Báo cáo y học: "Evolution of the HIV-1 nef gene in HLA-B*57 Positive Elite Suppressors" pdf

... complex, the tricarboxylic acid cycle, and the glyoxylate cycle by examining t he individual phylogenies of the 21 s ubunits comprising the 14 enzymes of these pathways as they occur in eukaryotes, ... out of style (see [26]). Sixty-four years later, gene- for -gene phylogenetic analysis can provide insights into the origin of its individual enzymes. However, the study...

Ngày tải lên: 22/02/2014, 04:20

... gag and nef in HLA-B*57 positive ES. We previously showed evolution in the gag gene of ES which surprisingly was mostly due to synonymous mutations rather than non-synonymous mutation in targeted CTL ... muta- tions in Nef. However, in all four patients, we saw very few non-synonymous mutations and a comparable fre- quency of synonymous mutations in both genes. This...

Ngày tải lên: 13/08/2014, 01:20

... appears to be highly glycosylated in naturally infected SMs. Presumably, continually evolving antibody responses in these natural hosts maintain a highly glyco- sylated surface protein, albeit without ... extraordinar- ily high intra-host SIVsm env V1V2 diversity in naturally infected SMs, maintained by its high replication rate and positive selection most likely mediated by antibody...

Ngày tải lên: 13/08/2014, 09:21

... posi- tion in the interior of the gp41 core, but the orientation of their side chains differs (fig. 6). The side chain of residue 593 (cyan in fig. 6) points towards the interior of the loop, thereby ... reversions in structure model of the HIV-1 gp41 ectodomain [18]Figure 6 Modeling of the SOS reversions in structure model of the HIV-1 gp41 ectodom...

Ngày tải lên: 13/08/2014, 13:20

... supported by the majority of genes. Finally, p values were corrected for multiple hypothe- sis testing using the Benjamini and Yekutieli method [75]. The effect of lineages, and genes' TIGR main ... these results, and the ambiguity of defining which genes had the same history, we analyzed each gene with its own gene tree in the subsequent positive selection anal...

Ngày tải lên: 14/08/2014, 07:21

... state the activities of numerous interacting genes are altered which may influence the effect of PPARδ on metabolism. In our data and in the study by Skogsberg et al., the effect of the C ... by silver staining on polyacrylamid gel. Statistical Analysis Allele frequencies were determined by gene counting and compared using the א² test. The data was analysed u...

Ngày tải lên: 31/10/2012, 17:03

... sequenced the gene of Mn-LOX of G. graminis and the corresponding cDNA. Our main finding is that Mn-LOX belongs to the LOX gene family with a unique difference in one of the conserved regions. The deduced ... deter- mine the impact of deleting one or two amino acids in a helix 9 on the metal center and on the catalytic properties. The corresponding studies wit...

Ngày tải lên: 18/03/2014, 01:20

... stop taking aspirin and all cytokine inhibitors 10 to 14 days prior to surgery. Histology of synovial biopsies and levels of cytokines Haematoxylin and eosin histology was performed on 26 of the OA ... Representative micrographs of this grading system are presented in Figure 1. Quantification of inflammatory cytokines in synovial fluid Cytokine profiles in synovial fluid we...

Ngày tải lên: 09/08/2014, 10:23

... the TSP-2 gene with respect to the morphology and cellularity of the annulus, the presence of vascular beds within the disc, and vascularity of the soft tissue margin of the disc that serves to supply ... vascular ingrowth into discs of the TSP-2-null mice. Conclusion These data confirm a role for TSP-2 in the morphology of the disc and suggest the presen...

Ngày tải lên: 09/08/2014, 10:23

... for intracellular immunization [2]. However, the delivery of such genes using a packaging system based on HIV-1 is hampered by the inhibitory effect of the anti -HIV-1 genes, such as Rev M10, on the ... containing construct. To the best of our knowledge, our study is the first to evaluate SIV RRE in the context of an HIV-1- based gene delivery system. The abili...

Ngày tải lên: 10/08/2014, 05:21