Báo cáo y học: " The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus" pdf
Báo cáo y học: " The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus" pdf
... Dur-ing assembly, the MA domain, through its myristylatedmoiety and its highly basic domain, anchors assembly complexes to membranes [4-6]. Whether assembly takesplace at the inner leaflet of the ... whether Stau1 interacts first with NC or with the genomic RNA to recruit the other partneror independently interacts with each of them through dif-ferent pathways during HIV-1 assembly and ... protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminusLaurent Chatel-Chaix1,2, Karine Boulay1, Andrew J Mouland2,3,4 and Luc DesGroseillers*1Address:...
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Báo cáo y học: " Identification of NCAM that interacts with the PHE-CoV spike protein" pdf
... to screen the clones that display the adhesion protein, the c DNA library from N2a cells was panned with the S protein. The 96-well plates were coated with 200 μl of the purified S protein (2 ... sequencealignment. YL participated in the design of the NCAM siRNAs. KCparticipated in the design of the study. FG and DS conceived of the study and participated in its design and coordination. ... [34].Finally, identification of the NCAM that interacts with PHE-CoV spike protein will facilitate the description of the binding domai n of the spike protein, which will pre-sumably be the most...
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Báo cáo y học: "Virus-host interactions: new insights from the small RNA world" pot
... [9]. The tomato bushy stuntvirus (TBSV) protein p19 binds both siRNA and miRNAduplexes and thus presumably inhibits the assembly of the RISC effector complex [10]. The vaccinia virus protein ... antigen increased the recognition of SV40-infected cells by antigen-specific cytotoxic T cells [16]. The viral miRNA may thus reduce the susceptibility of the virusto the host immune system.Viral ... recently been shown to sup-press RNA-silencing pathways. The protein HC-Pro, encodedby the tobacco etch potyvirus, was the first viral protein iden-tified as suppressing RNA silencing, but the...
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Báo cáo y học: "External iliac artery thrombosis associated with the ilio-inguinal approach in the management of acetabular fractures: a case report." doc
... carried out the duplex-sonography and participated in the radiologic diagnosis. MT. GH partici-pated in the design of the study and performed the coor-dination and helped to draft the manuscript. ... interests The authors declare that they have no competing interests.No financial support from any company was received in the performance of this study, nor do any authors haveequity or other financial ... al. [1]In the present case, the injury resulted from a fall on the hip. The patient was operated on five days after the trau-matic event, without any traction having been applied in the interim....
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Báo cáo y học: " Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch" pps
... heavilyon functions provided by their host cells, and haveevolved diverse strategies to exploi t the biology and bio-chemistry of hosts for their benefit [1]. The ubiquitinsystem is one of the ... degradedby the lysosome pathway and in part by the proteasomepathway in HSV-2-infected cells. The decrease of Itch inVero-GFP-UL56 cells was also blocked by CQ and par-tially by MG132 (Fig. 3C). Therefore, ... originallyinduced Itch to degrade via primarily the lysosome and partially the proteasome pathways. From the view pointof the degradation of ubiquitinated proteins, this resultconcurs with the...
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Báo cáo y học: "Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin: an open-label dose escalation study" pps
... (measured at entry)achieved during DSG treatment,no further increase of >25% in the maximum urinary protein excretion within the previoustwo cyclesWithin the previous two cycles, afurther increase ... treatmentadditional urinary protein excretion1decreased by < 25%during DSG treatment; no furtherincrease of >25% in the maximum urinary protein excretion within the previoustwo cyclesWithin the previous ... 12B-lymphocyte, T-lymphocyte and macrophage/monocytefunction. In rodents and human cell systems, DSGshows a dose-dependent inhibition of primary and sec-ondary responses to T-, B- and antigen-presenting...
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Báo cáo y học: "Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study)" pps
... not included in the study,creating a bias against the treatment. On the other handsome patients could be compliant with the bundle justbecause their severity was low and they did not need flu-ids ... should really be to complete the wholebundle gaining the synergy of the bundle elements per-formed in unison rather than each one independently.Only 12% of our patients fully completed the core ... published. The present analysis wasperformed to describe compliance with the SSC six-hourbundle and its impact in severe sepsis mortality.Materials and methodsStudy design The SACiUCI study was...
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Tài liệu Báo cáo khoa học: Mouse recombinant protein C variants with enhanced membrane affinity and hyper-anticoagulant activity in mouse plasma pptx
... complex assembly and enzyme catalysis in vivo.Membrane affinity of a Gla protein often correlates with its membrane localized activity. Strategies used toincrease the affinity of the Gla protein membraneinteraction ... Ca2+turns the N-terminal part of the Gladomain inside out, exposing the hydrophobic x-loopto solvent and burying the majority of the Gla resi-dues. Of the seven Ca2+, the majority are buried and are ... sepsis, the APC system malfunctions atalmost all levels. First, plasma levels of the zymogen protein C are low or very low because of impaired syn-thesis, consumption and degradation by proteolyticenzymes...
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Báo cáo y học: "arly relief of osteoarthritis symptoms with a natural mineral supplement a herbomineral combination: A randomized controlled trial" pdf
... ster-oids, or other agents that may affect the outcomes of the study other than the rescue medication. Any medicationtaken by subjects for two months prior to the inclusion of the study, and whose ... mg/dayCopper 0.074 mg/day 0.11 mg/dayIron 119 mg/day 178 mg/dayLead 0.013 mg/day 0.020 mg/dayLithium 0.02 mg/day 0.03 mg/dayMagnesium 11 mg/day 17 mg/dayManganese 0.29 mg/day 0.44 mg/dayMercury ... mg/dayMercury 0.0012 mg/day 0.0017 mg/dayMolybdenum 0.002 mg/day 0.003 mg/dayNickel 0.027 mg/day 0.040 mg/dayPhosphorous 3.8 mg/day 5.7 mg/dayPotassium 20 mg/day 30 mg/daySelenium 0.0030 mg/day 0.0045...
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Báo cáo y học: "Cerebral involvement in a patient with Goodpasture''''s disease due to shortened induction therapy: a case report" pdf
... disease, a type II hypersensitivity reac-tion is present with antibody and T-lymphocyte reactivityto the NC1 domain of the alpha3 chain of type 4 collagen[1]. These specific antigens exist on the ... pathogenic antibodies with plasmapher-esis, as the activity of the disease correlates with the anti-body level. The latter has drastically improved the prognosis and outcome in patients with Goodpasture'sdisease ... anti-GBM antibodies in the plasma. A cyclophosphamide pulse therapy was adminis-tered, but renal disease progressed and hemodialysisbecame necessary and the cyclophosphamide therapy wasterminated....
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