Báo cáo khoa học: "Drotrecogin alfa (activated): current evidence supports treatment for severe sepsis patients with a high risk of death" ppsx

... 344:699-709. 3. Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, Francois B, Guy JS, Bruckmann M, Rea-Neto A, et al., for the Administration of Drotrecogin alfa (activated) in Early Stage Severe ... PROWESS of 24.97% and 75.03%, respectively. The risk ratios (RR) and odds ratio (OR) are plotted on a natural logarithm scale. n/N equals number of deaths at 28 days...

Ngày tải lên: 13/08/2014, 03:20

... DrotAA in the management of patients with severe sepsis with evidence of PF, MEN, or MD. DrotAA is approved only for adult patients with severe sepsis at high risk of death (United States Package ... DrotAA in the management of adult patients with severe sepsis with evidence of PF, MEN, or MD • DrotAA is not currently approved for treatment...

Ngày tải lên: 12/08/2014, 22:21

... commentary [2] analyzing current evidence for drotrecogin alfa (activated) (DrotAA) in the treatment of severe sepsis. Agarwal and Nath argue that our meta-analysis should have used a fixed-effects ... namely that a meta-analysis using individual patient data and adjusting for baseline covariates would be an important first step to identify appropriate patients for Dr...

Ngày tải lên: 13/08/2014, 03:20

... Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) study [1], Abraham and colleagues assessed the role of DrotAA in patients with severe sepsis and low risk of ... risk of death. Based on these results, in 2001 the United States and European drug regulatory agencies approved DrotAA for use in adult patients with severe...

Ngày tải lên: 13/08/2014, 03:20

Ngày tải lên: 13/08/2014, 03:20

... comprehensive data base for long- term temporal analyses of 3D conformal adjuvant radiotherapy. The specific aspect of age has been neglected by traditional research. Therefore, the impact of age on acute ... G, Berclaz G, Altermatt HJ, Greiner RH: Can the addition of regional radiotherapy counterbalance important risk factors in breast cancer patients with extracapsular invas...

Ngày tải lên: 09/08/2014, 09:20

... pharmacologic intervention for acute pancreatitis. Death from acute pancreatitis remains a major issue, and late deaths are often related to haemorrhage and are associated with unresolved intra-abdominal ... clinical sepsis. Modulation of the coagulation cascade, although probably essential to the mode of action of drotrecogin alfa, can lead to an increased risk of bleeding....

Ngày tải lên: 12/08/2014, 22:22

... secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care 2006, 10:R42. 8. Harrison DA, Brady AR, Rowan K: Case mix, outcome and length of stay for admissions ... anal- ysis plan was agreed a priori. Use of DrotAA Rate of use of DrotAA, both in patients with severe sepsis and across critical care units, was calculated....

Ngày tải lên: 13/08/2014, 10:20

... percent of patients with a GCS <13 and 45% of patients with a GCS ≥ 13 had increased S100B levels. Patients with a GCS <13 had significantly higher APACHE II scores, baseline SOFA scores and higher baseline ... mortality in adult patients with severe sepsis [3]. Survival rate was highest in the most severely ill patients and largely driven by a more rap...

Ngày tải lên: 13/08/2014, 20:21

... evaluate the dose and duration of drotreco gin alfa (activated) treatment using serial measurements of protein C compared to standard therapy in patients with severe sepsis. Methods: This was a ... or conduct of the study. All authors participated in the analysis and interpretation of data, with YZ performing the statistical analysis, and all authors helped draft, crit...

Ngày tải lên: 14/08/2014, 07:21