Báo cáo y học: " Reconstitution of the myeloid and lymphoid compartments after the transplantation of autologous and genetically modified CD34+ bone marrow cells, following gamma irradiation in cynomolgus macaques" potx

... orthologue in these Recovery of bone marrow clonogenic activityFigure 5 Recovery of bone marrow clonogenic activity. Bone marrow- derived colony-forming units following sublethal irradiation of cynomolgus ... possibly due to a delay in the integration of the transgene during differentiation, resulting in the formation of clusters of GFP-positive cells...

Ngày tải lên: 13/08/2014, 05:21

... during the reconstitution and the quality of subunits a, b, and c obtained during purification. In summary, these results establish the conditions for the synthesis and the purification of individual ... m M K 2 SO 4 and the radioactivity was determined by c-counting. Determination of ATPase activity ATP hydrolysing activity was determined spectrophoto- metrically...

Ngày tải lên: 31/03/2014, 15:20

... roles in the pathogenesis of autoimmune diseases. Consequently, therapeutic targeting of B cells is gaining prominence in our clinical armamentarium for an ever expanding array of autoimmune and ... of central importance and is the focus of the article by Rouzière and coworkers [1]. Indeed, the breakdown of B cell tolerance for autoantigens may be at the core...

Ngày tải lên: 09/08/2014, 07:20

... behavior across the day in contrast to endpoint where the majority reported consistency in behavior. Further, at study end- point the majority of caregivers reported that handling changes in their child's ... social interactions since beginning the study medication, and 91.9% were satisfied with the efficacy of the study medi- cation on their child's attentio...

Ngày tải lên: 25/10/2012, 10:06

... history can be obtained by asking the indi- vidual “how many times do you laugh during your regular day?” and have the individual rate their level on a scale of one to ten. Furthermore, other ... hepatobiliary system, genitourinary system, reproductive system, CNS and psychiatric conditions, and then to specify the name of that con- dition. If the participant failed to i...

Ngày tải lên: 26/10/2012, 09:57

... domains or by specific phosphopeptides that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the ... diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the risk fo...

Ngày tải lên: 31/10/2012, 15:37

... formation of 16a-hydroxyprogesterone. Both expressed enzymes had no lyase activity towards PROG or 17-OHPROG. Understanding of the complexity of hydroxylase and lyase activity of CYP17 by way of primary ... cytochromes P450 has identified domains in the primary sequence of human CYP17 which are involved in the catalytic activity of the enzyme, i.e. substrate docking...

Ngày tải lên: 08/03/2014, 09:20

... protein quality between Pfg27 A and the rest of the constructs was retained. Therefore, the differing protein solubilities were inherent in the constructs and could not be modulated by varying the ... proteins were expressed and purified. Our results show that the fusion proteins were labile and only partially soluble in five of the constructs resulting in very p...

Ngày tải lên: 23/03/2014, 21:20

... groups. The contact area of the distamycin amidinium end was investigated by evaluating the hydrogen positions and interaction energy terms for the interactions between the terminal drug segment and ... of the amide linkers between the pyrrole rings form bifurcated hydrogen bonds with the thymine or adenine bases. The central N5(D) atom of the drug is hydrogen-bo...

Ngày tải lên: 24/03/2014, 04:21

... with Ca 2+ calmodulin, they should also inhibit the activity of calcineurin. The four model peptides lesueurin, citropin 1.1, frenatin 3 and caerin 1. 9, all inhibit the activity of calcineu- rin, but at ... the presence of increasing concentrations of Ca 2+ calmodulin, the inhibition dropped by  50% in each case. In addition, these peptides also inhibit the activit...

Ngày tải lên: 31/03/2014, 15:20