Báo cáo y học: "Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]" docx

... rheumatologist answered a questionnaire inquiring about the initial symptoms as reported by the patient (type of initial joint symptoms, localization and distribution of initial joint symptoms, ... patients and anti- CCP-positive patients was similar at 118 min and 123 min, respectively. In both groups symptoms started with pain and swelling, predominantly symmetrical and in the...

Ngày tải lên: 09/08/2014, 06:23

... Bacterial endotoxins and proinflammatory cytokines up-regulate ADM gene expres- sion in many tissues, both in vitro and in vivo in rodents and humans [38,39]. In addition, a decreased clearance by the ... Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors...

Ngày tải lên: 12/08/2014, 23:24

... of heroin, diazepam, ‘street’ methadone and cocaine. Heroin and cocaine were both smoked and injected intravenously. Frequency of use was difficult to clarify. Abdominal pain continued intermittently ... abdominal pain and fever. A presumptive diagnosis of urinary tract infection was made with laboratory investigations demonst rating a raised C-reactive protein and peripheral leuk...

Ngày tải lên: 11/08/2014, 14:21

... abdominal pain and fever. A pre- sumptive diagnosis of urinary tract infection was made with laboratory investigations demonstrating a raised C- reactive protein and peripheral leukocytosis, and ... contributions BCR and LAJ were the principal contributors to the man- uscript, and primarily involved in the care of the baby. DKMP and AGH performed the postmortem and kindly pr...

Ngày tải lên: 11/08/2014, 14:21

... erythematosus patient. Anti-angiotensin-con- verting enzyme (ACE) 2 antibodies and ACE activity in a systemic lupus erythematosus patient (SLE) before and after therapy. (a) The ELISA score and ... which may induce vasculopathies in patients with underlying disease such as CTD. Vasodilating drugs - including prostanoids, endothelin-receptor antagonists, and phosphodiesterase type-...

Ngày tải lên: 12/08/2014, 12:20

... by great variability in blood levels caused by nonlinear pharmacokinetics, polymorphism of cytochrome CYP2C19, drug-drug interactions and hepatic dysfunction [75-77]. Monitoring of circulating ... A recent, randomized, double-blind study comparing micafungin (100 or 150 mg/day) and caspofungin (70 mg loading dose and then 50 mg/day) in 595 adult patients with candidaemia or invasive...

Ngày tải lên: 13/08/2014, 08:21

... the redundancy in the inflammatory pathways. Other pathways and cytokines may activate and/ or inhibit the system at the same point, and different mediators may function as co- determinants of the inflammatory ... employed to identify immune cell surface markers (HLA-DR); expression of pro- inflammatory and anti-inflammatory mediators at the immune cell level (intracellular cytokin...

Ngày tải lên: 13/08/2014, 11:22

... re-analyses include the ability to check the statistical assumptions of regression models, to reanalyse the data using intention -to- treat analysis, and to include patients inappropriately excluded ... include the ability to undertake sufficiently powered exploratory subgroup analyses whilst avoiding the ecologic fallacy, to adjust for differences in baseline risk, to analyse...

Ngày tải lên: 13/08/2014, 11:22

... muscles, including ventilatory muscles, are broken down to provide amino acids for molecules needed in the inflammatory response. A major cytokine in the sepsis cascade is TNF-α. This cytokine produces ... inflammatory processes and cancer, and was actually originally called ‘cachexin’ [103]. TNF-α increases breakdown of myosin heavy chains in muscle cells in culture, which is e...

Ngày tải lên: 13/08/2014, 11:23

... tyrosine kinase receptor Tie2. Ligand binding to the extracellular domain of Tie2 results in receptor dimerization, autophosphorylation, docking of adaptors and coupling to intracellular signalling pathways. ... pneumonia, suggesting the existence of inflam- matory reactions for which Ang-2 is not mandatory. Ang-2 sensitizes ECs to activation by inflammatory cytokines. In Ang-2-d...

Ngày tải lên: 13/08/2014, 11:23