... structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteinsNatsuko Inagaki1, Hiroaki Takeuchi1, Masaru Yokoyama2, ... Here, bycomparing two pathogenic SIV strains, SIVmac239 and SIVsmE543-3, we found critical amino acid residues for functional interaction between the N-terminal and the C-terminal domains in CA.Results: ... present in vitro and in vivo evidence implicating the interaction between Gag residues205 in CA NTD and 340 in CA CTD in SIV replication. Thus, this study indicates a structural constraint for functional interaction...