Báo cáo khoa học: "Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat" ppsx

... [4,6,8,9]. There is an increasing body of evidence that activated protein C (APC) exerts beneficial effects in the microcirculation. Human plasma-derived and human cell-produced recombinant protein C inhibits ... biologic activities of APC, besides the inhi- bition on coagulation, which may affect the microcirculation. Important actions of APC are also the profibrinolytic...

Ngày tải lên: 13/08/2014, 03:20

... expression and pro-inflammatory cytokines via the induction of protease activated receptor-1. Inadequate bind- ing of aPC to EPCR could explain the absence of the anti- inflammatory effect and be responsible ... coli infusion in the baboon. J Clin Invest 1987, 79:918-925. 23. Roback MG, Stack AM, Thompson C, Brugnara C, Schwartz HP, Saladino RA: Activated protein C concentrate...

Ngày tải lên: 12/08/2014, 23:22

... and indi- viduals with protein C deficiency suggesting that the circu- lating protein C concentration is the limiting factor in the rate of activation of protein C [33]. Therefore, protein C levels ... a critical step in the host defence against sepsis since inhibition of protein C binding to EPCR (in baboon model) is shown to con- vert the response to suble...

Ngày tải lên: 10/08/2014, 22:20

Ngày tải lên: 13/08/2014, 01:20

... against [9,10], and as such, the results of this study are of interest. The need for assessment of clinical and economic outcomes after the introduction of a novel therapeutic agent is increasingly ... appears there is a role for generation of new clinical evidence. Costs in their study were collected using microcosting methods, which are regarded as the most valid means of measurin...

Ngày tải lên: 13/08/2014, 08:20

... from Charles River (Maastricht, the Netherlands) and maintained in the ani- mal facility of the Academic Medical Center (University of Amsterdam) according to national guidelines with free access ... Blick KE: Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest 1987, 79:918-925. 29. Bajzar L, Nesheim ME, Tracy PB...

Ngày tải lên: 13/08/2014, 20:21

... of activated protein C dosing will provide the data to determine the possible use of activated protein C as a therapy in human H1N1 infection. © 2010 BioMed Central Ltd Activated protein C for ... brinolysis inhibitor. Activated throm bin activatable fi brinolysis inhibitor inhibits the chemotactic factors C3 a and C5 a, which could be important for prevention of in u...

Ngày tải lên: 13/08/2014, 20:22

... In the present issue of Critical Care, Pettila and colleagues report the fi rst single-centred pilot randomized controlled trial of activated protein C (APC) in alcohol- induced acute pancreatitis ... erence in bleeding complications, yet serious bleeding is actually a relatively infrequent event in patients treated with APC. In a meta-analysis of 10,679 APC-treated pati...

Ngày tải lên: 13/08/2014, 21:21

... analyzing the data and interpreting the results, revising the manuscript, and approving the manuscript in its final form. Competing interests The authors declare that they have no competing interests. Received: ... Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine, et al: Survi...

Ngày tải lên: 14/08/2014, 07:21

... role in PEDV attachment and entry in the muscle cells of experimental animals. Thus, the increased entry of PEDV into the muscle cells might induce higher antibody production against PEDV when compared ... presenting cells in experimental animals. In addition, as molecular mechanisms of dendritic cell-induced T cell activation, pAPN appeared to be involved in activation of...

Ngày tải lên: 07/08/2014, 18:20