Báo cáo y học: "Polarized expression of the membrane ASP protein derived from HIV-1 antisense transcription in T cells" potx

... very recent results sup port the notion that epitopes derived from antisense transcripts s erve as CD8 T- cell targets in HIV-1 infection [21]. Taken together, all these data s uggest that the HIV-1 ... CTCCA- CAATTAAAACTG-3’ (sense) and 5’-GTCCATGGCTG- TAATTCAACACAACTGTTTAATAGTAC-3’ (anti- sense). Primers permitting the addition of a Flag tag at the COOH end of the...

Ngày tải lên: 13/08/2014, 01:21

... CAG T CAT GCT AAG AAT TGA GTT AAT AAT AGG CTC GGT TCC CTT CC Ang-2 CGC TCG AAT ACG ATG ACT CG TGC AGA GGC TGC AAG TGC TGG AGA A CCA CTG AGT GTT GTT TTC CAT GAT Tie1 GCC ACG TTC TGG CTG GAT TCA ... CTC CTC AGC TGT GGC AT ACT TCA CTT ACG CGG GCA TT Tie2 GGC AAC TTG ACT TCG GTG CT ACT TAC ATC CCA GGG AGC AGT ACG TGG TC GGC CTT GGT GTT GAC TCT AGC T Arthritis Research Vol 4 No 3 Shahrara et ....

Ngày tải lên: 09/08/2014, 03:24

... involved in integrin αvβ3-mediated bone resorption [19,34-36]. Interestingly little is known about the activation of these proteins in RA ST. In this study we demonstrated the phosophorylation of FAK ... nonreceptor protein tyrosine kinases that are acti- vated by a variety of extracellular stimuli [1]. FAK and Pyk2 associate with the cytoskeleton and with integrin-signali...

Ngày tải lên: 09/08/2014, 10:21

... specific activity than when activated by APMA (4-aminophenylmercuric acetate), trypsin or plasmin [19,25,33]. Such potent activation of these proteins can therefore shift the balance of activity in favour ... pathways, including analysis of enzyme activities, is required to better understand the underlying pathogenesis. Competing interests The authors declare that they have no c...

Ngày tải lên: 09/08/2014, 14:22

... N-acetylation and the chymotrypsin-like activity of 20S proteasome. In the present s tudy, we detec ted the N-acetylation of OsRpt6 in the rice RP complex by MS. Other N-terminal modifica- tions ... them in both cytoplasm a nd nucleus of eukaryote is ubiquitin-proteasome pathway that involves the covalent attachment of polyubiquitins to substrate targeted for degradatio...

Ngày tải lên: 08/03/2014, 16:20

... rate of protein synthesis in these studies. These data are consistent with the notion that phosphorylation of eIF4E does not affect its interaction with eIF4G and indicates that it is also insufficient ... pathway to stimulate protein synthesis. The authors argue that the inhibitory effect of Mnk activity on cap-dependent translation may act to limit translation under certain...

Ngày tải lên: 23/03/2014, 21:20

... hypothesis was validated both in vitro and in vivo, in that arthritic fibroblasts exhibited F- actin stress fibres that were most probably due to the increased adhesion to the substratum (extracellular matrix). ... severity of subsequent disease course. After 2 years joint erosions are seen in most patients, and most patients become clinically disabled within 20 years. A recent...

Ngày tải lên: 09/08/2014, 01:23

... Table 3, right column) suggests that WR1065 did not inhibit the antiretroviral activity of AZT. On the contrary, combination of WR1065 with AZT did increase the antiretroviral efficacy of AZT. Anti-SIV ... (apoptotic) and negativity (non-apoptotic). Flow Cytometry for determination of cell cycle parameters in human TCBs cultured in the presence of WR1065 Flow cytometry w...

Ngày tải lên: 10/08/2014, 05:21

... of the inferior gluteal artery caused by NTS occurring in an adult Kenyan man infected with HIV. To the b est of o ur knowledge, this report represents the fir st of its kind in the medical literature. * ... with evidence of intra-luminal clot. His hemoglobin was 12.9 g/dl. The bloody aspirate, obtained prior to the administ ration of antibiotics, was sent for cultur...

Ngày tải lên: 11/08/2014, 03:21

... distribut ion, and reproduction in any medium, provided the or iginal work is properly cited. rarity of aneurysms of the inferior gluteal artery, the lack of trauma, instrumentation, or another ... infection. Consent Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is a...

Ngày tải lên: 11/08/2014, 07:20