Báo cáo y học: "Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef’s functionality in primary macrophage" pptx

... article as: Mwimanzi et al.: Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef s functionality in primary macrophages. Retrovirology 2011 8:50. Submit ... reduced the cytolytic activity of VY8-specific CTLs i n the context of CD4 + T cells [13], but did not affect their cytolytic activity in the context of MDMs...

Ngày tải lên: 13/08/2014, 01:21

... data is that daily dosing of rhGH with HAART, in addition to improving HIV- 1-associated lipodystrophy, may reverse some of the T- lymphocyte dysfunction seen in most treated HIV- 1-positive patients, ... promotes the restoration of T- cell responses against HIV- 1, a restoration that declines with cessation of treatment. Since HIV- 1 + patients com- monly develop growth...

Ngày tải lên: 11/08/2014, 10:23

... the adjuvant therapies that can help treat antibi- otic-resistant bacterial infections. In this investigation, we showed that intratracheal administration of murine mon- oclonal anti-PcrV IgG ... protective. Therapeutic administration of Mab166 intratracheally protects against P. aeruginosa-induced acute lung injury Next, we evaluated the therapeutic administration of anti- PcrV IgG...

Ngày tải lên: 11/08/2014, 10:23

... [23]. Stimulation of adenosine receptors induces an inhibitory effect on central excitability. Another interesting nutritional strategy to improve performance is the ingestion of branched-chain ... LabChart6 software (ADInstruments). The twitch interpolation technique was used to determine potential change in maximal voluntary activation [32]. This consisted in superimposing st...

Ngày tải lên: 11/08/2014, 23:21

... sections were also incubated with the primary antibody (anti-nitrotyro- sine) in the pre sence of excess nitrotyrosine (10 mM) to verify the binding specificity. To verify the binding specificity ... Bax and down-regulation of anti-apoptotic Bcl-2, using western blot assa y and by immunohistochemical staining. We report in the pre- sent study for the first time that the treatm...

Ngày tải lên: 12/08/2014, 11:20

... IL-27 stimulation could lead to receptor-medi- ated tyrosine phosphorylation of the STAT family [52]. Our study showed that incubation with IL-27 resulted in STAT1 tyrosine phosphorylation within ... impli- cated in the pathogenesis inflammation in RA by the induction of the infiltration of leucocytes into local joint [32]. Because of the pivotal role of ICAM-1 and VCAM-1 i...

Ngày tải lên: 12/08/2014, 14:22

... effect by limit- ing the extent of the initial toxicity and vascular injury induced by MCTp. We first investigated whether lung cell colonization could account for the protective effects of BMDCs. ... active MCT metabolite MCT pyrrole (MCTp). In order to determine whether PH alterations were due to protection of the pulmonary vasculature by BMDCs, we used quantitative real-time PCR...

Ngày tải lên: 12/08/2014, 15:20

... and at a range of simulated alti- tudes [37]. Study limitations On the technical point of view, the main limitations of all studies based on circulating EPCs enumeration consist in the lack of ... vasodilatation of peripheral ves- sels and constriction of the vessels of the pulmonary vas- culature to shunt blood away from the poorly ventilated region. In our subjects...

Ngày tải lên: 12/08/2014, 15:21

... concentrations of pro-inflammatory cytokines. Glucocorticoid treatment of cartilage can effectively abolish matrix degradation induced by the combination of pro-inflammatory cyto- kines and injury. ... to its level in the no- treatment control group. Pathways: inhibition of glucocorticoid receptor, proprotein convertases and iNOS TheroleofchondrocyteGRsintheresponsetoDEX was stu...

Ngày tải lên: 12/08/2014, 18:20

... study was to compare pre-arrest and post-resuscitation organ perfusion values and to investigate whether, during the post-resuscitation phase, administration of the angiotensin II antagonist telmisartan ... CPR. In addi- tion, the time delay from ventricular fibrillation to restoration of spontaneous circulation may be an important period for the activation of the renin-angiotensi...

Ngày tải lên: 12/08/2014, 18:20