Báo cáo khoa học: "Drotrecogin alfa (activated): down and not out, but not really in eithe" ppt

... on consistent clinical trials and should not depend on the use of a Letter Drotrecogin alfa (activated): down and not out, but not really in either Jan O Friedrich 1 , Neill KJ Adhikari 2 and Maureen ... identifying such patients. We agree with Agarwal and Noth’s [1] second point, namely that a meta-analysis using individual patient data and adjusting for basel...

Ngày tải lên: 13/08/2014, 03:20

... enrolled in the dose- escalation phase of EVAO were not included in the present investigation [29]. Study investigators adhered to good clini- cal practices and ethical principles as stated in the ... thromboplastin time; BL, baseline; DrotAA, drotrecogin alfa (activated); ICH, intracranial hemorrhage; PT, prothrombin time; UD, unknown day after infusion. A dash indicates missing...

Ngày tải lên: 12/08/2014, 22:21

... demonstrating a risk ratio using weights for ADDRESS and PROWESS of 18.17% and 81.83%, respectively; method 2, a random effect model demonstrating a risk ratio using weights for ADDRESS and PROWESS ... number of studies and a p-value < 0.05, indicating heterogeneity. A point estimate to the left of the line of identity (1) favors treatment with Drotrecogin alfa (activated) and...

Ngày tải lên: 13/08/2014, 03:20

... low- dose heparin [3]. In the Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) study [1], Abraham and colleagues assessed the role of DrotAA in patients with ... differences in 28-day or hospital mortality between groups, but rates of serious bleeding were greater in the DrotAA group both during the infusion (2.4% vs. 1.2%, P=0.02) an...

Ngày tải lên: 13/08/2014, 03:20

Ngày tải lên: 13/08/2014, 03:20

... of inflammation. Activation of protein C by thrombin-dependent endothelial binding inhibits thrombin generation and stimulates fibrinolysis [6]. In addition, activated protein C has anti-inflammatory ... drotrecogin alfa, can lead to an increased risk of bleeding. Objective The findings of the PROWESS trial have led to a more widespread use of drotrecogin alfa in sepsis and, critica...

Ngày tải lên: 12/08/2014, 22:22

... and out- comes for patients receiving DrotAA were described. Details relating to the infusion of DrotAA, including time to initiation, duration and interruptions, were described. Type, site and characteristics ... sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 2003, 31:2332-2338. 12. Bone RC, Balk RA, Cerra FB,...

Ngày tải lên: 13/08/2014, 10:20

... bind- ing of APC on endothelial and inflammatory cell recep- tors exerts pleiotropic in vitro intra- and intercellular effects, altering gene expression profiles, inhibiting apop- tosis and down- regulating ... to use in routine and the relationship between the degree of SEP impairment and corresponding S100B levels in SAE remains to be determined. Cerebrospinal fluid assay...

Ngày tải lên: 13/08/2014, 20:21

... approaches, top- down and left-corner parsing, and find both to be viable. In addition, we find that enhance- ment with non-local information not only im- proves parser accuracy, but also substantially ... remaining on the pending heap are discarded. The success heap then becomes the pending heap, and the look-ahead is moved forward to the next item in the input string....

Ngày tải lên: 20/02/2014, 19:20

... complexes. (B) Changes in cell shape and the plasma mem- brane during mitosis and dendrite extension. (C) An increase in intracellular [Ca 2+ ] in only one of two adherent cells does not disrupt cell–cell ... kinase, and the cytoskeleton. Cell Signal 18 , 1932–1940. 30 Cao Z, George J, Baden DG & Murray TF (2007) Brevetoxin-induced phosphorylation of Pyk2 and Src in muri...

Ngày tải lên: 16/02/2014, 09:20