... smoking history by measuring seruminterleukine-6, C-reactive protein, and tumor necrosis factor. Expression of perforin, granzyme B, and FasL protein by CD8+ T lymphocytes, CD4+ T lymphocytes, ... (black), and emphysematous smokers (grey).Perforin and granzyme B protein expression by peripheral CD56+, CD3+, CD4+, and CD8+ cellsFigure 4Perforin and granzyme B protein expression by peripheral ... (TNF), and C-reactive protein (CRP) in smokers with emphysema, smokers without emphysema, and in non smokers with normal lung function. Expres-sion of perforin, granzyme B, and FasL protein by systemicT...