Báo cáo khoa học: "Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use" pptx

... hyperglycemia, the degree of which is directly related to their specific β-receptor activity [18]. Given the hyperglycemia-related aggravation of oxidative stress, phosphodiesterase III inhibitors might prove ... control groups. The mechanism of this putative renal protective property of milrinone remains unsettled in the present study. One might speculate that phosphodiester...

Ngày tải lên: 13/08/2014, 03:21

... these effects are indirect, with TSA leading to the induction of a factor (or factors) involved in the repression of a downstream target; alternatively, a direct effect on either the acetylation of ... a transcription factor, or recruitment of repressive factors to acetyl–histones via bromodomain interactions could be envisaged. In support of the latter notion the down- B A C...

Ngày tải lên: 16/03/2014, 18:20

... effect of Laccaria laccata - even observed in seedlings with a low percentage of mycor- rhizal roots - to be related to the capacity of this fungus to produce growth regulators such ... relation to rate of CO 2 assimi- lation. I. Influence of nitrogen nutrition, phos- phorus nutrition, photon flux density and am- bient partial pressure...

Ngày tải lên: 09/08/2014, 03:25

... with no histor y of radiotherapy pre- sented with gradual swelling of the neck and dyspnea of 7 to 8 months duration. Magnetic resonance imaging (MRI) and computed tomography (CT) scans of the neck ... management of mediastinal liposarcoma extending from hypopharynx to carina: Case report Thomas L Gethin-Jones, Nathaniel R Evans III, Christopher R Morse * Abstract We describe t...

Ngày tải lên: 09/08/2014, 03:21

... Contribution of individual modules of oxidative phosphorylation to the overall response of system variables to palmitoyl-CoA. The partial integrated responses (IR) of each module to 5 l M palmitoyl-CoA ... effects relate to one or many primary effects. To acknowledge this, using modular kinetic analysis, we established that the pri- mary cause of the effects of palm...

Ngày tải lên: 19/02/2014, 05:20

... case of TIMs from Plasmodium and yeast. Interestingly, the thioether group of M103 is positioned to make a potentially stabilizing contact with the guanidinium group of R99 (equivalent to R98 of ... and yeast TIM). The shortest distance from the sulfur atom of M103 to the NH1 nitrogen of the guanidium group of R99 is 3.23 A ˚ , suggestive of a potentially stabilizing S-H...

Ngày tải lên: 18/02/2014, 11:20

... comparable to those of H4-(86–100), HNr and compound 3 (Fig. 5). Their lower potencies in this assay may be due to their lower ability to diffuse out of the paper disk and come into contact with ... absence or presence of vari- ous concentrations (from 0.5 to 300 lgÆmL )1 ) of HN and related compounds in a total volume of 50 lL. In some experiments, the inhibitory effec...

Ngày tải lên: 18/02/2014, 14:20

... versions of these two isoforms, as well as of the Mxi1-WR isoform that lacks the SID, and shown to give rise to proteins of the expected size expressed at similar levels (Fig. 1A). Each of these ... [27], to induce the pro-apoptotic mitochondrial membrane permeabilization that is essential for apoptosis [28] or to prevent down-regulation of colony-stimulating factor-1 protei...

Ngày tải lên: 18/02/2014, 16:20

... to bind to the membrane of cells. Inhibitory effects of VVA1 on the hemolytic and cytotoxic activity of VVA2 The effects of VVA1 on the hemolytic activity of VVA2 were studied by incubation of ... the cytotoxicity of volvatoxin A2. Volvatoxin A1 by itself was found to be nontoxic, and furthermore, it inhibited the hemolytic and cytotoxic activit- ies of volvatoxin A2...

Ngày tải lên: 19/02/2014, 06:20

... the dimerization of EF-Ts in the crystal. In the crystal of E. coli EF-Tu–EF-Ts, a quaternary complex, formed by two molecules of each of the elongation factors, is observed. The coiled-coil motifs of each of ... is 78% of the point of growth inhibition of UY211 (D 420 ¼ 0.60). The point of growth inhibition of GRd.tsf when expressed as a percentage of that of UY211,...

Ngày tải lên: 21/02/2014, 00:20