Báo cáo y học: "The role of unintegrated DNA in HIV infection" docx

... Taiwan; 3 Department of Pharmacy and Pharmacology, The University of Bath, UK Deacetoxycephalosporin C synthase (DAOCS) catalyses the oxidative ring expansion of penicillin N, the committed step in the biosynthesis ... type of mutant, represented by arginines 306 and 307, are located in the C- terminus. They appear to modulate the activity of the C- t...

Ngày tải lên: 18/03/2014, 01:20

... their role in bone metabolism and repair remains unclear. Review of the evidence To determine the role of COX-2 in bone repair, investiga- tors have studied fracture healing in animal models of COX-2 ... 17:963-976. 11. Einhorn TA. Do inhibitors of cyclooxygenase-2 impair bone healing? J Bone Miner Res 2002, 17:977-978. 12. Zhang X, Schwarz EM, Young DA, Puzas JE,...

Ngày tải lên: 09/08/2014, 01:21

... and in the pathogenesis of OA. Keywords: cartilage, chromosomes, genetics, linkage, osteoarthritis Review The role of structural genes in the pathogenesis of osteoarthritic disorders Anthony M ... the genes encoding these structural components of the matrix have provided insight into the function of the individual gene products in the pathogene...

Ngày tải lên: 09/08/2014, 06:22

... 2 Immunopositive staining for the IL-1 family in human intervertebral discsImmunopositive staining for the IL-1 family in human intervertebral discs. Numbers of cells with immunopositivity for IL-1α ... staining for phenotypic markers in chondrocyte-like cells from human intervertebral discsImmunopositive staining for phenotypic markers in chondrocyte-like cells from...

Ngày tải lên: 09/08/2014, 06:22

... conditions. Using RNA-interference, Yudoh and colleagues [1] further analyzed the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival. During hypoxic and normoxic ... cell death induced by pro-inflammatory cytokines. Finally, Yudoh and colleagues showed that HIF-1α is necessary for anaerobic energy generation and proteoglycan synthesis by...

Ngày tải lên: 09/08/2014, 07:20

... therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade. J Pharmacol Sci 2006, 100:9-16. 23. Teplitsky V, Shoenfeld Y, Tanay A: The renin-angiotensin system in lupus: physiology, ... [10-12]). Aldosterone also exerts proinflammatory effects in the kidney and other tissues [13,14], such as leuko- cyte infiltration and increased expression...

Ngày tải lên: 09/08/2014, 10:22

... declared expectation of only slight knee pain after surgery. In reality, only 43% of the group reported being pain-free at 2 years post operation. The patients were similarly overly optimistic about ... satisfaction after TKA were determined by prior expectations of the outcome, by expectations being met, or by the actual symptom/functional status after surgery. Studies s...

Ngày tải lên: 09/08/2014, 14:22

... respectively. The grey boxes show insertion of TEs into exons. The TE family is indicated beneath the gray box, along with the length of each inserted TE. Lengths of the introns and exons flanking the ... [46,47,53]. Presumably, the increase in the size of the last exons and in the percentage of TEs within these exons from inverte- brates to mammals may...

Ngày tải lên: 09/08/2014, 20:22

... Genome Biology 2011, 12:R12 http://genomebiology.com/2011/12/2/R12 Page 3 of 10 RESEARC H Open Access The role of codon selection in regulation of translation efficiency deduced from synthetic libraries Sivan ... capacity of codon selection to affect translation efficiency, particularly since these models ignore codon order that is under tight selection...

Ngày tải lên: 09/08/2014, 22:23

... Access The role of traditional healers in tooth extractions in Lekie Division, Cameroon Ashu M Agbor 1* , Sudeshni Naidoo 1 and Awono M Mbia 2 Abstract Background: The extraction of the teeth by traditional ... skele- tons of Early Iron Age populations (ca. 1500 years before present)[3]. Traditional healers in Africa have been carry ing out surge ry ranging fro...

Ngày tải lên: 10/08/2014, 09:21

... year experience in clinical treatment of thymomas as a result of a retrospective single centre analysis done within a Euro- pean university setting. The role of a pseudocapsula and its clinical significance ... metasta- sis in the liver. Recurrence was only seen in one case each in patients with an incomplete encapsulated thymoma or a missing capsula. Neo...

Ngày tải lên: 10/08/2014, 10:20

... further hydroxylated at position 1a by the mitochondrial cytochrome P450 enzyme 25-hydro- xyvitamin -D- 1a-hydroxylase (gene name: CYP27B1) and converted to the bioactive 1a,25- dihydroxyvitamin D (1,25-(OH) 2 D 3 ). ... enzymes CYP27A1 and/ or CYP2R1 and subsequently by the cytochrome P450 enzyme 25- hydroxyvitamin D- 1a-hydroxylase (CYP27B1) and converted to the bioactiv...

Ngày tải lên: 12/08/2014, 13:22

... hyperresponsiveness and exhibit an attenuated inflammatory response. The contri- bution of γδ T cells to epithelial regeneration in the intes- tine is not evident in the airways. Competing interests The author(s) ... exposure to chlorine (Cl 2 ) gas causes epithelial injury and airway dysfunction. γδ T cells are present in the mucosal surface o...

Ngày tải lên: 12/08/2014, 15:20

... mice [46]. Conclusion In summary, the results of the present study yield evidence of the involvement of ET-1 in the lung function changes induced by hyperoxia. The highly dissociated effects of oxygen toxicity on ... air- way effects of hyperoxia. As regards the tissue mechanical parameters, the most noteworthy finding in the present study is the ability o...

Ngày tải lên: 12/08/2014, 16:20

... from unintegrated HIV DNA The primary function of unintegrated DNA in the HIV replication cycle is to provide the link between viral RNA and integrated proviral DNA, in the form of linear cDNA ... translation of unintegrated DNAs prior to integration may aid productive infection through the expression of early viral genes. Additionally, unintegrated DNA has the...

Ngày tải lên: 13/08/2014, 01:21