Báo cáo y học: "A Functional Role for ADAM10 in Human Immunodeficiency Virus Type-1 Replication" pptx

... metalloprotease domain, it also c ontains a disintegrin domain, an EGF- like domain, a cysteine-rich domain, a transmembrane domain, and a cytoplasmic domain [13]. ADAM10 is required in NOTCH signaling during ... slower in primary human macrophages than in a lymphoid cell line. Virology 1994, 200:114-120. 31. Bukrinsky M, Sharova N, Stevenson M: Human immunodeficiency virus ty...

Ngày tải lên: 13/08/2014, 01:20

... inflammation/joint destruction in DBA-lpr/ lpr mice in spite of the same clinical score as that of control mice. The proinflammatory cytokines including TNF-α and IL-6 have been intensively investigated ... disease by destroying target tissues through induction of apoptosis of chondrocytes [33]. Alternatively, Fas could contribute to synovial hyperplasia by inducing proliferation of Fas-e...

Ngày tải lên: 09/08/2014, 01:23

... associates with tyrosine kinases of the Janus kinase (Jak) family. Upon ligand binding the associated Jaks become activated by transphosphorylation and phosphorylate tyrosine residues in the cytoplasmic ... CBM, cytokine binding module; FNIII, fibronectin type III-like; GCSF, granulocyte colony stimulating factor; GH, growth hormone; IL, interleukin; Jak, Janus kinase; LIF, leukemia inhibito...

Ngày tải lên: 18/03/2014, 01:20

... paraformaldehyde for 4 days. After decalcification in 5% formic acid, speci- mens were processed for paraffin embedding. Tissue sec- tions (7 μm) were stained with hematoxylin and eosin (cell influx) ... centrifuged for 5 minutes at 1,000 g. Murine IL-1β, IL-6, and TNFα levels were determined using the Luminex multianalyte technology and the BioPlex system in combination with BioPle...

Ngày tải lên: 12/08/2014, 12:20

... changes in cell stiffness using magnetic twisting cytometry (MTC) and changes in cell traction force using Fourier transform traction micro- scopy (FTTM). Finally, scaling up to the level of an intact ... protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery. Journal of Physiology-London 2000, 524:865-878. 12. Komalavilas P, P...

Ngày tải lên: 12/08/2014, 13:22

Ngày tải lên: 12/08/2014, 20:21

... was evidence of excessive activity (including a premature eyeblink) during the baseline period. They were also rejected if there was no evidence of an eyeblink having been evoked by the startle probe. Altogether, ... carry insufficient infor- mation?’ was raised Bradley and colleagues. It is possible that the robustness of the film material compensates for the insufficient information. Brad...

Ngày tải lên: 09/08/2014, 01:21

... cycling condi- tions were: 94°C for 12 min, followed by 30 cycles for 18S and 40 cycles for the neurotrophins of 94°C for 30 sec, 60°C for 30 sec and 72°C for 1 min, before ending with 72°C for ... may be differently regulated by inflammatory cytokines, suggesting a dynamic interplay that might have a potential role in airway inflammation. Background Allergic asthma is chara...

Ngày tải lên: 12/08/2014, 16:20

... following day cells were incubated in hypoxanthine, aminopterin and thymidine (HAT) medium and then cloned by colony picking and expansion in complete DMEM medium. Colonies were visually scored for ... briefly selected for inducible HSV-TK expression in hypoxanthine, aminop- terin and thymidine (HAT) medium. Clonal populations were obtained by limiting dilutions and colonies were vi...

Ngày tải lên: 13/08/2014, 05:21

... identified by screening, is commonly used as a diagnostic marker, although the patho- genic role played by autoantibodies in RA remains a mystery. Fcγ receptors (FcγRs) play a pivotal role in the ... conceived the study. HZ per- formed FcγR genotyping and coordinated the statistical analy- sis. YM, TY and YK performed GPI ELISA. TH participated in clinical assessment. TS participate...

Ngày tải lên: 09/08/2014, 07:20