... blood-stream could be involved in the lung- to-brain interac-tion during mechanical ventilation. • Lung- brain cross-talking is an emerging area ofresearch in critically ill patients receiving mechanical ventilation. AbbreviationsALI: ... C: The Rat Brain in Stereotaxic Coordinates. 6 edition.Academic Press: San Diego, California, USA; 2007.15. Akazawa KH, Cui Y, Tanaka M, Kataoka Y, Yoneda Y, Watanabe Y: Mappingof regional ... v1.40g (Wayne Rasband, NIH, USA). Lung damage was determined using a Lung InjuryScore ( LIS), based on the evaluation of alveolar edema,hemorrahage, neutrophil infiltration and alveolar septalthickening...