but is C-terminally cleaved by the viral protease,
leading to the production of a G ag doublet during viral
replication. Moreover, FV Gag is not myristoylate d, and
none of the conventional ... supernatant was used to transduce
293T cells, and GFP expression was monitored by flow
cytometry forty-eight hours later. Remarkably, only the
use of wild-type...
... absence
of denaturant [44]. High-level drug resistance to TSAO is
mediated by the E138K mutation in the p51 subunit of
HIV-1 RT [55]. The introduction of this mutation into RT
significantly diminishes ... primarily from the
palm, connection and RNase H domain, while in the p51
they arise from the fingers, thumb and connection domains.
Dissection of the contribution...
... respectively. This confirms
the observed activity dependence of PEP inhibition on
Ins(1,4,5)P
3
concentration.
Influence of PEP inhibition on the cAMP pathway
In addition to Ins(1,4,5)P
3
, the effect of ... Auerswald, E.A. (1995) Temporary inhibition of
papain by hairpin loop mutants of chicken cystatin. Distorted
binding of the loops results in cleavage of the...
... This effect is consistent with the well estab-
lished inhibitory effect of ALP on the cytoskeletal reorganiza-
tion of stimulated granulocytes and the accompanying
suppression of conformational ... postcapillary endothelium by ALP in vivoInhibition of leukocyte interaction with the postcapillary endothelium by
ALP in vivo. (a) Inhibition of leukocyte rolling along...
... unstimulated conditions, p65 is restricted to the
cytoplasm by a set of inhibitory proteins and, upon stim-
ulation, translocated to the nucleus. This stimulation can
be modulated by phosphorylation of ... in this study (50 ng/ml) [28]. The induction of
NOS2 activity upon activation of PKC by LPS stimulation
has also been demonstrated previously using a non-selec-
ti...
... pathogens. This
system is based on primed T and B lymphocytes that
migrate from the site of antigen presentation via lymphat-
ics and blood to selectively "home" to lymphoid tissue at
distant ... gastrointestinal, respiratory, genitourinary
and other mucosa-associated regions [17].
In this context, the objective of this study was to analyse
humoral and cellular imm...