Báo cáo khoa học: "Bench-to-bedside review: Distal airways in acute respiratory distress syndrome " doc

... was present only in one patient (no. 13). Clinical data are given in Table 1. Twenty healthy non- smoking students independent of the investigating institutions were enrolled and interviewed to ... ventilation by a moderate increase in PEEP. Accordingly, increasing PEEP from 0 to 15 cmH 2 O has been shown in a study of pulmonary mechanics to increase pulmonary compliance in some pat...

Ngày tải lên: 12/08/2014, 22:21

... experimental and clinical findings for the role of distal airways in acute respiratory distress syndrome (ARDS) as well as evaluating their function in mechanically ventilated patients. Distal airways: ... not observe inflammatory cell infiltration into the airways or increased proinflammatory cytokines in alveolar fluid. They interpreted this to indicate the earliest...

Ngày tải lên: 13/08/2014, 03:20

... of cytokines during mechanical ventilation of acutely injured lungs is alteration in alveolar mechanics (i.e. the dynamic change in alveolar size and shape during ventilation) – alveolar instability ... alveolar instability was associated with modest increases in interleukin-6 levels after 4 hours of mechanical ventilation, even in the absence of neutrophil infiltration, and that this...

Ngày tải lên: 12/08/2014, 20:20

... written, informed consent was obtained. After intubation with a cuffed tube, all patients received into the trachea 20 ml of normal saline containing 7.5 mg of 13 C-dipalmitoyl- phosphatidylcholine ... number not for citation purposes) Respiratory Research Open Access Research Surfactant disaturated-phosphatidylcholine kinetics in acute respiratory distress syndrome by stable iso...

Ngày tải lên: 12/08/2014, 15:20

... [11,12], adequate replacement of intravascular fluid volumes is required to maintain cardiac Commentary Positive end-expiratory pressure in acute respiratory distress syndrome – an old yet mysterious ... end-expiratory pressure (PEEP) into the practice of mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) [1] was among the most important mil...

Ngày tải lên: 12/08/2014, 20:20

... essentially results from tidal opening and closing of distal lung units (shear–stress). High PEEP appears ‘protective’ against VILI. In oleic-acid-induced and endotoxin-induced lung injuries, distal lung units ... resulting inflammatory reaction [6]. Following these studies, the concept that VILI and pulmonary biotrauma are caused by cyclic opening and closing of distal lung units bec...

Ngày tải lên: 13/08/2014, 10:20

... for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000, 342:1301-1308. 5. Stenqvist O, Odenstedt H, Lundin S: Dynamic respiratory mechanics in acute lung injury /acute ... conventional two- point analysis [37-39]. Therefore, we excluded data corre- sponding to that time interval from the fitting and included, instead, the loading interval during v...

Ngày tải lên: 13/08/2014, 20:21

... most severe clinical scenario evolves in multiple organ failure and death [1]. Sepsis is defined by the presence of an infective agent in combination with typical clinical and laboratory findings of infection ... other cytokines and independent from mechanical loading in endotoxemia, has recently been described in rats [104]. In fact, increased plasma levels of endotoxin have also b...

Ngày tải lên: 12/08/2014, 20:20

... lengthened by using higher inspiratory flow settings (70–100 l/min) during volume cycled ventilation, using a shorter inspiratory time fraction, reducing respiratory rate, and eliminating any inspiratory ... gas- trapping by splinting the airways open [29]. In terms of reducing the work of breathing, the addition of extrinsic PEEP in patients with dynamic hyperinflation would theoreti...

Ngày tải lên: 12/08/2014, 22:22

... the number of domains. Each set contained all proteins with a fixed number of domains, for example ‘set6’ contained pro- teins with six domains. Each protein from a given set containing proteins of length ... N domains was compared with each protein from the set containing proteins of length N)1 domains. For example, a protein with six domains was compared with all proteins that have five domai...

Ngày tải lên: 19/02/2014, 07:20