Báo cáo y học: "Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5a-mediated restriction" docx

... H, Nakayama EE, Yokoyama M, Sato H, Levy JA, Shioda T: A single amino acid of the human immunodeficiency virus type 2 capsid affects its replication in the presence of cynomolgus monkey and human TRIM5alphas. ... restriction factors in monkey cells are specified by distinct regions of the human immunodeficiency virus type 1 capsid. J Virol 2004, 78:5423-5437. 63...

Ngày tải lên: 13/08/2014, 01:20

... results further suggest that early dimerization of the PR and RT domains may serve as a regulatory element to influence the kinetics of processing within the Pol domain. Findings The retroviral ... sequence to the viral Gag- Pro-Pol polyprotein precursor [23,27] (Fig. 1A). Intrinsic protease activity was inactivated by a D25A substitution of the catalytic aspartate of...

Ngày tải lên: 13/08/2014, 09:21

... patients using the RPAS and the AIMS, the second using the PANSS and the EPSE and the third using the BARS. Information from the patient's his- tory, concerning social-demographic and clinical ... independent to depression, to general psychopathology symptoms or motor side-effects induced by antipsychotic agents. Regarding the relationship of physical anhedonia...

Ngày tải lên: 08/08/2014, 21:20

... (villages of fleeing slaves, or cimarrones) in the northern coast of Colombia, b eginning in the fif- teenth century. Much later, the term palenque became synonymous with freedom. From the many palenques ... heads of family were inter- viewed in 8 small towns of the northern department of Bolívar. Many of the interviews were accompanied by supplemental informat...

Ngày tải lên: 10/08/2014, 09:22

... termination and increased mRNA stabi- lity by RNA-binding proteins are involved in the regu- lation of gene expression in eukaryotes and their viruses [135,136]. A thorough investigation of these processes ... Thus, further work is needed to clarify the role of the of AsiA C-terminal region. Finally, very recent work has shown that the inability of T4 motA mutants to...

Ngày tải lên: 12/08/2014, 02:20

... [9,10]. In view of the pivotal nat- ure of these studies, it is important to understand the nature of these improvements and factors that may influence them. We have used data from the TORCH trial to ... particu- larly the Symptoms domain, which may continue for ove r 3 months [14 ]. In TORCH, patients were excluded only if they had an exacerbation requiring treatment...

Ngày tải lên: 12/08/2014, 13:22

... correction in HYPHY [14]. In the latter case, we took recombination into account by first detecting recombination breakpoints with GARD [15], and then estimating the d N /d S ratios independently for ... that the rate of virus evolution is greater in this group than in other volunteers. Differences in immune response to HIV-1 infection have been pointed out by the rgp...

Ngày tải lên: 12/08/2014, 23:21

... by ana- lysts to suit the particularities of their own setting. In adapting these tools, analysts have to assess if the assumptions outlined in this paper are appropriate for their own setting. ... programme covering 95% of the population. However, as shown in Table 2, the domestic margin is a minor cost compared to the cost of initially transporting a good to t...

Ngày tải lên: 13/08/2014, 13:20

... germination (the following May). After one month, all these five saponins were detected in the root. Then, with the growth of seedling, the sapo- nin contents increased rapidly in the root. The accumu- lation ... [11]. Allthesefindingssuggestthatsaponinsmaynotserve as the nutrient storage in the seed. The protective func- tions of saponins in other plants are repo...

Ngày tải lên: 13/08/2014, 14:20

... admitting very elderly patients to the ICU. Despite the apparent increase in demand for, and provision of critical care services to, the elderly, there are few data on the outcomes from these ... likely to be discharged to a rehabilitation or long-term care facility, as opposed to living independently in the community. Several factors increased the odds of death...

Ngày tải lên: 13/08/2014, 16:20