Báo cáo y học: " Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes" potx

... may play roles in cell-to-cell transmission beyond the recruitment of Gag. It will be of interest to address whether host cell factors known to interact with the Env-CT, such as the recently ... medium, provided the original work is properly cited. Research Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission b...

Ngày tải lên: 12/08/2014, 23:23

... plastocyanin with cytochrome f and analysed the reaction of these mutants with the soluble redox-active domain of cytochrome f (Cyt f) in vitro.This paper presents results on the interaction in vitro between ... than that of wild-type or the other mutants, indicating that in addition to the electrostatic effect, which leads to low rates at low ionic strength, another...

Ngày tải lên: 21/02/2014, 01:21

... PSII activity in hf-2 compared with that of the wild-type is therefore neither due to the change in peptide composition of the PSII complex nor to the ultrastructure of thylakoid membranes. The ... lower rate of photosystem II (PSII) activity by  40% and also a lower growth rate than those of the wild- type. Results of genetical analysis of hf-2 strongly suggest...

Ngày tải lên: 22/02/2014, 04:20

... The different mutants are indicated in the box on the top right. The scale for the velocity of the mutants is indicated on the left side and that for the wild-type enzyme on the right side. The assay conditions ... results implicate that the Na + binding of the decarboxylase (K m % 1m M ) was dramatically affected by the S382A mutation. We also investigated the...

Ngày tải lên: 08/03/2014, 23:20

... observed for Y2 38 mutants with the ligands tested (Table 2). These results indicate that the mode of ligand binding is retained in the two mutants, and that the alteration of the spectral effects can ... lysine, glutamine, aspartate, and alanine [10]. The perturbation of the active site in the R285 mutants modifies the precise substrate alignment: alteration of...

Ngày tải lên: 17/03/2014, 17:20

... on the nature of this intermediate. The detailed implications of these data are discussed below. Examination of the electronic spectra for the two variants indicates that large-scale structural ... which is in approximate agreement with the limiting rate constant of 4.3 s )1 determined above. The maximum concentration of the intermediate under these conditions was 91...

Ngày tải lên: 18/03/2014, 01:20

... protection against EIB during the first 3 days of treatment with either montelukast or salmeterol, but again, the pro- tection was lost in the salmeterol group after 4 weeks of treatment. Protection was ... potent. 5 The cysteinyl leukotrienes exert their biologic effects by binding to cysteinyl leukotriene receptors (specifically Review Article Role of Leukotriene Receptor...

Ngày tải lên: 08/08/2014, 20:23

... 2-methoxyestradiol demonstrates the importance of HIF-1 in maintaining the integrity of hypoxic articular cartilage. Stabilization of HIF-1 by dimethyloxaloylglycine, however, was not of therapeutic ... center of the forming car- tilaginous elements [1]. On the contrary, another study in mice with conditional inactivation of the von Hippel–Lindau protein demonstrated...

Ngày tải lên: 09/08/2014, 13:22

... mice with nephritis [20,21], suggesting that STAT1 may play a role in the pathogenesis of SLE. A possible role of SNPs in the STAT1-STAT4 region other than the haplotype tagged by rs757486 5T has ... Expression of STAT4β, lacking the transactivation domain, did not appear to be affected by the STAT4 single nucleotide polymorphisms (SNPs) [13]. STAT1, another member...

Ngày tải lên: 09/08/2014, 13:22

... plexus of the enteric nervous system in the stomach. Taurinergic neurons in the muscle layer of the gastrointestinal (GI) tract might be involved in motility of the GI tract and the function of endocrine ... sig- nificant effect on the taurine-induced acid secretion. This suggests tha t histamin e and gas tri n may not parti- cipate in these events. TTX complet...

Ngày tải lên: 10/08/2014, 05:21