Báo cáo khoa học: "Could pharmacogenetic data explain part of the interindividual sensitivity to methadone-induced respiratory depressio" pps

... differen- tial binding of methadone to its variants [9], it is presently not possible to determine whether and to what extent this could influence sensitivity to respiratory depression. At the pharmacodynamic ... extrapolating the data from these single-dose studies to cases of overdose in tolerant patients. However, the 118A>G polymorphism in the human µ-opioid...

Ngày tải lên: 13/08/2014, 03:20

... recognition of all the data generators contributes to best practices. 4. Security Trust and the promotion of data sharing rely on data management and security mechanisms and also on oversight of their ... funders of health research [6]): ‘Equitable: any approach to the sharing of data should recognize and balance the needs of researchers who generate and use d...

Ngày tải lên: 11/08/2014, 12:21

... interruption of the geometry of the recognition helix for either Antp or the TTF-1 HD, the anomalous amide exchange pattern and the NOE connectivity data of the C-terminal portion of helix III had to be ... relax- ation data, the generalized order parameter reflects the amplitude of the internal motion of the 15 N– 1 H vectors in the fast ps -to- ns time...

Ngày tải lên: 18/02/2014, 16:20

... analyses of the predicted amino acid sequence showed that the C-terminal half of the RepA of the pIT3 plasmid is sequence-similar to the helicases of the phage-encoded superfamily III pro- teins. The ... in pGEMTeasy vector (Promega, Milan, Italy). The nucleotide sequences of both DNA strands of the inserts were verified. The NdeI–XhoI fragments were cloned in...

Ngày tải lên: 18/02/2014, 18:20

... because of the relative lack of protection of the catalytic domain and the junction nucleotides that link it to the other major domain. We attempted to probe the InDG b RNA with Fe 2+ -EDTA in the ... 23S.5DG b pre-RNA, and the binding of a minimum of n Mg 2+ ions leads to formation of the active complex, whereas binding of a minimum of m Mn 2+ ions forms...

Ngày tải lên: 19/02/2014, 07:20

... the origin of the kingdom Plantae among the phyla of the ancestral kingdom Protozo a [45]. Hence, it is reasonable to suppose a common origin of extant APXs in the ancient line of protists. The ... though the C-domains of the catalase–peroxid- ases had lost the ability to bind the prosthetic heme group, the structural elements remained conserved. In additio...

Ngày tải lên: 19/02/2014, 16:20

... [10]. The Cys residue was added to the C-terminal end of the 13-amino-acid peptide corresponding to the primary sequence of the Tat protein to provide a sulfhydryl group for further ligation to ... Thus, steric hindrance of the heterologous protein itself could reduce the exposure of these shorter peptides to cellular structures, and therefore, reduce the ef®...

Ngày tải lên: 21/02/2014, 03:20

... U.S. Department of Education, through Grant R305A080157. The opinions expressed are those of the authors and do not necessarily represent the views of the Institute or the U.S. Department of ... evaluated. If the model assigns only one of the words a probability, prefer it, based on the assumption that the unknown probability of the other word is lower. If...

Ngày tải lên: 22/02/2014, 03:20

... Mutations in the tip of the minidomain were found to affect the stop codon specificity of the factor. The results provide new insights into the possible role of the C-domain in the process of translation ... supported by the existence of strong cros- speaks between the signal of the HN of Gly337 in the open conformer and the signal of the water pro...

Ngày tải lên: 06/03/2014, 11:20

... of Cyn d 24. (A) Nucleotide and deduced amino acid sequences of Cyn d 24. The numbers on the right of the figure indicate the positions of the nucleotide sequence. The numbers on the left of the ... reac- tions, rather than imperfect biosynthesis [13]. Of the plant allergens listed in the of cial allergen database of the IUIS, about 25% belong to various...

Ngày tải lên: 07/03/2014, 12:20