Báo cáo y học: "Hepcidin induces HIV-1 transcription inhibited by ferroportin" pps

... and by inhibiting phosphory- lation of HIV-1 transcriptional activator protein Tat by CDK2 [2]; we previously showed CDK2 to be important for HIV-1 transcription [11]. Our most recent study showed ... understood. We recently showed that HIV-1 transcription was inhibited by iron chelators which A FAC - + - + Hepcidin - - + + Pi y (counts) 6000 8000 10000 P r i mary Monocyte...

Ngày tải lên: 13/08/2014, 01:20

... large scale, but they usually lack the ability to functionally annotate synergistic TFs. Furthermore, methods based on phylogenetically conserved sequences, although they can greatly reduce the false ... E2F1 and YY1 genes, the TFBS pairs are in vastly different locations. We thus hypoth- esize that it is very unlikely that traditional approaches like phylogenetic footprinting could identify...

Ngày tải lên: 14/08/2014, 08:20

... contacts by cyclic AMP. J. Cell. Physiol. 157, 296–306. 10. Han, J.D. & Rubin, C.S. (1996) Regulation of cytoskeleton organization and paxillin dephosphorylation by cAMP. Studies on murine Y1 adrenal ... phosphorylation, as demon- strated by the experiments with BAPTA, which only diminished MLC phosphorylation by about 50%. The enhanced capability of cAMP of inhibiting MLC phos-...

Ngày tải lên: 21/02/2014, 01:21

... purification A. thaliana seeds, ecotype Columbia were kindly provided by F. Floto, and cell suspension culture by O. Mattsson, both at the Department of Plant Physiology, University of Copenhagen. Plants ... therefore analyzed by TARGETP , which distinguishes between chloro- plast, mitochondrial, secretory pathway and ÔotherÕ locali- zations [26]. All AtPs were predicted for the secretor...

Ngày tải lên: 21/02/2014, 01:21

... were harvested and Sty1p was purified by affinity chroma- tography. Activated Sty1p was detected by inmunoblotting with anti(phospho p38) antibodies. Total Sty1p was determined by inmu- noblotting ... Aliquots were harvested and Sty1p was purified by affinity chromatography. Activated Sty1p was detected by inmunoblotting with anti-(phospho p38) antibodies and anti-Ha antibody inmunoblotti...

Ngày tải lên: 08/03/2014, 09:20

... p300/CBP by CARM1; STAT1 by PRMT1), thereby regulating the transcriptional activity of the target proteins [103,104]. However, the role of factor methylation in NR-dependent transcription has not yet been ... NRs [61,106,107]. Interestingly, the repression of NR activity by histone H1 can be relieved by the ligand- dependent phosphorylation of H1 by cdk2 (and possibly other kinase...

Ngày tải lên: 31/03/2014, 21:21

... an organism’s capacity to generate heritable phenotypic variation, and so increase overall ‘evolvability’. e fluidity of eukaryotic transcriptional regulatory regions may therefore enable the ... mutations (and not by insertions or deletions), suggesting that changes in TF occupancy are largely caused by the steady accumulation of small sequence changes [3]. Interestingly, a substa...

Ngày tải lên: 09/08/2014, 20:22

... produced by M. arthritidis, activates T cells by forming a complex between the major histocompatability complex II on antigen presenting cells and the T cell receptor on CD4+ T lymphocytes. The ... of human inflammatory arthritis for more than 30 years. Much of the disease phenotype and out- comes are influenced by the M. arthritidis mitogen (MAM) superantigen produced by the organism...

Ngày tải lên: 11/08/2014, 08:22

... co-infected by wild-type and vaccine strains. In summary, the multiplex RT-nPCR developed in this study is a highly specific and sensitive assay for the rapid detection and differentiation of wild- type ... cuishangjin@yahoo.cn 1 State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China † Contributed eq...

Ngày tải lên: 12/08/2014, 04:20

... accessibility and immune function, we hypothe- sized that hepcidin is expressed by airway epithelial cells. We further postulated that hepcidin expression is coordinated by pro-inflammatory cytokines ... direct antimicrobial activ ity by lysis of the mycobacterium [10]. This suggests that cellular localization of hepcidin in response to invading pathogens, which is not well assessed by...

Ngày tải lên: 12/08/2014, 13:22