Báo cáo y học: " Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome" pot

... subsequently included in stepwise logistic regression. In some cases the moderately deficient protein C and normal protein C classes were combined for analysis of mortality by baseline protein C activity ... categorized by baseline protein C (n = 1574). Deficiency was categorized as: severe deficiency, protein C levels ≤ 40% of normal protein C activity (n = 61...

Ngày tải lên: 12/08/2014, 23:24

... daily changes in pro- tein C. Conclusion In summary, the current study confirmed that baseline protein C levels are an independent predictor of outcome in severe sepsis patients. Early changes in ... survival curves based on baseline and day 1 protein C activity levelsPROWESS 28-day survival curves based on baseline and day 1 protein C activity levels. Baseline...

Ngày tải lên: 12/08/2014, 23:24

... baseline PC levels and early changes in PC were prognostic of outcome. Change in PC levels on the first day after diagnosis of severe sepsis was highly correlated with outcome, with a decrease ... of Recombinant Activated Protein C; IL = interleukin; IQR = interquartile range; LOCF = last observation carried forward; PC = protein C; PROWESS = Recombinant Human Activated...

Ngày tải lên: 13/08/2014, 08:21

... hour) and longer infusion times (up to 7 days), and the efficacy of these infusions for normalization of protein C levels. We agree that these are clinical scenarios in which protein C may have ... end-point, there should be some plausible mechanism by which treatment influences the surrogate end-point. The mechanism by which DrotAA influences protein C levels is not entirely...

Ngày tải lên: 13/08/2014, 10:20

... Briesen H: Individual cell analysis of the cytokine repertoire in human immunodeficiency virus-1- infected monocytes/macrophages by a combination of immunocytochemistry and in situ hybridization. ... statistical significance (p = 0.22). Fairly convincing evidence of a significant increase in absolute CD4+ leukocyte count following treatment with GM-CSF comes from the phase III randomize...

Ngày tải lên: 11/08/2014, 10:23

... 1 Pediatric modified pRIFLE criteria for AKI using changes in estimated creatinine clearance pRIFLE stratum Change in eCCl Risk (R) eCCl decrease by 25% from baseline renal function Injury (I) eCCl ... Ronco C, Warnock DG, Levin A, the Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007, 11:R...

Ngày tải lên: 13/08/2014, 08:20

... GR, MR and BDNF levels were determined immunocytochemically. 5-HT1A receptors were quantified by in vitro binding autoradiography. Circulating leptin levels, following a chronic forced swimming ... handling-induced increase in hippocampal GR/MR ratio and BDNF levels. The handling-induced changes in BDNF and 5-HT1A receptors could underlie the previously documented effect of handling...

Ngày tải lên: 08/08/2014, 21:20

... GGC TCT CAC AGG ACG TGA AGC C- 3' and 5'-GGC TTC ACG TCC TGT GAG AGC CAA ATT G-3' for the M5 mutant; 5'-ATT CAC TCT GGT CAA GGT GCA GC-3' and 5'-GCT GCA CCT TGA CCA ... enzyme. The novel role of IN over 2-LTR circle junctions accounts for the pleiotropic effects observed in cells infected with IN mutants. It may explain why 1) 2-LTR circles accumulate in...

Ngày tải lên: 13/08/2014, 09:21

... impor- tant consequences on brain cells and function. In endo- toxic animals, microcirculatory failure occurred in the early phase of sepsis, and preceded changes in evoked potential responses, indicating ... PaO 2 /FiO 2 ratio and thoracopulmonary compliance decreased, indicating sepsis-related pulmonary dysfunc- tion. Finally, lactic acidosis and refractory hypotension occurred in...

Ngày tải lên: 13/08/2014, 21:21

... different LPS -concentrations and standardized reproducible hydrodynamic conditions in an otherwise unchanged comparative model to investigate the mechanisms of leukocyte accumulation during different ... leukocyte integrins such as lymphocyte function a ntigen-1 (LFA-1, CD11a/CD18) and macrophage antige n-1 (MAC-1, CD11b/CD18). Local activation of integrins favours interactions with end...

Ngày tải lên: 13/08/2014, 21:21