Báo cáo y học: " Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear impo" doc

... 8:17 http://www.retrovirology.com/content/8/1/17 Page 2 of 13 RESEARC H Open Access Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import Lili ... as a novel cellular cofactor for the H IV-1 regulatory protein Rev. We propose that the intermolecular masking of...

Ngày tải lên: 13/08/2014, 01:20

... angiogenesis by binding to the extracellular matrix [25,26]. The release of FGF by a wide variety of cells, especially in condition s of cel- lular damage, may explain the high levels of systemic FGF in ... the investigation of the local expression bFGF of the eso- phageal biopsies of the subjects. Our data show that FGF, as assessed by IHC of local tissue...

Ngày tải lên: 08/08/2014, 21:20

... antibody levels. Pulmonary involvement was assessed by computed tomography, forced vital capacity, and the ratio of carbon monoxide diffusion capacity to hemoglobin. Systolic pulmonary artery pressure ... endothelial injury. Calcium- channel blockers of the dihydropyridine type have clearly been shown to have an effect on Raynaud's syndrome in SSc and several studies have sugge...

Ngày tải lên: 09/08/2014, 01:23

... regards hypertriglyceridemia and hypofibrinogenemia, neither of which is generally applicable to secondary HPS in adults. In these seven patients, the underlying diseases were systemic lupus erythematosus ... Biosystems), and the data were analyzed by the ABI prism 7700 sequence detection system (PE Applied Biosystems). Briefly, 1/50 amounts of of cDNA derived from 1 µg of total...

Ngày tải lên: 09/08/2014, 06:22

... cells isolated from the IPFP proliferated in culture and reached confluence by day 14. The yield of cells by the end of passage 2 was typically 10 7 cells at confluence from 5 g of IPFP tissue (proliferation ... decreased oxygen tension of (1 to 7%) in vivo [13,14]. In chondrocyte culture systems it has been shown that under hypoxia there is increased synthe- sis of extra...

Ngày tải lên: 09/08/2014, 10:20

... therapy, the date at the end of follow-up or the date the patient died, whichever came first. As patients may often stop treatment during an infection or elective surgery, any gaps in the use of the ... &apos ;the length of time from initiation to discontinuation of therapy' [18]. Patients were censored at the date therapy was stopped, the date the patient was...

Ngày tải lên: 09/08/2014, 14:20

... roles during the initial stages of the cell cycle. In particular, we wished to characterize the participation, if any, of these proteins in the process of entry into the cell cycle of G0, growth ... Stacey D, Kazlauskas A: Regulation of Ras signaling by the cell cycle. Curr Opin Genet Dev 2002, 12:44-46. 40. Takuwa N, Takuwa Y: Regulation of cell cycle molecul...

Ngày tải lên: 09/08/2014, 20:20

... in the design of the manuscript and they revised and critically reviewed the manuscript. All authors read and approved the final manuscript. Competing interests The authors declare that they have ... manifestation of both sys- temic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS). Although typically mild and asympto- matic, complications of Libman-Sacks end...

Ngày tải lên: 10/08/2014, 10:20

... Laboratory, London, revealed the isolate to belong to serotype 4. The patient made an uncomplicated reco very without any specifi c antiviral therapy and was extubated on the fifth day of her admission. ... any accompany- ing images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Abbreviations ALT: alanine aminotransferase; ANCA...

Ngày tải lên: 10/08/2014, 23:21

... non-enhancing lesion in the low- er pole of the left kidney (arrow). This was excised by partial nephre- ctomy and found to be a hybrid oncocytoma, a tumor which is typical of Birt-Hogg-Dubé syndrome. ... case series [5]. Lung cysts are frequently seen in BHDS. A recent study found multiple pulmonary cysts in 89% of CT scans of BHDS patients [6]. Cysts in BHDS are typically dis...

Ngày tải lên: 11/08/2014, 12:20