Báo cáo y học: "A role for adrenomedullin in the pathogenesis of alveolar edema" pdf

Ngày tải lên: 13/08/2014, 01:20

... critical in the regulation of p53. Intriguingly, in the case of Numb it seems unclear whether it is the interaction with MDM2 or the interaction with p53 that is key to protecting p53 from ubiquitination ... stage of binding that is critical for ubiquitination of p53, and it is possible, therefore, that Numb inhibits this second binding step without perturbing the init...

Ngày tải lên: 14/08/2014, 08:21

... copy of the written consent is available for review by the Editor -in- Chief of this journal. Acknowledgements We sincerely appreciate the superb assistance of Cheltus Cheyuo MD of the Feinstein Institute ... highly successful in treati ng eyelid burn injuries, especially flame burn injuries of the eyelid. Introduction Eyelid involvement is common in facial burns. Tr...

Ngày tải lên: 10/08/2014, 23:22

... required for efficient integration or PIR. On the other hand, some reduce the efficiency of integration. Finally, some are involved in integration site selection. We have studied the role of the histone ... involved in the life-cycle of HIV-1- based vectors. Our finding also supports the hypothesis that cellular DSB repai r proteins are invo lved in PIR. At the s...

Ngày tải lên: 12/08/2014, 01:21

... articular cartilage is maintained by the cartilage cells, chondrocytes. Changes in chondrocytes, leading to the inability of these cells to maintain the homeostasis of articular cartilage, can ... collagen [15].  is cytokine causes destruction of cartilage by increasing enzyme activity while decreasing the synthesis of enzyme inhibi- tors [16]. IL-1 can stimulate chondr...

Ngày tải lên: 12/08/2014, 11:22

... chemokine and its recep- tor in the pathogenesis of ILD, as suggested by mouse models. In these models, the relevance of the MCP-1/ CCR2 interaction was mainly addressed with respect to pulmonary ... levels of MCP-1 were closely related to the effectiveness of corticos- teroid therapy. Given the assumption that MCP-1 and CCR2 are important players in the pathophysi...

Ngày tải lên: 12/08/2014, 18:22

... mortality rate compared with controls, but the difference was not statistically significant (27% versus 43%). The originality of this study lies in the ‘early antibiotic treatment’ arm, in which the ... before, and similar findings were reported by Cinar and colleagues [4]. But in a study by Schwarz and colleagues [5], there was no difference between prophylactic and early the...

Ngày tải lên: 13/08/2014, 11:23

... study will further inform the generalizability of our findings. Competing interests The authors declare they have no competing interests. Authors' contributions SYSW conceived of the ... participated in the drafting of the protocol for the intervention. WWSL participated in the coordination, as well as the revision of the manuscript. She also par...

Ngày tải lên: 11/08/2014, 16:21

... antigen by the T cell receptor (TCR) results in the strengthening of the Tcell- APC interaction, which is primarily mediated by an increase in the affi nity of integrins for their corresponding ... number of presynaptic and postsynaptic specializations in the brain, indicating that Agrin has a role, at least in part, in maintaining synaptic structure in thi...

Ngày tải lên: 12/08/2014, 12:20

... of these pairs was then used for breeding, mainly to preserve the species for the killifish community [11]. Offspring of these fish have since been maintained by dedicated hobbyists and in the ... com- paratively long life span of vertebrate model organisms poses a difficulty for testing of findings initially obtained in inverte- brates - for example, a life expectan...

Ngày tải lên: 14/08/2014, 21:20