Báo cáo y học: "Antiviral activity of a-helical stapled peptides designed from the HIV-1 capsid dimerization domain" pps
Báo cáo y học: "Antiviral activity of Engystol® and Gripp-Heel®: an in-vitro assessment" pptx
... of MedicalVirology and Epidemiology of Virus Diseases of the Hygiene Institute at University of Tübingen, respectively.For IFN assaysHeLa cells (University of Jena, Germany) were incubatedwith ... Gripp-Heel® inhibited the replication of a variety of respiratory viruses. Additionally, weshowed that pre-incubation affects the magnitude of the inhibitory effect differently for the various tested ... goodtolerability and lack of any known adverse effects [2,5]. The established clinical efficacy, yet not clarifiedmechanism of action of the two preparations, formed the objective of our studies...
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Báo cáo y học: "Antiviral activity of a-helical stapled peptides designed from the HIV-1 capsid dimerization domain" pps
... in core assembly being reversible byVSV-G pseudotyping [75].Anti -HIV-1 activity and cytotoxicity of stapled peptides incell-based assaysWe measured the anti -HIV-1 activity of NYAD-201 andits ... Montelaro (University of Pittsburgh).Synthesis of stapled peptides The peptides were synthesized manually by Fmoc solidphase synthesis as described previously [59].CD spectroscopyCD spectra were ... isolates. The cytotoxicity of the stapled peptides was assessedby the XTT method in both MT-2 cells and PBMC.Cytotoxicity assays were performed in parallel with the HIV-1 inhibition assays. The CC50(concentration...
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Báo cáo Y học: Bromoperoxidase activity of vanadate-substituted acid phosphatases from Shigella flexneri and Salmonella enterica ser. typhimurium doc
... BSA as the standard.Enzymatic assay of phosphatase activity The phosphatase activity was measured by hydrolysis of 10 mMp-nitrophenyl phosphate as a substrate in 100 mMMes (pH 6.0). The reaction ... mMH2O2on a Cary 50 [23]. The kinetic parameters were determinedusing the ENZYMEKINETICSprogram from Trinity Software.Assay of PhoN-Se brominating activity. The brominating activity of PhoN-Se ... for the substrate but is not optimized for phospha-tase activity. On the basis of the similarity of the active sitesand the fact that the phosphatase activity of phosphatases isinhibited by...
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Tài liệu Báo cáo Y học: A family of expressed antifreeze protein genes from the moth, Choristoneura fumiferana ppt
... freezing.During the winter they also increase the concentration of the cryoprotectant, glycerol, 10-fold and desiccate to 40% of the prediapause water content [4]. Taken together,these adaptations may explain ... Denhardt'ssolution for a minimum of 12 h [19]. To examine the complexity of the gene family, the blot was hybridized with the 337 isoform probe and washed u nder low stringency ( 0.1MNa2HPO4/5% ... any other stage. As p reviously mentioned t here were fourpotential polyadenylation sites identi®ed in 2.7a. Assumingthatthegenehasa5¢ exon and 5¢ UTR of roughly t he samelength as the other...
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Báo cáo y học: "Nutritional management of Eosinophilic Gastroenteropathies: Case series from the community" doc
... patients who choose this type of therapy include limitations due to the cost of repeated endoscopies, palatability of elimination/elemental diets and the availability of subspecialists trained ... eosinophil/HPF in the distalesophagus. Corn and eggs were introduced and stoppedbecause they caused symptoms to return. Three weeksafter the reintroduction of cow’s milk, wheat and soy, abiopsy of the ... eosinophils/HPF. Despite the high eosinophil count, the patient didnot complain of any symptoms. The patient discontin-ued the consumption of cow’s milk, wheat and soy anda repeat biopsy performed a...
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Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
... suppressor activity. The PR domain of RIZ1 possessed anticancer activity from the transfec-tion studies. This finding leaves us an important question on the roles the other structural components of ... anticancer activity. In this study, we quan-titatively analyzed the mRNA expression level of RIZ1 over the disease progression in eight different types of cancer, and evaluated the anticancer activity ... supported from a research grant from the Cancer Research Society of Canada. W. Sun would also like to acknowledge the College of Phar-macy and Nutrition, University of Saskatchewan for the awarding...
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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
... related cytopenias. The use of these agents is costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are ... with the latest combination therapy. However, existing data support therapy of the patient with compensated cirrhosis. Cirrhotic patients may tolerate therapy less well, given the propensity ... combination therapy. Hepatology 2004;40:1450-8. 15. Crippin JS, McCashland T, Terrault N, Sheiner P, Charlton MR. A pilot study of the tolerability and efficacy of antiviral therapy in hepatitis...
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Báo cáo Y học: Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein–protein interactions pdf
... systematicanalysis of the role played by the two sets of Ser/Thrresidues in the virus-dependent activation of IRF-3. To thisend, we examined the phenotypes of a variety of hIRF-3mutants by ... none of the IRF-3constructs activated the reporter in the absence of mCBP,suggesting that IRF-3 by itself is devoid of intrinsictranscriptional activity. Fig. 2. The transcriptional activity of ... however, the activity of Gal4-IRF-3A5 was significantly strongerthan that of the WT construct, but importantly, was stillvirus-inducible. IRF-3E5 displayed strong basal activity, which was further...
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Báo cáo Y học: Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates docx
... amidolytic activity was obtained by showing thatcommercial PAP hydrolysed the Abz-ISYQSSSTEEQ-EDDnp substrate at neutral pH, as does the puri®edenzyme. The ratio of the amidolytic activity of ... at the elution time of PSA was observed; (d) commercial PAP has amidolytic activity similar to that of puri®ed PAP. The fact that there was a shift in the cleavage of synthetic peptides by PAP ... glutamine was the C-terminal residue of all peptides due to a requirement of the synthesis strategy [12]. All syntheses were performedwith Fmoc methodology using a multiple automatedpeptide synthesizer...
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Báo cáo y học: " Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo" pptx
... days 3, 7, 10, 14and 17.ResultsAnti -HIV-1 activity and cytotoxicity of WR1065 in human TCBsIn HIV-1- infected human TCBs, the HIV-1 titers, deter-mined in the absence of drug, ranged from ... treated the cells and performed the cytotoxicity assays and immunoassays for virus titer. OAOprovided important conceptual input regarding the cyto-toxicity assays. GF provided the monkey cells ... to HIV-1. The mechanism(s) that may contribute to the antiretrovi-ral efficacy of these drugs are still largely a matter of con-jecture. One possible explanation comes from the importance of...
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