Báo cáo y học: "Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1" ppsx

... Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1. Retrovirology 2011 8:36. Submit your next manuscript to BioMed Central and take full advantage of: ... in miRNA profile is observed by ablation of Vpr/Vif The possibility that HIV-1 manipulation of host miRNA contributes to HIV-1 induced cell cycle delay was p...

Ngày tải lên: 13/08/2014, 01:20

... deviation of the cytokine response, caused either by decreased Th1-type cytokines and/or by enhanced Th2-type cytokines leading to the regression of an autoimmune disease, is reminiscent of other ... secretion of the anti-inflammatory cytokine IL-10 over the pro-inflammatory cytokine IFN-γ, resulting in the over- all skewing (immune deviation) of the cytokine response to an...

Ngày tải lên: 09/08/2014, 10:20

... and MTX were found to inhibit function of phagocytic cells and both monocytic/lymphocytic proinflammatory cytokines involved in rheumatoid synovitis, and this seems to be the key role in the sustained ... alleviate the symptoms and improve the quality of life. The nonsteroidal anti-inflammatory drugs and glucocorticoids are largely used for treatment of rheumatoid arthritis in spite...

Ngày tải lên: 09/08/2014, 10:21

... intravenously or intracraniall y before and after the onset of motor functio n loss. Motor function of mice was evaluated by an accelerating protocol of rotarod test every 8 weeks. Immunohistochemical ... the toxicity of the protein, influencing downstream pathways activated by the mutant protein and transplantation [4]. For symp- tom treatment, levodopa is temporarily useful fo...

Ngày tải lên: 10/08/2014, 10:20

... eigenvalue of B.Let0 <μ<1 be fixed. Starting with an initial vector x 0 , define x k ,y k ,k  0, 1, 2, ,recursively by y 0  x 0 , Q  x k    Q − A   y k−1   b, y k  y k−1   1 ... consistent, then y k ,k  0, 1, 2, ,converges to a solution vector z of Ax  b with rate of convergence given by   y k − z    o  ζ k  , 30 where ζ is any number satis...

Ngày tải lên: 21/06/2014, 20:20

... genetic by number reared, postnatal maternal by number reared or prenatal genetic by postnatal maternal by number reared effects. Interactions that were significant generally were ... oxidative phosphorylation, they are a prime candidate for cytoplasmic maternal effects contri- buting to selection response. Maternal effects associated with select...

Ngày tải lên: 09/08/2014, 22:22

... site of introduction of the dsRNA. This spread depends on the activity of an RNA- dependent RNA polymerase (RdRP), which amplifies dsRNA to produce more copies, which are then cleaved by the ... role of these small RNAs is as a defense against transposable elements. The terminal structure of piRNAs is not like that produced by Dicer [19] and so they are likely to be...

Ngày tải lên: 09/08/2014, 20:20

... connected by a loop of unpaired nucleotides. MiRNA stem loops are typically expressed as part of larger primary tran- scripts (pri-miRNAs) [44]. Artificial miRNAs more natu- rally resemble endogenous RNAi ... consisting of RNAse III enzyme Drosha and the double-stranded RNA- binding protein DGCR 8 into pre-miRNAs. These are exported from the nucleus into the cytoplasm by exporti...

Ngày tải lên: 12/08/2014, 01:22

... previously by Millington-Ward (14) who reported allele-preferential silencing of COL1A1 in COS7 cells and in primary human mesenchymal progenitor cells. The results reported by Milling- ton-Ward ... 365 vectors expressing short hairpin RNAs (shRNAs). Aptamer-shRNA chimaeras (18) may also be an inter- esting possibility to explore in order to deliver siRNAs specifically to...

Ngày tải lên: 03/11/2012, 11:52

... machinery [16] may promote the development of autoimmunity. Conclusion The identification of components of the RNAi machinery as targets of the anti-Su autoantibody system provides another example of ... death, either by apoptosis or (secondary) necrosis. Especially during programmed cell death, key regulators of gene expression are inactivated by proteolytic cleavage or other...

Ngày tải lên: 09/08/2014, 08:22