... withCa2+calmodulin, they should also inhibit the activity of calcineurin. The four model peptides lesueurin, citropin 1.1,frenatin 3 and caerin 1. 9, all inhibit the activity of calcineu-rin, but at ... the presence of increasing concentrations of Ca2+calmodulin, the inhibition dropped by 50% in each case. In addition,these peptides also inhibit the activity of calcineurin, anotherenzyme that ... partly because they s howstructural similarity to the human brain endomorphins (e.g.YPWG-NH2) [23]. The sequences of two tryptophyllins areas follows: tryptophyllin L1, FPWL-NH2; tryptophyllinL2,...