... been demonstrated in clinical studies[15,25], an in vitro study demonstrated a 10- to 16-foldincrease in the minimal inhibitory concentration of the minocy-cline–rifampin combination with respect ... for infection, includingvancomycin–heparin and vancomycin–ciprofloxacin–heparinsolutions [42,44]. Because the use of vancomycin is an inde-pendent risk factor for the acquisition of vancomycin-resistantenterococci ... already been proven tobe effective in clinical trials in preventing CVC infections, par-ticularly those intended for short-term use, should be consid-ered in clinical practice. Moreover, many...