... gelatinases(MMP-2 and -9) have also been found in chondrocytes or the articular cartilage surface in OA [29,31]. The activity of many MMPs increases in OA by either an increase in theirown synthesis, an increased ... IL-1 and TNF-α [29–31,36]. NO may be involved in cartilage catabolism by inhibiting the synthesis of colla-gen and PG, enhancing MMP activity, reducing the synthe-sis of an IL-1 receptor antagonist ... through the attenuation of prosta-glandin E2(PGE2) and bradykinin synthesis, since HAinhibited their synthesis in a MW-dependent manner [16].Further, HA has been shown to induce analgesia in...