Báo cáo khoa học: "Pro/con debate: Antifungal prophylaxis is important to prevent fungal infection in patients with acute necrotizing pancreatitis receiving broad-spectrum antibiotics" docx

... clearly insufficient to support evidence-basedrecommendations about antifungal prophylaxis in acute pancreatitis. However, according to the preceding argu-ments, I would recommend adding antifungal ... adding antifungal prophylaxis with a triazole compound in any patients receiving antibacterial prophylaxis. This prophylaxis may not only prevent infection of necrotic pancreatic tissue, but also ... Ostrosky-Zeichner clinical predictionrule [20] defines patients with pancreatitis (with central linesand receiving broad spectrum antibiotics) as being at highrisk for fungal colonisation. Incorporation...

Báo cáo khoa học: "The effect of external beam radiotherapy volume on locoregional control in patients with locoregionally advanced or recurrent nonanaplastic thyroid cancer" ppsx

... techni-ques in 6 (26%) patients who were difficult to obtain theadequate target coverage within the normal tissues con-straints with 3DCRT. When the 3DCRT was used fortreating the initial target ... Eighteen (78%) patients, including 4 with unresectable disease, had gross residual disease, two(9%) patients had microscopic residual disease, andthree (13%) patients had n o residual d isease. After ... medical history, physicalexamination, routine blood counts, serum chemistry,and imaging studies including neck ultrasound (US),computed tomog raphy (CT) and/or magne tic resonanceimaging (MRI)...

báo cáo khoa học: "Isolation of specific and biologically active peptides that bind cells from patients with acute myeloid leukemia (AML)" doc

... maintained in RPMI 1640/20% FBS. Cellswere induced to differentiate into the granulocytic lineageby treatment with 1.5% (v/v) of DMSO during 7 days ofculture.Isolation of phage binding to ... thatbind only to AML cells and not to normal cells includingnormal CD34+ cells. Cytochemistry studies showed thatafter surface binding, these two peptides were internalizedwithin minutes. Intracellular ... obtained patient spec-imens for the initial screening, and in order to avoid iso-lating patient specific peptides, the screening andprofiling were performed with cells from multiple patients with...

Báo cáo y học: "Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials" ppt

... minute ventilation in patients with ARDS, at least initially. This is likelyrelated to the fact that most patients enrolled in ALI/ARDS datasets are sedated with minimum activity,receive minimal ... significance in patients with ALI and ARDS, but is not routinely mea-sured in clinical practice.• In me chanically ventilated patients with ALI andARDS, Vd/Vt can be estimated from routinely availableclinical ... methods for calculating metabolic rate with specialreference to protein metabolism. J Physiol 1949, 109:1-9.15. Weissman : Measuring oxygen uptake in the clinical setting. In Oxygentransport...

Báo cáo y học: " Effect of oral beta-blocker on short and longterm mortality in patients with acute respiratory failure: results from the BASEL II-ICU study" ppt

... found in our patients including history of CAD in 38%, history of CHF in 27%, arterial hypertension in 53% and COPD in 39% and the positive effect of beta-blocker therapy in these different diseases. ... difficult to perform in ICU patients pre-senting with acute respiratory failure, this finding maybe of major clinical importance. Roughly one-third o four patients were treated with beta-blockers ... thatare tolerated by patients without ischemia, particularlyat high heart rates [44]. The most suitable explanationfor this conflicting finding in our study is that patients with acute coronary...

Báo cáo khoa học: Crystal structure of the halotolerant c-glutamyltranspeptidase from Bacillus subtilis in complex with glutamate reveals a unique architecture of the solvent-exposed catalytic pocket docx

... protein to remain in a hydratedstate, preventing the binding of inorganic cations in thehigh-salt solution, and also preventing self-aggregation.B. subtilis GGT may be applicable to the manufac-ture ... C-terminus, weembarked on a crystallographic analysis of B. subtilisGGT in complex with glutamate.Another goal of this analysis was to determine thestructural factors underlying the salt tolerance ... completelydisappeared. The negatively charged areas of B. subtilisGGT under high-salt conditions even increased thesolvation, owing to increased water-binding capacity.This may allow the protein to...

Báo cáo khoa học: Substrate positioning by His92 is important in catalysis by purple acid phosphatase docx

... proposed to be involved in substrate binding: themetal coordinating Asn91, and the nonmetal coordina-ting His195 and His92 (numbering is according to thehuman PAP sequence [21]). Mutagenesis of His195 ... three-fold increase in kcatofthe His92Asn mutant compared to the wild-typeenzyme is particularly surprising. The shift of pKa,1 to lower pH upon mutation of His92 into Ala and theincrease in kcatfor ... position, onethat is less favorable for catalysis. To gain better insight into the structural effects ofthe mutations, ﬁrst approach models with energyminimization were obtained using SwissModel andDeepView...

Báo cáo khoa học: "Scaling up from the individual tree to the stand level in Scots pine. I. Needle distribution, overall crown and root geometry" ppsx

... in 1980, decreasing to 899 trees ha-1 in 1987, 743trees ha-1 in 1990 and 716 trees ha-1 in 1993.Due to windfall a remaining 672 trees ha-1were still present in ... multiplying the val-ues with the corresponding numbers oftrees in each class, are shown in figure 9.This upscaling results for the Scots pinestand of this study in a ... RESULTS AND DISCUSSION3.1. Forest inventoryThe forest inventory data (recorded in spring 1995), all expressed per ha ofground area, are summarized in table II.Stocking density...

Báo cáo khoa học: "Laparoscopic insertion of pelvic tissue expander to prevent radiation enteritis prior to radiotherapy for prostate cancer" pdf

... Wound infections associated with large lapar-otomy incisions are not uncommon, particularly whenthe incision extends into the radiation field[19]. Theother disadvantage of tissue expanders, is ... mm iliac fossa incisions.Figure 3 Insertion of tissue-expander through medium Alexis®ring retractor in the 20 mm supra-pubic incision: this wasfacilitated by prior lubrication with water-soluble ... with the distal tip packed into thepelvis[7]. This is particularly suitable during open color-ectal surgery where mobilisation of the omentum off thecolon is required. But this procedure is...

Báo cáo khoa học: "Volumetric modulated arc therapy is superior to conventional intensity modulated radiotherapy a comparison among prostate cancer patients treated in an Australian centre" pps

... treating with 3D to RA. Over 350 patients havenow been treated with this new technology in this cen-tre. This study is an audit o f the RA exper ience to ensure that the newer therapy is recommended ... radiotherapy, total beam times,monitor units and acute rectal toxicity of the first 30prostate patients treated with RAIndicationForRadiationNo Of Patients TotalBeamtime(minutes)TotalMonitorUnits Acute ... RA is summarized in Table 6.Discussion In our audit, 30 prostate cancer patients treated radically with RA by one radiation oncologist were found to betreated with acceptable toxicity. In re-planning...

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