Báo cáo y học: "A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins" ppsx

... structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins Natsuko Inagaki 1 , Hiroaki Takeuchi 1 , Masaru Yokoyama 2 , ... Here, by comparing two pathogenic SIV strains, SIVmac239 and SIVsmE543-3, we found critical amino acid residues for functional interaction between the...

Ngày tải lên: 13/08/2014, 01:20

... phenotypic values for traits y and z can be structured in terms of φ y , φ z , ψ y , ψ z and Σ ε (t) by a bivariate SAD(1) model [15,16]. Also, the closed forms for the determinant and inverse ... for circadian rhythms. In a mapping study of 196 F 2 hybrid mice, Shimomura et al. [24] detected 14 interacting QTL that contribute to the variation of rhyth- mic behavior...

Ngày tải lên: 13/08/2014, 16:21

... fatigue, hyperexcitability, insomnia, and increased appetite for approximately 20 days. Her HIV-1 infection was treated daily with the fixed dose combination of 200 mg emtricitabine and 300 mg tenofovir ... Cushing's syndrome and secondary adrenal insuffi- ciency after a single intra-articular administration of triamcinolone acetonide in HIV-infected patients treated with riton...

Ngày tải lên: 10/08/2014, 05:21

... initial rolling and tethering interactions between circulat- ing granulocytes, monocytes, and lymphocytes to endothelial cells at sites of tissue injury [138,142]. P-selectin glycopro- tein ligand-1 ... tissue injury. Functional interrelationships between clotting and the innate immune response The close ancestral and functional linkage between clotting and inflammation is...

Ngày tải lên: 12/08/2014, 19:21

... (2001) The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site. J. ... of the cofilin–G-actin interaction We then tested for a pH dependence in the interaction of cofilin with G-actin by two independent methods. G-actin was labeled with RITC and increa...

Ngày tải lên: 31/03/2014, 09:20

... in part mediated by a portion of the N-terminal region in vicinity of the a-crystallin domain. To ensure that efficient dimerization requires solely a-crystallin domain and N-terminal region and ... with aA-crystallin and Hsp27 [45] indicate that the dimeric building block of many a-Hsp proteins is formed by interacting bstrands in the a-crystallin domain. Although this may als...

Ngày tải lên: 31/03/2014, 21:21

... significantly inhibited IP-10 induction. These results suggest that IP-10 expression within inflamed joints appears to be regulated not only by inflammatory cytokines but also by the physical interaction ... contami- nating lymphocytes as a major source of IP-10 in the FLS–monocyte interactions. We examined the effect of mononuclear lymphocytes on IP-10 secretion in FLS lym- phocytes. S...

Ngày tải lên: 09/08/2014, 01:21

... proinflammatory cytokines TNF-α and IL-6 was increased. These findings suggest that impairment of immune tolerance by increased T- cell reactivity does not lead to enhanced susceptibility to CIA and point ... disease by destroying target tissues through induction of apoptosis of chondrocytes [33]. Alternatively, Fas could contribute to synovial hyperplasia by inducing proliferation of Fas...

Ngày tải lên: 09/08/2014, 01:23

... [http://genome.ucsc.edu/ ] 10. Online Mendelian Inheritance in Man, OMIM™. McKusick-Nath- ans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Infor- mation, ... QTLs in rat were obtained from the RatMap database [7]. These data were originally collected from experimentally induced inflammatory arthritis in rat strains...

Ngày tải lên: 09/08/2014, 06:22

... Turpaz Y: Ploidy status and copy number aberrations in primary glioblastomas defined by integrated analysis of allelic ratios, signal ratios and loss of heterozygosity using 500K SNP Mapping Arrays. ... providing the cell line data for HL-60 and HT-29. CY is funded by a UK Medical Research Council Specialist Training Fellowship in Biomedical Informatics (Reference No. G0701810)...

Ngày tải lên: 09/08/2014, 22:23