... unattractively elaborate, the reductive hotspot hypothesis of mammalian aging is an extension of the long-standing mitochondrial theory that, unlike many of its predecessors, remains strikingly consis- tent ... from the accumulation of mitochondri- ally mutant cells. 2004 A. D. N. J. de Grey (Eur. J. Biochem. 269) Ó FEBS 2002 MINIREVIEW The reductive hotspot...
Ngày tải lên: 17/03/2014, 23:20
... membrane cholesterol topology – mode of binding of theta-toxin to cholesterol in liposomes. Biochim. Biophys. Acta 1109, 81–90. 13. Mobius, W., Ohno-Iwashita, Y. , van Donselaar, E.G., Oorschot, V.M.J., ... Society (to Y. S.) and from a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, ONO Medical Research Foundation and Life Science Found...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: The cold-active lipase of Pseudomonas fragi Heterologous expression, biochemical characterization and molecular modeling pdf
... peptide-independent pathway and calls for further investigation on this subject. Enzyme activity and specificity In the standard tricaprylin hydrolysis assay, rPFL displayed highest activity at 29 °C and pH 8.0, ... with the solvent [3]. Both factors are of importance for cold activity. On the other hand, the presence of disulphide bridges may increase the rigidity of th...
Ngày tải lên: 24/03/2014, 04:21
Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf
... C-terminus of the sulfonylurea receptor is important for K ATP channel function but is not key for complex assembly or trafficking Jonathan P. Giblin*, Kathryn Quinn* and Andrew Tinker Centre for Clinical ... complex. The data reported here show that the cytoplasmic C-terminus of SUR1 has a key role in channel function but is not a...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity pot
... Pungerc ˇ ar 2 1 Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia; 2 Department of Biochemistry and Molecular Biology and 3 Mass ... PRIORITY PAPER The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity Petra Prijatelj 1 , Igor Kriz ˇ aj 2 , Bogda...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo Y học: The processivity and fidelity of DNA synthesis exhibited by the reverse transcriptase of bovine leukemia virus pot
... The processivity and fidelity of DNA synthesis exhibited by the reverse transcriptase of bovine leukemia virus Orna Avidan, Michal Entin Meer, Iris Oz and Amnon Hizi Department of Cell Biology ... processivity of DNA synthesis and the fidelity of DNA synthesis. These properties were c ompared with t hose o f the well-studied RTs of...
Ngày tải lên: 31/03/2014, 21:21
Báo cáo y học: "The anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effect" pptx
... of 5 (page number not for citation purposes) Allergy, Asthma & Clinical Immunology Open Access Review The anti-inflammatory effects of levocetirizine - are they clinically relevant or just ... some of which may not be attribut- able to H1-receptor blockade. These anti-inflammatory activities are observed at clinically relevant concentra- tions, both in...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "The psychological well-being of children orphaned by AIDS in Cape Town, South Africa" pptx
... not for citation purposes) Annals of General Psychiatry Open Access Primary research The psychological well-being of children orphaned by AIDS in Cape Town, South Africa Lucie Cluver 1,2 and ... first study in South Africa, and one of the first in Africa, to use standardised questionnaires and a matched, non affected control group in measuring psychological...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "The emerging modern face of mood disorders: a didactic editorial with a detailed presentation of data and definitions" potx
... emerging modern face of mood disor- ders: a didactic editorial with a detailed presentation of data and definitions Annals of General Psychiatry 2010, 9:14 Fountoulakis Annals of General Psychiatry ... is especially true during the teenage and early adult years, relates mainly to cyclothymia and probably represents attempts at self-medication for the m...
Ngày tải lên: 08/08/2014, 23:21
Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... V H gene < /b> repertoire < /b> of < /b> splenic < /b> B cells and somatic hypermutation in systemic lupus erythematosus Nicola L W Fraser 1 , Gary Rowley 1 , Max Field 2 and David I Stott 1 1 Division of < /b> Immunology, Infection ... 1, and has two distinct areas of < /b> staining for FDC and one large area of < /b> B cells encompassing both FDC regions. V...
Ngày tải lên: 09/08/2014, 01:21
Báo cáo y học: "The use and abuse of commercial kits used to detect autoantibodies" ppsx
... high level of security, of scrutiny and of standardization, and under good labora- tory practices and quality control. Many of these compa- nies subscribe to and offer postmarketing quality assurance ... chain of production, use and application of autoantibody test kits. 198 Patient The ongoing demands of quality control and quality assur- ance are highly depe...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "The synovial proteome: analysis of fibroblast-like synoviocytes" doc
... Millatt LJ, Whitley GS, Li D, Leiper JM, Siragy HM, Carey RM, Johns RA: Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pul- monary hypertension. ... approved by the Ethics Committee of the University of Manitoba. All patients met American College of Rheumatology criteria. FLS cells were isolated as previously described [15]. Briefly,...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "The contact-mediated response of peripheral-blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis" ppt
... section). The results in Fig. 4a indicate that the inhibitory effect of RA sera is evident only in patients with active disease. To explore the disease specificity of this inhibitory activity ... Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphati- dylinositol 3-kinase and nuclear factor κB pathways...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia" pdf
... phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia Adetola B Adesida, Lisa M Grady, Wasim S Khan and Timothy ... times of P1 and P2 human meniscus cells were obtained by plating P1 and P2 meniscus cells at 5 ì 10 5 cells in 75 cm 2 tissue cul...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "The second chance story of HIV-1 DNA: Unintegrated? " pps
... accessibility to expression in nondividing BioMed Central Page 1 of 5 (page number not for citation purposes) Retrovirology Open Access Commentary The second chance story of HIV-1 DNA: Unintegrated? ... sensi- tivity of fluorescent reporters dictates that a large number of molecules must accumulate in order to be detectable by flow cytometry. This may lead to underestimat...
Ngày tải lên: 13/08/2014, 05:21