Báo cáo khoa học: "The role of body mass index and diabetes

Báo cáo khoa học: Afﬁnity puriﬁcation-mass spectrometry Powerful tools for the characterization of protein complexes ppt

... pathways and the functional context in which proteins operate in a variety of organisms and cell types. The specificity of affinity chromatography and the sensiti- vity and certainty of MS based protein ... define the beginning and the end of the determined sequence. Information on peptide sequence, peptide mass and fragment mass can be queried simultane...

Ngày tải lên : 31/03/2014, 07:20

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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... days in the differenti- ation medium: DMEM containing 10% fetal bovine serum and IDM (10 lgÆmL )1 insulin, 1 lm dexamethasone, and 0.5 mm IDM). Cells were then maintained in DMEM containing ... biologically relevant role of miR-27 in the regulation of adipose tis- sue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice....

Ngày tải lên : 18/02/2014, 08:20

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Tài liệu Báo cáo khoa học: A role for the intersubunit disulﬁdes of seminal RNase in the mechanism of its antitumor action docx

... mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing action of the cytosolic RNase inhibitor, a resistance due to the dimeric structure of the enzyme. ... to the surface of SVT2 cells and is internalized inside the cells, whilst the MCM monomer does not bind and is not internalized [11]. We repeated thes...

Ngày tải lên : 20/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx

... molecule comprising Ôresidues in the protruding domain consisting of the type VI b-turn and the ﬁrst part of b-strand 3Õ (i.e. the b-hairpin loop and part of the adjoining b-sheet) and Ôresidues in the loop ... obtained by other groups who also point to the role of the connecting loop of the b-hairpin of defensins. A combination of mutational analys...

Ngày tải lên : 20/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf

... region of aromatic stacking between Trp169 and His210 (Fig. 1). The two aromatic planes stack at a distance of 3.5 A ˚ , and the shortest distance between the imidazole ring of His210 and the atoms ... orientation of the imidazole–indole pair formed between Trp169 and His210 is the ﬁrst case found in the active sites of serine proteases. Although the rol...

Ngày tải lên : 21/02/2014, 03:20

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Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx

... pregnenolone synthesis in recombinant yeast. In conclusion, the SCC reaction appears to be regulated similarlyinyeastandinadrenalcells;inthelatter,Adxpand not Adrp limits the activity of CYP11A1 and hence ... results in an increased level of free sterol (Fig. 4B), and it would also be expected to increase the cycling of sterols by esteriﬁcation and hydrolysis, result...

Ngày tải lên : 08/03/2014, 08:20

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Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf

... expressed both in yeast and in T. reesei, was practically inactive. Also, the kinetic parameters were altered. The change of only one amino acid in the C-terminus of the laccase, giving the Tr(L559G) and ... preventing binding of oxygen. We analyzed the azide inhibition and determined the inhibition constants for sodium azide, in order to see the effect...

Ngày tải lên : 16/03/2014, 00:20

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Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt

... its NH 2 -terminal region, as well as an Mre11-binding domain and an ATM-binding domain in its COOH- terminal region (Fig. 1). FHA and BRCT domains are often present in eukaryotic nuclear proteins involved in ... damage, thereby promoting ATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required fo...

Ngày tải lên : 16/03/2014, 13:20

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Báo cáo khoa học: Functional role of the linker region in puriﬁed human P-glycoprotein pot

... Identiﬁcation of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine- scanning mutagenesis and inhibition by dibromobi- mane. J Biol Chem ... is shown in light pink and the other (subunit B) is shown in gray. (A) Side view of the diagrams. The C-terminal a-helix of subunit A is shown in red and the N-t...

Ngày tải lên : 29/03/2014, 23:20

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Báo cáo khoa học: Functional role of Bb-chain N-terminal fragment in the ﬁbrin polymerization process pdf

... in the fibrin bC-domain [7]. The ‘B’–‘b’ pairing leads to structural rearrangements in the D-domain and the strengthening of protofibril lateral contacts [9,10]. Many indirect data show that other ... Medved L (2002) Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the...

Ngày tải lên : 30/03/2014, 03:20

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Báo cáo khoa học: "The role of body mass index and diabetes in the development of acute organ failure and subsequent mortality in an observational cohor" doc

Báo cáo khoa học: Afﬁnity puriﬁcation-mass spectrometry Powerful tools for the characterization of protein complexes ppt

Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt