Báo cáo y học: "trong mucosal immune responses in SIV infected macaques contribute to viral control and preserved CD4+ T-cell levels in blood and mucosal tissues" pps
Báo cáo y học: "trong mucosal immune responses in SIV infected macaques contribute to viral control and preserved CD4+ T-cell levels in blood and mucosal tissues" pps
... determined in blood and all mucosal sites by quantifying viral RNA and proviral DNA load.ResultsBaseline characteristics of SIV infected RMThis study included 30 SIV- infected rhesus monkeys ofIndian ... Schultheiss et al.: Strong mucosal immune responses in SIV infected macaques contribute to viral control and preserved CD4+ T-cell levels in blood and mucosal tissues. Retrovirology 2011 8:24.Schultheiss ... opportunity to inves-tigate 14 SIV- infected RM of Indian origin, which havebeen effectively suppressing systemic viral load for sev-eral years (controllers) in comparison to uninfected ani-mals and...
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Báo cáo y học: " CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection" pps
... recruitment com-pared to controls (Fig. 2B and 2C).DsRNA induces increased lung injury To determine if the influx of neutrophils into lung airways and parenchyma results in lung injury, we measured ... Respiratory viral infections are characterized by the infiltration of leukocytes, includingactivated neutrophils into the lung that can lead to sustained lung injury and potentially contribute to chronic ... cell line with rhinovirus. Induc-tion of cytokine release and modulation of susceptibility to infection by cytokine exposure. J Clin Invest 1995, 96:549-557.12. Schroth MK, Grimm E, Frindt P,...
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Báo cáo y học: "Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy" pps
... the loss of CD4+ T cells in HIV-1 infected patients. Infected CD4+ T cells initiallyundergo cell cycle arrest at G2 caused by a viral accessoryprotein, Vpr, and eventually cytolysis [1,2]. ... PI3K/Akt inhibitors, including clinically available Miltefosine,dramatically reduced HIV-1 production from long-living virus -infected macrophages. These PI3K/Akt inhibitors hyper-sensitize infected ... promising in further developing Aktinhibitors as a novel antiviral therapeutic.Most importantly, we also examined the ability of PI3K/Akt inhibitors to induce cell death specifically in HIV-1infected...
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Báo cáo y học: " The pp24 phosphoprotein of Mason-Pfizer monkey virus contributes to viral genome packaging" potx
... innate ability to assemble intoimmature capsids or procapsids in the cytoplasm, recog-nize and package the viral RNAs and glycoproteins and facilitate budding from the plasma membrane. During viral ... packages significantly lessvRNA into particles lead us to hypothesize that correctGlycoprotein incorporation and Gag processingFigure 4Glycoprotein incorporation and Gag processing. COS-1 cells ... of infected cells at 2, 4, 8, 10, and 12 days post-infectionwere determined by RT assays. While wild-type virus rep-licated in Hos cells, as indicated by the increasingamounts of RT activity...
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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
... Holly JMP: Changes in the local regulation of insulin-like growth factors I and II and insulin-like growth factor-binding proteins in osteoarthritis ofthe canine stifle joint secondary to cruciate ... of insulin-like growth factor-bind-ing protein ligand inhibitors in vitro and in vivo. J Cereb Blood Flow Metab 2003, 23:1160-1167.45. Lowman HB, Chen YM, Skelton NJ, Mortensen DL, Tomlinson ... greatly reduced affinity for IGFBPs)Comparative activity of NBI-31772, a small-molecule inhibitor of the binding of insulin-like growth factor (IGF)-1 to IGF-binding proteins (IGFBPs), in primary...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... J, Yamazaki S, Sakihama T,Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T: Immunologictolerance maintained by CD25+CD4+regulatory T cells: theircommon role in controlling autoimmunity, ... [43,44], and the removal ofCD4+CD25+using depleting antibody leads to a similarautoimmune phenotype seen in mice after thymectomy[45]. Studies of experimental autoimmune encephalo-myelitis ... where they originate, in thethymus or in the periphery.One prevailing model is that a class of regulatory T cellsthat originate in the thymus, are self-reactive and areinvolved in protection...
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Báo cáo y học: " The intracellular detection of MIP-1beta enhances the capacity to detect IFN-gamma mediated HIV-1-specific CD8 T-cell responses in a flow cytometric setting pro" ppsx
... other hand, the introduction of polychromatic flow-cytometry-based assays such as the intracellular cytokine staining (ICS) strongly improved thecapacity to detect several markers on a single ... be applied to any staining combination including IFN-γ and MIP-1β in combination with the appropriate lineage markers. Thus,for investigators with no access to sophisticated flowcytometers, ... of cytokines for this kind of assays.On the other hand, the introduction of new reagents,instruments and software, strongly improved the capacityof flow cytometry based assays such ICS and...
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Báo cáo y học: "Early innate immune events induced by prolonged cold ischemia exacerbate allograft vasculopathy" potx
... neutrophilinfluxGiven their role in immediate innate inflammato ry responses and tissue damage, and our previous evidenceimplicating N∅ as effectors in early AV events, weexamined early N∅ influx in both CI groups. ... we chose were designed to mimic the clinical situation, with 20 min in cold salinebeing the standard cold ischemic time in our laboratory and 60 min in cold saline being considered our upperlimit ... innate and late adaptive rejection responses. Clear evidence liking innate and adaptive immune responses can be invoked to develop a hypoth-esis by which prolonged CI could worsen A V byincreasing...
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Báo cáo y học: "Assessment of immune response to repeat stimulation with BCG vaccine using in vitro PBMC model" pdf
... DickinsonBiosciences) and incubated for 30 minutes at room tem-perature. The cells were again washed and resuspended in 1 ml saline and subjected to flowcytometry. Cells col-lected using flow cytometry on a ... listeriolysin, which improves the capacity to stimulate antimycobacterial T-cell responses [11,12].An interesting complementary approach to improvingBCG immunogenicity is its combination in prime-boostimmunization ... subjected to flow cytometryanalysis to determine CD 4 and CD 8 T cell level/cellcount. Flow cytometry was performed on a fluorescenceactivated cell sorter (FACS-SCAN) instrument (BectonDickinson...
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Báo cáo y học: "Levamizole enhances immune responsiveness to intra-dermal and intra-muscular hepatitis B vaccination in chronic hemodialysis patients" pps
... of vaccination which could be moreeffective than the conventional intramuscular (IM) rout. Itis effective in inducing HBs antibody production byincreasing T and B lymphocyte responsiveness, ... B immunity in hemodialysispatients. vaccine 2002, 20:3230-35.21. Pyone kyi K, May Oo K, Moh Htun M, Win Maw T, Khin Khin A, SanSan O, et al.: Clinical trial of the intradermal administration ... in 1 case, Autosomal dominant polycystic disease in 1 case, Nephrolithiasis in 1 case and obstructive uropathy in 1 case).Publish with BioMed Central and every scientist can read your work free...
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