Báo cáo y học: "HIV-1 subtype distribution in the Gambia and the significant presence of CRF49 cpx, a novel circulating recombinant form" pdf
Báo cáo y học: "HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form" pdf
... data and participated in writing the manuscript, CO participated in designing the sequencingstrategy and methods and assisted in the initial analysis of the sequences,BF helped interpret the ... each non -recombinant fragment. Recombinant map of CRF49_ cpx (top) drawn using the Recombinant HIV-1 Drawing Tool at LAHDB and depicting HXB2 numbering at breakpoints estimated viabootscan analysis ... C2-V3 analysis,therefore the high frequency of CRF49_ cpx isolatesobserved in the Gambia may not extend to neighboringSenegal. The geographical and subtype information in the LAHDB are gathered...
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Báo cáo y học: " Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination" pps
... mainlybecause of the complex anatomy of the central nervoussystem and the unavailability of physiological para-meters [54, 55]. Whereas the mechanisms involved in drug disposition into brain are ... (NCYP450 in nmol): amount of cytochromeP450; (Papp, ab in dm/min): apical to basolateralapparent permeability through the Caco-2 monolayer;(Papp, ba in dm/min): basolateral to apical apparentpermeability ... Pharmacol Exp Ther 1990, 253:884–891.47. Makhey VD, Guo A, Norris DA, Hu P, Yan J and Sinko PJ:Characterization of the regional intestinal kinetics of drugefflux in rat and human intestine and...
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Báo cáo y học: "Distinct synovial immunopathology in Behçet disease and psoriatic arthritis" pot
... 130:46-54.31. Yasuoka H, Okazaki Y, Kawakami Y, Hirakata M, Inoko H, Ikeda Y, Kuwana M: Autoreactive CD8+ cytotoxic T lymphocytes tomajor histocompatibility complex class I chain-related gene A in patients ... vessels as wellas expression of perforin and granzyme. The stained slides wereevaluated by digital image analysis.Results The global degree of synovial inflammation was similar in the two types of ... samples are summarized in Table 1. The number of CD68+ macrophages, which reflects global synovial inflamma-tion [16], was similar in the intimal lining layer as well as the synovial sublining of...
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Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx
... whereas the LEW. 1A rat, carrying the sameMHC alleles as the DA rat, was a high responder [3]. In the murine models, preliminary data indicate that similarstrains, carrying the Q haplotype, ... that have not yet been investigated in RPpatients. Adjuvants and oils can induce arthritis in many ratstrains [33–36] and auricular chondritis in Wistar rats[21]. Finally, in FH and Wistar rats, ... presenting a fatal tracheomalacia, indicat-ing CIX and CXI rather than CII as being involved in chon-dritis of the respiratory tract [17]. The humoral response has been the main target for inves-tigation...
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Báo cáo y học: "Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow" doc
... composed of at least three main and distinct signalling pathways: the extracellular signal-regulated protein kinases, the c-Junamino-terminal kinases or stress-activated protein kinases, and the ... among the inflammatory factors the proinflammatory cytokine IL-1β plays a central role in OApathophysiology. Factors that regulate its synthesis and/ oractivity are therefore favoured targets. Other ... mediates mostly cartilage aggrecan loss.Metalloproteases In human OA cartilage, the most prominent MMPs arecollagenases, stromelysin and gelatinases. Inhibition of the synthesis/activity of these...
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Báo cáo y học: "Progesterone - new therapy in mild carpal tunnel syndrome? Study design of a randomized clinical trial for local therapy" pptx
... in the hand distribution of the median nerve, more oftenoccurring during night or in early morning waking up the patients. There may be also sensory loss and hand weak-ness and clumsiness causing ... Neurophysiology Clinic Section, University of Siena, Siena, ItalyFull list of author information is available at the end of the articleMilani et al. Journal of Brachial Plexus and Peripheral Nerve Injury ... and may promote neuroregeneration by sev-eral different actions by reducing inflammation, swelling and apoptosis, thereby increasing the survival of neurons, and by promoting the formation of...
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Báo cáo y học: " Assessing cognitive insight in nonpsychiatric individuals and outpatients with schizophrenia in Taiwan: an investigation using the Beck Cognitive Insight Scale" ppsx
... reliability, correlation analyses, and discriminative validity.Results: The BCIS showed adequate internal consistency and stability over time. Exploratory and confirmatoryfactor analyses on the ... study. YCK analyzed the data further and wrote the finalmanuscript. YPL helped to draft and revised the manuscript. All authors read and approved the paper.Competing interests The authors declare ... Schizophrenia: a preliminary study. Journal of Neuropsychiatry & ClinicalNeuroscience 2001, 13:255-277.12. Sapara A, Cooke MA, Fannon D, Francis A, Buchanan RW, Anilkumar APP,Barkataki I, Aasen...
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Báo cáo y học: " Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery" pps
... a sham-operated group (n = 5). PA vasoreactivity was studied and eNOS assayed. EC apoptosis wasassessed by TUNEL in the proximal and distal PA and by caspase-3 activity assay in the proximalPA. ... istriggered and modulated by two pathways. The intrinsicpathway involves the mitochondria and is activated byreactive oxygen species; whereas the extrinsic pathway isactivated when ligands bind to their ... organs, such as the heart and kidney [20,21]. Cas-pase inhibitors are now available commercially and theirpotential benefits in transplant patients are being evalu-ated in clinical trials.In...
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Báo cáo y học: "Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling" pptx
... alters breathing patterns, and changes in the timing of early and late expirations (Pause) and in Penh are the results of alterations in the timing of breathing, as well as the prolongation of ... function,increases AHR, and induces airway inflammation in dogs[3], guinea pigs [4], and humans [5-7]. Chronic airwayinflammation is associated with airway remodeling thatincludes airway wall thickening ... vascu-lar smooth muscle cell proliferation, hyperplasia, and hypertrophy; and myofibroblast and goblet cell hypertro-phy [8-11]. Airway wall thickening and airway reactivitywere inversely associated...
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Báo cáo y học: "Epidermal wound healing in severe sepsis and septic shock in humans" pptx
... statistical analysis. VK and TIA-Khelped draft the manuscript and helped conceive the study and participated in its design and coordination. JJL and AOparticipated in the design of the study. JS ... than in the controls [36,37]. Early sepsisis characterised by hyper-inflammation and excess of pro-inflammatory mediators such as tumour necrosis factor-alpha and interleukin-1 and interleukin-6 ... possible thatthese mediators cause an increase in local inflammation, aswell. Nitric oxide (NO) is a mediator of early wound healing and inflammation [35]. The levels of NO are increased in sepsis[39,40]....
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