Báo cáo khoa học: "Heterotopic ossification of the knee joint in intensive care unit patients: early diagnosis with magnetic resonance imaging" docx

... examine the potential therapeutic and quality of life benefit associated with an early diagnosis of HO.Conclusion The early MRI findings of HO in the knee joint are interstitialedema of the ... 8.2Heterotopic ossification (HO) in the knee joint of 11 intensive care unit patients. Increase of serum levels of alkaline phosphatase (ALP) was the earliest indication of HO. MRI, magnetic resonance ... resonance imaging (MRI) findings onclinical suspicion of HO in the knee joint of patients hospitalised in the intensive care unit (ICU).Methods This was a case series of 11 patients requiringprolonged...

Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx

... chymotrypsin numbering) is involved in the formation of a salt bridge with the N-terminal Ile of the mature enzyme for completing the formation of Fig. 2. Distribution of charged amino acids in Panulirus ... different in comparison with those of vertebrate trypsins, and also they are important forinhibitor binding [8]. The phenylalanine and Ile resi-dues in crayﬁsh Loop37 interact with the C-terminalsegment ... at the junction of the two barrels.Another conserved characteristic of lobster trypsinsis the presence of calcium-binding sites (Fig. 3C). The calcium-binding motif does not occur in manyinvertebrate...

Báo cáo y học: "Synovial hemangioma of the knee joint in a 12-year-old boy: a case report" pptx

... effusions without a history of trauma. If there are no intermittent effusions, the diagnosis will be even more difficult. In cases of nonspecific symptoms and longstanding knee pain the diagnosis of ... mass on the medial aspect of his left knee. In fullflexion the mass appeared more pronounced. He deniedany history of trauma and there was no effusion in his knee, with the joint not showing any ... signs of phlebolithsbut the MRI scan showed a well-defined mass locatedwithin the suprapatellar pouch, but infiltrating the vastusmedialis muscle. The mass appeared lobulated in contour with internal...

Báo cáo khoa học: Enzymatic features of the glucose metabolism in tumor cells ppt

... [115] reported the ﬁnding of two potential binding sites for HIF-1 in the ﬁrst intron of the PK-M gene. On the other hand, Yamada andNoguchi [116] reported that there is no HIF-1 bindingsequence ... synthetase (PRPPS)(EC 2.7.6.1) The formation of phosphoribosyl pyrophosphate byPRPPS represents the ﬁrst step in the de novo synthesis of purines, pyrimidines and pyridines. The activity of PRPPS ... be induced by incubating cancer cells with oligomycin, an inhibitor of mitochondrial ATPsynthetase [159,160]. Similarly, reduction of OXPHOSby targeted disruption of frataxin, a protein involvedin...

Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf

... role of the lastamino acids in the C-terminus of MaL. Deletion of the four last amino acids strongly reduced the expression of the protein in T. reesei and S. cerevisiae. Further-more, the deletion ... preventing binding of oxygen.We analyzed the azide inhibition and determined the inhibition constants for sodium azide, in order to see the effect of the mutation (L559A) on the bindingproperties ... (Fig. 5B).Owing to the lower steric limitations of the side chain of the Ala than of the Leu, water may occupy the space. Furthermore, the side chain of His140, which iscoordinated to the T3 copper,...

Báo cáo khoa học: Mutational analysis of the C-domain in nonribosomal peptide synthesis pot

... bound in the binding poc ket o f a nother e nzymemolecule within the active homomultimer. This could explain the distance in sequence homology with NRPSs C-domains displayed in the alignment of the ... Nevertheless, the datapresented in this s tudy excludes the idea of a c atalytictriad involved in C-domain catalysis of NRPSs. With the ®nding of the additional residue R62 and con®rming the residues ... to A in the His-motif(italic) of the corresponding Asp domain of the surfactinsynthetase was found to abolish surfactin production in the B. subtilis producer strain [21]. Accordingly, the pres-ence...

Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation pot

... extreme modulations of enzyme activities. In particular, in the combinations involving the decrease of glyoxalase II activity the effect is equival-ent to the modulation of the other parameters ... quantitativeanalysis of the most critical parameters of the pathwayregarding this goal requires the knowledge of the intra-cellular concentrations of all metabolites involved anda kinetic model that ... GSH in the glyoxalase pathway in L. infantum,as occurs in other enzymatic systems in trypanosom-atids. Substrate dependence of the glyoxalase enzymeswas then evaluated in this parasite by initial...

Báo cáo khoa học: Functional role of the linker region in puriﬁed human P-glycoprotein pot

... (subunit A) is shown in light pink and the other (subunit B) isshown in gray. (A) Side view of the diagrams. The C-terminal a-helix of subunitA is shown in red and the N-terminal elbowhelix of ... restores the inward-facing state. The linker region of P-gp can be assumedto connect the C-terminal helix of subunit A (shown in red in Fig. 7) with the N-terminal elbow helix of sub- unit B ... elbowhelix of subunit B is shown in purple. The putative linker region of P-gp is shown as adotted line and the start of the linker regionis denoted with an asterisk. The minimumpath of the linker region...

Báo cáo khoa học: " Immunohistochemical Study of the Endocrine Cells in the Pancreas of the Carp, Cyprinus carpio (Cyprinidae)" docx

... demonstrated in the mantle regions (a, b). In the pancreaticduct, they were located in the inter-epithelial cells or basal regions of epithelial lining (df). In addition, insulin-IR cells werealso ... Lee in the basal regions of the pancreatic duct epithelial lining. In addition, glucagon-IR cells were also located in the cellclusters situated in the lamina propria regions in the case of large ... 5d) in there, the cytoplasmic process of insulin-, glucagon- andsomatostatin-IR cells were intermingled with each other. In the secondary islet regions, hPP-IR cells were mainly located in the...

Báo cáo khoa học: "Ultrasonographic examination of the carpal canal in dogs" doc

... tendon [10,11]. Our findings were in line with the preceding reports for the flexor tendons within the carpal canal. Ultrasonographic identification of the nerves in both the sagital and transverse ... reliably interpreting the US images. In the transverse plane, the normal tendons in dogs have medium echogenity with hyperechoic pinpoints that represent the collagen fibers within the tendon ... prolongation of the sensory nerve action potential of the median nerve was determined at the hyperflexion position of the carpal joint in dogs [20]. The computed tomographic morphometry of the canal...

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