Báo cáo y học: " Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding" pdf

... Santagostino E, Morfini M, Rocino A, Baudo F, Scaraggi FA, Gringeri A: Relationship between factor VII activity and clinical efficacy of recombinant factor VIIa given by continuous infu- sion in patients ... properly cited. Abstract Introduction Recombinant activated factor VII (rFVIIa) has been used as adjunctive therapy in trauma patients with severe bleeding...

Ngày tải lên: 13/08/2014, 01:20

... cells play an important role in protection against intracellular pathogens. Eliminating CD8+ T lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia, ... the change of CD8+ cell subsets during early period of ART. In this study we investigated the dynamic changes not only in CD8+ cell subsets, but also in their activation and...

Ngày tải lên: 10/08/2014, 05:22

... are activated by thrombin, whereas PAR-2 is activated mainly by trypsin but also by mast cell tryptase. PARs are expressed by several cell types, includ- ing platelets and endothelial and inflammatory ... play a key role in the catabolic and inflammatory pathways that take place during OA by inducing the synthesis of major catabolic and inflammatory mediators via the p38 and p42/44 si...

Ngày tải lên: 09/08/2014, 10:22

... solutions with increasing ethanol concentration, the specimens were incubated in xylene and finally embedded in paraffin wax. For in situ hybridization, paraffin-embedded samples were cut into slices ... amplification. Finally, the signals were detected with Cy5-labeled streptavidin (Dianova). Nuclear staining was again performed with 4,6-diamidino- 2-phenylindole. The sections we...

Ngày tải lên: 09/08/2014, 06:22

... and dimethyloxaloylglycineEffects of 2-methoxyestradiol and dimethyloxaloylglycine. Effects on synovial tissue, levels of hypoxia-inducible factor (HIF) 1α and viability of chondrocytes, and ... Induction of osteoarthritis by 2-methoxyestradiol demonstrates the importance of HIF-1 in maintaining the integrity of hypoxic articular cartilage. Stabilization of HIF-1 by dimethy...

Ngày tải lên: 09/08/2014, 13:22

... very common association of dysglycemia with coronary artery disease, since whe n including the previously and newly diagnosed patients, a total of 80% of all patients undergoing CABG have dysglycemia. Our ... that dysglycemia irrespective of underlying history of dia- betes is associated with adverse outcome in CABG patients, including longer hospital stay, wound infection...

Ngày tải lên: 10/08/2014, 09:22

... denervation in peroneus longus and peroneus b revis muscles plus finding of impaired sensory response of SPN. In case of APN these findings are accompanied by denervation potentials in EDB [6 ,7]. ... stu- dies” [2]. Marciniak study indicated 74% of patients had bilat- eral type of APN [17], which is more than our result (35%). Bilateral ADPN in this study was higher in...

Ngày tải lên: 10/08/2014, 10:20

... is usually caused by a high energy trauma. In this case it is possible that trauma energy was rotational and totally absorbed by the femoral shaft due to the lack of motion at the dysplastic ... stiff- ness with concomitant severe hip arthritis. She had fallen in her house while walking. On clinical examination, the leg was in fixed flexion with adduction and internal rotatio...

Ngày tải lên: 11/08/2014, 03:20

... a satisfactory clinical result. Introduction Femoral shaft fractures are usually high energy traumas, with significant blood loss and pain. These injuries are best treated by closed intramedullary ... close-locked intramedullary nailing [5]. In this case there was concern about the technical difficul- ties of antegrade nailing due to the distorted anatomy and the limited ability of in...

Ngày tải lên: 11/08/2014, 06:23

... following induction with LPS Despite recent interest in IL-17, a key cytokine involved in a variety immune responses, including the induction of other cytokines, its production from macrophages in the ... certain proinflammatory cytokine responses in a parasite-specific manner, however it augments the production of other proinflammatory cytokines. Our findings highlight the comp...

Ngày tải lên: 11/08/2014, 08:22