Báo cáo khoa học: "Bench-to-bedside review: The role of glycosaminoglycans in respiratory disease" potx

... LP and SES constructed and refined the search strategy. SES and LP acquired the data. Analysis and interpretation of the data was completed by LP, KM, and SES. Drafting of the manuscript and ... understand the overallstate of research activity in the area of the use of sys-tematic reviews in healthcare decision making. Scopingreviewsareoftenundertakenwhenanareahaslittlepublished research ... technical assistance.Canadian Institutes of Health Research and each author’s institution. SES issupported by a Tier 1 Canada Research Chair. JNL is supported by a Tier 2Canada Research Chair. The...

... overdistension, recruitment maneuvers, and bacterial translocation.Review Clinical review: The implications of experimental and clinical studies of recruitment maneuvers in acute lung injuryEnrique ... reviews the intrinsic mechanisms of mechanical stress, the controversy regarding clinical use of recruitment maneuvers, and the interactions between lung infection and application of high intrathoracic ... unknown. In the present review of the literature we describe the intrinsicmechanisms that explain how MV inflicts alveolar damage and the controversy regarding the use of RMs as an adjunct to MV.Finally,...

... critical analysis of the technological basis for the product and discusses itsclinical applications. The aim is to equip the reader with an understanding of the strengths and limitations of the system(Table ... formatfor future device reviews.ReviewEquipment review: An appraisal of the LiDCO™plus method of measuring cardiac outputRupert M Pearse1, Kashif Ikram2and John Barry21Specialist Registrar in ... calculateschange in stroke volume by power analysis of the firstharmonic of the arterial pressure waveform. This approachdiffers slightly from that of the PiCCO™ system; PulseCO™analyses the arterial...

... chlorpromazine induced production of the anti-inflammatory cytokine IL-10 in vivo [56]. The effects of dopamine on cytokine production are mainly mediated via βadrenoceptors because the action of dopamine ... recognized immunomodulatory effects of noradrenaline and adrenaline, the influence of dopamine oninflammatory responses are incompletely defined andcontroversially discussed. Most of our understanding ... However, clinically relevantconcentrations of dopamine also inhibit inflammation inducedupregulation of cytokines, chemokines and adhesion molecules,and induce the production of anti-inflammatory...

... replacement therapy; CVVHD = continuous veno-venoushaemodialysis; MARS = molecular adsorbents recirculating system. Critical Care August 2004 Vol 8 No 4 Boyle et al.Review Equipment review: The molecular ... but other less common causes such 281Available online http://ccforum.com/content/8/4/280What is the science underlying the technology? Molecular adsorbents recirculating system (MARSđ) therapyis ... are the costs of using the technology?ã The average number of treatments per therapy course isthree to five depending on the aetiology. The costs are onaverage between 9000€ and 15,000€ for the...

... EGDT successful as comparedwith previous attempts, and to examine other currentlyavailable markers of resuscitation.ReviewEquipment review: The success of early goal-directed therapy for septic ... the manufacturer of the SCVO2catheter.IntroductionIn 2001, Rivers and coworkers [1] reported findings from alandmark investigation of early goal-directed therapy (EGDT) for septic shock. They hypothesized ... therapy for septic shock prompts evaluation of current approaches for monitoring the adequacy of resuscitationScott R Gunn1, Mitchell P Fink2and Benjamin Wallace31Departments of Critical Care...

... affects the solid organs. The probability of being injured as a result of each of thesemechanisms is determined by the distance of the casualtyfrom the epicenter of the explosion and whether it ... door of the ED. Another experienced general surgeon acts as the ‘surgical command officer’ who guides the trauma teams. The command team maintains a log of the most severely injuredvictims. They ... the PACU. Fifty-sevenpatients were admitted from the operating rooms (56%), 11from the angiography suite (10%) and the rest were admitteddirectly from the ED (34%). The average time from the...

... controlled for the limitations noted above when evaluating the ability of the SIGto predict mortality. The findings of these two studies areunique in the sense that they are the first reports of SIGpredicting ... (predominatelyalbumin) and phosphates. The total charge of these mustequal the SIDa. The product of all of the measurable anionscontributing to the balancing negative charge is referred to as the ... that of sodium reduces the SID,resulting in a reduction in the alkalinity of blood. The Na+/Cl – ratio has been proposed as a simple way to delineate the contribution of chloride to the degree...

... beneficial in the context of the regulation of the inflammatory response [57].Heparin can inhibit the influx of neutrophils into certaintissues and inhibit T-cell trafficking, partly by an inhibitoryeffect ... anti-inflammatory effects of heparin aremediated, at least in part, by interference with the chemokinesystem [18].Therapeutic aspects of heparin The effectiveness of heparin in blocking fibrin ... course of lung injury. Thus, we hypothesize that in the early phase of lung injury collagen fibre synthesiscould be beneficial in avoiding the rupture of glycosaminoglycans, minimizing interstitial...

... ultimatelyadmitted to the ICU.ReviewClinical review: The role of the intensive care physician in mass casualty incidents: planning, organisation, and leadershipPeter J Shirley and Gerlinde ManderslootRoyal ... of these processes. Intensive care medical response: 7 July 2005Initial intensive care unit physician responseFive senior intensive care doctors were in the hospital at the time the major incident ... [17,18].Reflection and debriefing The problems we faced following the events of July 2005were not unique and are seen on an ongoing basis in otherparts of the world, including settings of insurgency warfare,such...

... standard of care in the next few years.Indicators of prognosisCAP is the leading cause of death from infection in west-ern countries [43]. Ideally, the management strategy and nature of the ... Christ-Crain M, Opal SM: The role of biomarkers in the diagnosis and management of community-acquired pneumonia. Critical Care 2010, 12:203. Page 4 of 11 of Simon and colleagues can mainly be explained ... clinical judgment based upon a synthesis of available clinical, physiologic and laboratory features in each patient.â 2010 BioMed Central LtdClinical review: The role of biomarkers in the...