Báo cáo y học: " Rescue therapy in septic shock – is terlipressin the last frontie" ppt

... pharmacies dispense lysine vasopressin, or terlipressin (Glypressine ® ; Ferring Company, Berlin, Germany), which is the form of vasopressin that is present in pig. The first clinical trial evaluating the ... report their experience with terlipressin in 16 children with refractory septic shock. Over the past few years there has been much interest in the use of terl...

Ngày tải lên: 12/08/2014, 23:23

... a very early stage. Selecting candidates for TNF blockade therapy Identifying patients who benefit the most from TNF-blocking therapy is a reasonable strategy for optimising the use of these ... methotrexate alone in preventing progressive joint destruction, improving clinical responses and reducing disability in early disease. The additional benefit of biological therapy i...

Ngày tải lên: 09/08/2014, 10:20

... fuzzy logic principles to modify intravenous norepinephrine (noradrenaline) infusion rates during norepinephrine infusion in septic patients in order to reduce the duration of shock. Methods Septic ... the studyKaplan-Meier curves demonstrating the probability of being on nore- pinephrine therapy during the study. Comparisons between the time distribution of both groups...

Ngày tải lên: 13/08/2014, 11:23

... purposes) finding may be explained by the less severe septic shock at the time of treatment initiation (drop in MAP of 10% in the present study vs. 30% in the latter study) and is in line with the results ... first-line therapy, even in doses higher than currently recommended by the guidelines of the Surviving Sepsis Campaign [13], might be superior to a last-...

Ngày tải lên: 13/08/2014, 18:22

... glance, the study by Abboud and colleagues confirms the few existing reports on catecholamine kinetics in critically ill patients with variable underlying pathology. Nevertheless, some intriguing ... particularly compromised in the most severely diseased patients. Hence, the reason(s) for the well- known extreme variability in catecholamine pharmaco- dynamics remain to be eluc...

Ngày tải lên: 13/08/2014, 18:22

... AVP simultaneously with catecholamines rather than using AVP alone [13]. In fact, we found during long-term, resuscitated hyperdynamic porcine fecal peritonitis that combining noradrenaline with AVP to maintain ... systemic hemodynamic endpoints. What do we learn from Müller and colleagues’ findings? In this context, the experimental design must be taken into account. The model per se...

Ngày tải lên: 13/08/2014, 08:21

... convincingly supports the application of gene therapy in RA, and the feasibility of gene therapy was recently demonstrated in phase I clinical trials. Keywords: arthritis, cytokines, gene therapy, ... genetic synovectomy, and it is the latest development in the tradition of synovectomy, as performed surgically, chemically or by radiation therapy. In RA the fibroblast...

Ngày tải lên: 09/08/2014, 01:24

... doses of infliximab. One can then postulate that this particular induction is due to the partial blockage of TNF-α induced by infliximab therapies. The role of the disturbance of the cytokine network ... complement- dependent cellular cytotoxicity of the cells expressing the cytokine [37]. Furthermore, infliximab has been shown to increase the number of apoptotic T lymphocytes...

Ngày tải lên: 09/08/2014, 01:24

... specifically for the purpose. However, it remains that the observation described in this study may be important in the clinical context. Methotrexate may be the most appropriate first-line DMARD therapy ... homocysteine levels [51]. This may be particularly important in the context of the MetS, which is known to be associated with high homo- cysteine levels [52]. Insulin...

Ngày tải lên: 09/08/2014, 14:22

... because procoagulatory activity may limit the inflammatory process in the early stages of ALI. Second, the frequency of bleeding complications might be decreased by inhalational administration of rhAPC. This local ... group. The essential question is, why do promising treatment strategies tested in experimental models often fail in randomized, clinical trials? Is the ineffi...

Ngày tải lên: 13/08/2014, 11:22