Báo cáo y học: " Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody" ppsx

... interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody Retrovirology 2010, 7:38 Willett et al. Retrovirology 2010, 7:38 http://www.retrovirology.com/content/7/1/38 Page ... the virus- receptor interaction may not simply be a modulation of binding affinity, rather it cou...

Ngày tải lên: 12/08/2014, 23:23

... mutation in the p51 subunit of HIV-1 RT [55]. The introduction of this mutation into RT significantly diminishes the ability of TSAO to bind to and inhibit the enzyme [55] and accordingly TSAO-e 3 T ... (discussed below). Peptide-based inhibitors of PR dimerization Short synthetic peptides corresponding to the amino-acid sequences of the N- and C-termini of HIV-1 PR h...

Ngày tải lên: 08/03/2014, 09:20

... Berlin, Germany). The phase contain- Figure 1 Inhibition of leukocyte interaction with the postcapillary endothelium by ALP in vivoInhibition of leukocyte interaction with the postcapillary endothelium ... by ALP in vivo. (a) Inhibition of leukocyte rolling along the postcapillary endothelium by antileukoproteinase in vivo. The results show the frac- tion...

Ngày tải lên: 09/08/2014, 08:22

... molecule is inserted into the virus while the other is anchored into the cellular membrane. (B) Tethering by incorporation of one of the molecule anchors in the virus and the other in the cellular ... resistance displayed by the chimpanzee Tetherin to the Vpu protein originating from the SIVgsn/mon/ mus lineage results from the high sequence variabili...

Ngày tải lên: 13/08/2014, 01:20

... Since apoptosis mediated by Tat partly relies on the interaction of Tat with tubulin [14-17], we hypothesized that zinc binding might play a role in the modulation by Tat of the microtubule dynamics. Thus, ... reversibility of the major part of the holo-Tat-induced turbidity increase at 10°C indicate that holo-Tat mainly induces the formation of microtubules. A...

Ngày tải lên: 13/08/2014, 05:21

... (h) Time in YPD (min) Time in SPM (h) Time in YPD (min) Time in SPM (h) Time in YPD (min) Time in SPM (h) Time in YPD (min) Time in SPM (h) Time in YPD (min) Time in SPM (h) Time in YPD (min) http://genomebiology.com/2006/7/3/R20 ... genes Time in SPM (h) Time in YPD (min) Time in SPM (h) Time in YPD (min) Time in SPM (h) Time in YPD (min) Time in SPM (h) T...

Ngày tải lên: 14/08/2014, 16:21

... as measured by the AIM-C, was also generally improved over the course of the study. At baseline, most caregivers indicated inconsistency in their child's behavior across the day in contrast ... social interactions since beginning the study medication, and 91.9% were satisfied with the efficacy of the study medi- cation on their child's attention. The majori...

Ngày tải lên: 25/10/2012, 10:06

... that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the ... previously that G/G of the PTPN11 gene encoding SHP-2 increased the risk of gastric atrophy among the seropositive subjects [18]. The present study examined the associat...

Ngày tải lên: 31/10/2012, 15:37

... increase from the apoenzyme to the Mn 2þ -containing enzyme, loss of the metal cofactor could be the limiting step in BLXI inactivation. Higher E a values of inactivation for the Co 2þ – enzyme and the ... on xylose, the apoenzyme activity was tested on both sugars in the presence of increasing concentrations of each cation (in the chloride form; Fig. 4). In...

Ngày tải lên: 22/02/2014, 07:20

... high conservation of the sequences forming the pin in th e majority of bacteria with the exception of two Mycoplasma species and one of Ureaplasma. In t he RuvA p roteins from these organisms the pin sequence ... Holliday junction and allow subsequent loading of RuvB and RuvC. A negatively charged pin pro- jecting from th e centre limits b inding of linear duplex D...

Ngày tải lên: 17/03/2014, 17:20