Báo cáo y học: "Tetherin restricts direct cell-to-cell infection of HIV-1" pot

... surface expression was induced by 100 ng/ml doxycycline and was detected by flow cytometry using a PerCP-labeled secondary antibody directed against a primary anti-tetherin antibody. Data points are derived ... antibodies, and inhibitor s of viral entr y [14,31,33,55]. In our system, the presence of Efavirenz (500 nM) only partially reduced infection of target cells (Supplementary F...

Ngày tải lên: 13/08/2014, 01:20

... therapies. Etiology of systemic lupus erythematosus Genetic analysis of SLE has advanced impressively, reflect- ing the powerful analytic tools created by the Human Genome Project. Importantly, a combination of ... the entirety of the immune system. Some of these may be genetically determined, whereas others arise secondarily in response to events such as infection. Not surprisingl...

Ngày tải lên: 09/08/2014, 11:20

... A, Danoff D, Osterland CK, Yeadon C, Smith CD: A long-term study of hydroxychloroquine withdrawal on exacer- bations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group. ... lymphocyte activation or modifying the capacity of inhibitors of signaling pathways to appropriately function. Analysis of cell surface molecules on lupus cells has led to descriptions of...

Ngày tải lên: 09/08/2014, 14:22

... Rinsho-kenkyu-hi). Author details 1 Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan. 2 Schizophrenia Research Team, Tokyo Institute of Psychiatry, Tokyo, Japan. 3 Faculty of ... Medicine, Tokyo Medical and Dental University, Tokyo, Japan. 4 Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry...

Ngày tải lên: 11/08/2014, 16:22

... optical density (OD) values for all the different allergens and antibody types and isotypes were calculated and the results of ELISA and ImmunoCAPs analyzed by multivariate analysis of variance ... groups of patients with CF and Af- induced allergy and normal controls. The results indicate that no single allergen specificity or antibody isotype spe- cificity can reliably identify ABPA w...

Ngày tải lên: 13/08/2014, 13:22

... pseudoty ped virus stocks containing 50 ng p24. PBLs were analyzed by flow cytometry three days post infection for CD4 and tetherin expression as already described [34]. Similarly, primary macrophage ... 7:1 http://www.retrovirology.com/content/7/1/1 Page 8 of 13 Figure 1 Mutation of S52A impairs Vpu-mediated degradation of CD4 and tetherin.(A) Western blot analysis of Vpu expressio...

Ngày tải lên: 12/08/2014, 23:22

... expression of HIV-1 Gag (p55 and p24), tetherin and GAPDH by immunoblotting. (B) Flow cytometry analysis of surface tetherin expression in infected DCs at 5 dpi. M, Mock infection; WT, wild-type NL(AD8); ... release and is antagonized by HIV-1 Vpu. Nature 2008, 451:425-430. 28. Sato K, Yamamoto SP, Misawa N, Yoshida T, Miyazawa T, Koyanagi Y: Comparative study on the effect of human...

Ngày tải lên: 13/08/2014, 01:20

... micro- biologically documented in 58% of cases; this low percentage may be explained by the frequency of respiratory tract infection in our study (60% of cases), because microorganisms are not usually isolated ... in Physiology and Pathology of the Leu- kocytes Edited by: Braunsteiner H, Zucker-Franklin D. New York: Grune & Stratton Inc; 1962:1-22. 19. Gil H, Magy N, Mauny F, D...

Ngày tải lên: 25/10/2012, 10:35

... Association of Critical- Care Nurses, American College of Chest Physicians, American College of Emergency Physicians, Canadian Critical Care Society, European Society of Clinical Microbiology and Infectious ... day; P = 0.025), longer ICU length of stay (15 versus 8 days; P < 0.0001), and longer hospital length of stay (23 versus 12 days; P = 0.01). Conclusion In our cohort of...

Ngày tải lên: 25/10/2012, 10:35

... initiating treatment with antipsychotics. However, a careful medical history should be taken for symptoms of cardiac pathology, such as recurrent syncope. A family history of early sudden death should ... history of QT prolon- gation, polypharmacy (metabolic inhibitors or other drugs known to affect the QT interval), high doses of antipsychotics, or symptoms possibly related to arrhyt...

Ngày tải lên: 25/10/2012, 10:51