Báo cáo y học: " Revisiting HIV-1 uncoating" doc

... and reliable assays for uncoating. No assay may be relied upon solely when interpreting uncoating events. Timely uncoating is key for HIV-1 reverse transcription, nuclear import and infectivity Lessons ... (18-24°) may vary and l ead to capsids with appar ent heterogeneity of shape (bullet shape, cylindrical forms). The intrinsic properties of the HIV-1 capsid, such as its poor stability...

Ngày tải lên: 13/08/2014, 01:20

... M, Coryell W, Pfohl B, Stangl D: The Reliability of the Family History Method for Psychiatric Diagnosis. Archives of General Psychiatry 1988, 45:320-322. 29. Rahe R: Stress and Psychiatry. In ... SJ, Akil H, Young E: Hypothalamic-pituitary-adrenal axis peptides in affective disease: focus on the ACTH/β- endorphin system. In Handbook of Clinical Psychoneuroendocrinology Edited by: Nemeroff ......

Ngày tải lên: 08/08/2014, 23:21

... provide evidence that a physical shock can directly lead to MSU crystal nucleation, the authors hypothesised that local trauma indirectly enhances crystal nucleation by lowering synovial pH [22]. Hence, ... J: Gouty arthritis in nodal osteoarthritis. J Rheumatol 1996, 23:684-689. 31. Kawenoki-Minc E, Eyman E, Leo W, Werynska-Przybylska J: Osteoarthrosis and spondylosis in gouty patients. Anal...

Ngày tải lên: 10/08/2014, 21:24

... NR W121G 1.1 6 NR W121F 1.5 31 0.05 W12 1Y 1.3 22 0.03 Y1 22Q 2.2 333 0.4 Y1 22F 1.2 660 4.6 W121Q /Y1 22Q 1.7 9 NR W12 1Y/ Y122W 1.2 7 0.13 W121F /Y1 22F 1.5 7 NR Y2 26F 1.3 626 2.4 2982 V. Drosou et al.(Eur. ... i.e. its (already low) residual electron transfer activity is not maintained by the neighbouring tyrosine, while the W121F /Y1 22F mutant activity may be viewed as a commitment...

Ngày tải lên: 22/02/2014, 07:20

... except ipsilateral axillary lymph nodes (T2-3, N0-1, M0), were eligible for the study provided that they had not pre- viously received any type of systemic or local primary treatment for breast ... ran- domly allocated to receive four 3-weekly cycles of preoperative XT (capecitabine 1000 mg/m 2 BID on days 1-14 and docetaxel 75 mg/m 2 on day 1) or AC (doxorubicin 60 mg/m 2 and cyclop...

Ngày tải lên: 08/08/2014, 17:20

... and phosphorylation of receptor cytoplasmic domain tyrosine residues. STATs dock on these phosphotyrosine motifs by means of their Src homology 2 (SH2) domains. STATs are then phosphorylated on ... dephosphorylated in the cytoplasm, possibly by SHP-2 [60]. It seems that there is substrate specificity in the dephosphorylation of STATs by PTPs, and it is not clear how this specificity is achiev...

Ngày tải lên: 09/08/2014, 01:23

... people on my staff.” Sadly, for the United States and for the world, he was not being ironic - he actually believed what he said. The notion that people close to the king typically try to remain ... http://genomebiology.com/2009/10/11/113 Petsko: Genome Biology 2009, 10:113 Former US President George W Bush was not a man given to irony. Yet, asked where he got his information, he replied,...

Ngày tải lên: 09/08/2014, 20:20

... actually caused by, say, sunspots or something similar, reduction of emissions may not do so much. But everyone agrees that they will do something, and my point is that something simply has ... begin to study such solutions to determine the extent of our ignorance and the possibility that we might someday be able to employ them, I wouldn’t say no. So, the next time you find yourself in ....

Ngày tải lên: 09/08/2014, 20:21

... more generally, gene regulation. Unconventional interactions of the secondary type e late Ed Lewis famously said ‘Progress will still need to be driven by the logic of genetics and by further ... genes, and differed in physiologically relevant ways in different species. Continuing the theme of evolution and binding localization, Mike Snyder (Stanford University, Stanford, USA) presented ....

Ngày tải lên: 09/08/2014, 20:21

... trials [13]. A 14-day randomized, controlled safety and acceptability trial of Acidform™ compared with KY Jelly demonstrated that Acidform™ is more likely to cause genital irritation than KY Jelly (OR 2.6, ... Arts, Moore Dawn, Pinter Abraham, Veazey Ronald: Natural HIV-1 polymorphism alter sensitivity to the various entry inhibitors but less so to PSC-RANTES and yet there is still evidence...

Ngày tải lên: 10/08/2014, 05:20