Báo cáo khoa học: "Echocardiography and assessing fluid responsiveness: acoustic quantification again into the picture" pptx

... to assess fluid responsiveness. First, despite the careful implementation of passive leg raising, a small shift or displacement of the TOE probes in relation to the LV short axis could distort the ... at the bedside. Competing interests The author(s) declare that they have no competing interests. Acknowledgements Work conducted by the authors is supported by an unrestricted gr...

Ngày tải lên: 13/08/2014, 03:20

... whether these messages are translatable. In the second step, we characterized their coupling to different signaling pathways and their modu- latory role on the CRFR1a activity. Materials and ... expression To verify that the constructs produce proteins of the expected masses, we attached the V5 epitope to the C terminus of the CRFR1 isoforms (Fig. 1C). The predicted masses...

Ngày tải lên: 07/03/2014, 15:20

... index to evaluate the heart size in the horse and that it should not be considered as a tool for assessing potential performance. On the other hand, there are currently more suitable and accurate ... at least in the final part of the PQ interval and/ or in the initial part of the ST interval, the ventricular depolarization could start and continue with currents that c...

Ngày tải lên: 07/08/2014, 18:20

... FAD and FMN. The two domains are separated by a CaM-binding motif. During catalysis, NADPH- derived electrons transfer into the FAD and FMN in each NOS subunit and then on to the ferric heme in the ... to reduce the heme (Fig. 5). However, the lowest possible rates for the FMN subdomain dissociation step (k off ) in the CaM-bound eNOS and nNOS are  1 and 20 s )1 ,...

Ngày tải lên: 18/02/2014, 11:20

... juxtapose itself against and interact with the membrane, thus enabling the SHBG domain to bind to the receptor on either the same or another cell. Axl, Sky and Mer in cancer The transforming activity ... binding to and activa- tion of the receptor tyrosine kinases Axl, Sky and Mer. Furthermore, a hallmark of the Gas6–Axl system is the unique ability of Gas6 and pro-...

Ngày tải lên: 19/02/2014, 05:20

... two other state-of- the- art systems, the Stanford tagger (Toutanova et al., 2003) and the SVMTool (Gim ´ enez and M ` arquez, 2004). Both systems are trained with the same train- ing data and ... domain and the other is optimized for a domain specific to the training data. During decoding, we dynamically se- lect one of the models by measuring similarities be- tween input...

Ngày tải lên: 19/02/2014, 19:20

... derived from the maximum velocity (V), divided by the molar concentration of the enzyme (e 0 , included in V max ). R and T are the gas constant and the temperature (in Kelvin), respectively. The values ... mapping On the basis of the assumptions of Hiromi [30] that the intrinsic rate of hydrolysis (k int ) in the productive complex is independent of the length of t...

Ngày tải lên: 20/02/2014, 03:20

... showing the location of amyloidogenic mutations and position of b-strands. (A) The struc- ture of the polypeptide backbone of the two chains (purple and blue) is shown along with the location of the ... occurs in the region between residues 45 and 58. This region contains the C strand, CD loop, and D strand which are located at the edge of each monomer [97]. It has b...

Ngày tải lên: 07/03/2014, 10:20

... b-strand 7, with mutations R110G and F112R directly in the dimer–dimer interface. As a result of the spatial dis- position of monomers and their b-strand elements in the a-crystallin domain, the ... study are not located in either of these strands and they are not con- sidered further. As the basic p26 oligomer building block, dimers interact to form tetramers, the next leve...

Ngày tải lên: 07/03/2014, 12:20

... and ARA440 (Table 1) were used and introduced unique NdeI and XhoI restriction sites at the 5¢ and 3¢ end, respectively, and the resulting PCR product was inserted into pET30a digested with the ... 0.4 and 52.2 ± 0.5 min, respectively), indicating both the stability of the strain bearing the in-frame deletion and the fact that the AraL enzyme is not involved in...

Ngày tải lên: 14/03/2014, 23:20