... pathway and Wnt/β-catenin signaling, LIPUSmay activate β-catenin signaling via the PI3K/Akt pathway. Asindicated in Figure 4c,d, the nuclear localization of β-catenin,as a marker of the β-catenin ... collagen sponge. In addition, the anabolic LIPUS signal transduction to the nucleus via the integrin /phosphatidylinositol 3- OH kinase/Akt pathway ratherthan the integrin/MAPK pathway was generally ... Yokohama City, Kanagawa 236 -0004, Japan4Department of Functional Biology, Kanagawa Dental College, 82 Inaokachyo, Yokosuka City, Kanagawa 238 -8580, Japan5Department of Environment and Information...