Báo cáo y học: "Activated protein C in sepsis: down but not out, yet" pdf

Ngày tải lên: 13/08/2014, 01:20

... In the present issue of Critical Care, Pettila and colleagues report the fi rst single-centred pilot randomized controlled trial of activated protein C (APC) in alcohol- induced acute pancreatitis ... http://ccforum.com/content/14/4/R139/abstract COMMENTARY *Correspondence: Duncan.Wyncoll@gstt.nhs.uk Guy’s and St Thomas’ NHS Foundation Trust, London SE1 7EH, UK Shankar-Hari and Wynco...

Ngày tải lên: 13/08/2014, 21:21

... Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care ... ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655. 20. Dellinger RP, Carlet JM, Masur H, Gerlach H, Cala...

Ngày tải lên: 14/08/2014, 07:21

... Chang FY, Ben RJ, Yin HC, Ni YH, Tsai JW, Cheng SH, Wang JT, Liu YC, Cheng YW, Chen ST, Fung CP, Chuang YC, Cheng HP, Lu DC, Liu CJ, Huang IW, Hung CL, Hsiao CF, Ho M: Etiology of community ... ECM, Brandjes DPM, Büller HR, Levi M: Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasm...

Ngày tải lên: 13/08/2014, 20:21

... arguably only after RCTs have confirmed medication efficacy). Studies like the present one are therefore important. Dhainaut and colleagues prospectively collected clinical outcome data in patients ... first economic evaluation of recombinant human activated protein C (APC) in patients with severe sepsis performed using “real world” effectiveness data [1]. Economic evaluations in cr...

Ngày tải lên: 13/08/2014, 08:20

... throm- bin activatable fi brinolysis inhibitor. Activated throm bin activatable fi brinolysis inhibitor inhibits the chemotactic factors C3 a and C5 a, which could be important for prevention of in ... to systemic in ammation and intense neutrophil in ux into the lung. Activated protein C attenuates coagulation activation and restores  brinolytic capacity but has little e ect...

Ngày tải lên: 13/08/2014, 20:22

... vasodilator capacity by Escherichia coli endotox- emia. Circ Res 1993, 72:539-551. 5. Reidy MA, Bowyer DE: Scanning electron microscopy: mor- phology of aortic endothelium following injury by endotoxin and ... expression or ACh receptor-NOS coupling. This could be caused by the lack of binding of aPC to EPCR, explaining its lack of effect on the NF- κB pathway, the inflammatory process, monoc...

Ngày tải lên: 12/08/2014, 23:22

... microcirculation, particularly of the intestine, in septic conditions [4,6,8,9]. There is an increasing body of evidence that activated protein C (APC) exerts beneficial effects in the microcirculation. ... improved intestinal microcirculation by protecting functional capillary density as a measure of microvascular perfusion and exerted anti-inflammatory effects by reducing leucocyte...

Ngày tải lên: 13/08/2014, 03:20

... frequently seen in the context of severe septic shock, in particular in patients with meningococcemia, PF also occurs in the rare sce- nario of homozygous or double heterozygous protein C (PC) deficiency ... KF, Hazelzet JA: Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized...

Ngày tải lên: 13/08/2014, 21:21

... wild-type background does not result in a readily d etectable phenotype. Strains lacking Ppz1 are prone to cell lysis under certain circum- stances, such as the presence of low c oncentrations of caffeine ... its amount was significantly r educed in ppg1 cells, in agreement with the low glycogen levels. Interestingly, a recent large- scale yeast two -hybrid screen for protein protei...

Ngày tải lên: 17/03/2014, 23:20