Báo cáo y học: " In silico modeling indicates the developmen

Báo cáo y học: " In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy" docx

... 14 RESEARC H Open Access In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy Tanya Lynn Applegate 1,2* , Donald ... directly to the development of an entire CD4+ T cell population containing the therapeutic gene( s). It will likely be contained within a minor...

Ngày tải lên : 13/08/2014, 01:20

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Báo cáo y học: "In silico experimentation with a model of hepatic mitochondrial folate metabolism" pps

... by the mitochondria is cut in half. Thus the elimination of mSHMT and external glycine together is clearly very detrimental to the cell. Interestingly, the net flux of glycine remains from cytosol to ... being supplied by the mitochondria so the rates of thymidylate synthesis and purine synthesis are greatly reduced. The rate of the cytosolic SHMT increases appro...

Ngày tải lên : 13/08/2014, 16:21

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Báo cáo y học: " In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate" pdf

... [10,11]. IN inhibitors currently in clinical trials belong to the INSTI group. Chemically, they display a β-hydroxy carbonyl (Fig. 2), thought to bind the (possibly) two metal ions coordinating the ... transfer inhibitors (INSTIs) maps to the putative acceptor DNA binding site Previous studies showing a dependence of the inhibitory activity of INSTIs from the concen...

Ngày tải lên : 13/08/2014, 09:20

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Báo cáo y học: "In silico evidence for the species-specific conservation of mosquito retroposons: implications as a molecular biomarker" ppt

... Structurally, introns are a six-moiety complex. Depending on the function of the protein encoded within the IV moiety, the highly mobile class of group II introns or retroposons is sub-divided into two: ... to human spliceosomal elements To define the exact relationship of the hits obtained by querying the C. pipien and An. sinensis retroposons against the human gen...

Ngày tải lên : 13/08/2014, 16:20

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Báo cáo y học: " In silico analysis of chimeric espA, eae and tir fragments of Escherichia coli O157:H7 for oral immunogenic applications" doc

... prospec- tive engineering and re-engineering of protein therapeu- tics, reducing the risk of undesired immunogenecity and improving the likelihood of success in clinical use. Finally, the conclusions ... SacI) were introduced at the ends of the syn- thetic gene for future cloning into plant expression vec- tors. Graphical depiction of the predicted minimum free energ...

Ngày tải lên : 13/08/2014, 16:20

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Báo cáo y học: "Smoking and nicotine exposure delay development of collagen-induced arthritis in mice" pptx

... time-dependent immune-modulating effect of the sympa- thetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. ... (Figure 2d). Ameliorating effect of cigarette smoke exposure on antibody production Taking into consideration the role of antibody production in the pathophysiology...

Ngày tải lên : 09/08/2014, 14:21

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Báo cáo y học: " Protocol for a randomised controlled trial of risk screening and early intervention comparing childand family-focused cognitive-behavioural therapy for PTSD in children following accidental injury" pot

... trial examining the efficacy of a tra uma focused, C BT early intervention for the treatment of PTSD in children following exposure to accidental injury. Further, a controlled trial examining the ... improvements in psycho logical symptoms as well as health-related quality of life. Further, the design of the study will allow for an examination of improvements and m...

Ngày tải lên : 11/08/2014, 16:22

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Báo cáo y học: " Protocol for a randomised controlled trial of risk screening and early intervention comparing childand family-focused cognitive-behavioural therapy for PTSD in children following accidental injury" pptx

... controlled trial of risk screening and early intervention comparing child- and family-focused cognitive-behavioural therapy for PTSD in children following accidental injury. BMC Psychiatry 2011 11:15. Submit ... CH: Factors affecting the diagnosis and prediction of PTSD symptomatology in children and adolescents. American Journal of Psychiatry 2006, 163:644-651. 3. Scheeringa MS...

Ngày tải lên : 11/08/2014, 16:23

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Báo cáo y học: " In vitro bioassay as a predictor of in vivo response" pdf

... on [2]. But engineered modifications of hormones, growth factors or their ana- logs are likely to differ from the native analogues in their affinity for binding proteins. In view of this, an important practical ... define β (degree of conjugation) as the proportion of BAS that is free of binding proteins and is available to interact with cognate receptors. The larger i...

Ngày tải lên : 13/08/2014, 22:22

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Báo cáo y học: "Predictive network modeling of the highresolution dynamic plant transcriptome in response to nitrate" pps

... 4b). Interestingly, SPL9 seems to have an effect on the vast majority of the genes in the reg ula- tory network that we have tested (Additional file 5). The diversity of the misregulation of gene ... processes dynamical models with nonlinear dynamics to infer the profile of a single transcription factor (the tumor suppressor p53) and explained the activity of...

Ngày tải lên : 09/08/2014, 22:23

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