Báo cáo y học: "Retraction: Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells" potx
Báo cáo y học: "Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals" pps
... observed in many aspects of a biological system, ranging from loss of cell- cycle synchronization in an initially synchronized population of cells to different hair color of genetically identical ... contributions SY, XK, and LDH conceived and designed the experiments, and SY, XK, LDH, PW, WJ and LH analyzed the data. SY, LDH and XK wrote the paper. Acknowledgements We than...
Ngày tải lên: 14/08/2014, 21:20
Báo cáo y học: " CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II" pps
... injury involving the structures of the alveolar wall. The alveolar surface area of the lung is covered with a layer of alveolar epithelial cells type I and type II. Type I cells function as a physical ... recruitment of CCR2 and CXCR3 bear- ing mononuclear leukocytes, by human primary AEC-II and airway epithelial like cell line A549 after exposure of the cells to t...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: " Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells" potx
... purposes) Retrovirology Open Access Research Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T -cell leukemia virus type 1-infected T -cell lines and primary adult T -cell leukemia ... proliferation and survival of ATL cells. Previously we showed that NF-κB pathway is consti- tutively activated in HTLV -1-in...
Ngày tải lên: 13/08/2014, 09:21
Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
... variety of stimuli both in pri- mary cells and in cell lines [9]. In the RA synovium, p38 MAPK is predominantly activated in endothelial cells and in the lining layer [10]. Inhibition of p38 ... induction of MMP9 in monocytes is mainly regu- lated by the ERK1/2 pathway and not the p38 MAPK path- way [27]. p38 MAPK inhibitors have effects on various cell types, thereby po...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
... between cell growth and differentiation and cell survival and cell death [25]. Among them, IL-6 and IL-8 are mainly produced by endothelial cells and are critical players in the initiation phases of ... the entry pathway of non-modified virus is exclusively CAR- dependent. On the other hand, the transduction of HUVECs by AddnIκB-PEG-RGD was significantly inhibited...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways" ppsx
... KT: Human T -cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol Cell Biol 1998, 18:3620-3632. 57. Akagi T, Ono H, Shimotohno K: Expression of cell- cycle ... H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M, Yamamoto N: Rapid tumor formation of human T -cell leuke- mia virus typ...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)" pot
... sig- nificant efficacy and contribute to the observed in vivo effects. We recently elucidated the cellular effects of δ- (3,4-dihydroxy-phenyl)-γ-valerolactone and δ-(3-meth- oxy-4-hydroxy-phenyl)-γ-valerolactone ... δ-(3,4-dihydroxy-phenyl)-γ-valerolactone and δ-(3-methoxy-4-hydroxy-phenyl)-γ-valerolactone exhibited inhibitory activity on LPS-induced secretion of matrix metalloprot...
Ngày tải lên: 11/08/2014, 08:21
Báo cáo y học: "Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines'''' unexpected therapeutic properties" pot
... oxygen species (both directly and via inflammatory cells), excitotoxicity, and expression of the death receptor family members in a vari- ety of cells [10-12]. Many of these activities have been studied ... toxicity of excess lysoPCs cannot be ignored, so there is likely an upper limit of lysoPC dos- ages that will accomplish the inhibition without cytotox- icity. Dose limitat...
Ngày tải lên: 11/08/2014, 08:22
