... J, Brady JN: Stabili-zation of wild-type p53 in human T-lymphocytes trans-formed by HTLV-I. Oncogene 1993, 8:3029-3036.34. Ariumi Y, Kaida A, Lin JY, Hirota M, Masui O, Yamaoka S, Taya Y, Shi-motohno ... 272–303 of the CDK4 protein directly inter-act with Tax. Alternatively, the deletion of these regionsmay reduce the protein& apos;s affinity to Tax by affecting itsconformation.Relevance of the ... activity inthe presence of Tax may be explained by intensified asso-ciation of CDK4 and its positive cyclin regulatory subunitand by resistance of the complex to inhibition by p21CIP1[36,37].To...