Báo cáo y học: " Host hindrance to HIV-1 replication in monocytes and macrophages" doc

... APOBEC3G is incorporated into HIV-1 virions and deaminates dC to dU in minus single- strand nascent cDNA within newly infected cells; result- ing in lethal G -to- A hypermutations in the single stranded ... deoxythymidine triphosphate (dTTP), associated with low levels of thymidine phosphorylase, the enzyme that converts thymine into thymidine [27]. Both dTTP and thymidine phosp...

Ngày tải lên: 12/08/2014, 23:23

... and injured cells. In addition to internal pathways that trigger apoptosis mainly in response to cytotoxic stress, apoptosis can be induced through cell surface death receptors that contain molecu- lar ... FasL induced apopto- sis. Our findings point to yet unconsidered effects of mod- ulating proinflammatory cytokines that must be taken into account when novel biological agents s...

Ngày tải lên: 09/08/2014, 01:23

... Papa N, Cinquini M, Magrini L, Tin- cani A, Valesini G: Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFalpha therapy (infliximab) in rheumatoid arthritis ... American College of Rheumatology criteria [27] with progressive erosive disease, including large joint involvement, and were refractory to com- bination therapy with DMARDs and,...

Ngày tải lên: 09/08/2014, 10:21

... (CIA) and experimental autoimmune encephalomyelitis (EAE) using myelin and synovial antigen arrays. (a, b) Synovial and (d, e) myelin arrays were produced by printing synovial and myelin peptides ... reactivity against epitopes derived from MBP, myelin oli- godendrocyte glycoprotein (MOG), myelin-associated glycoprotein, myelin-associated oligodendrocyte basic protein and αB-crysta...

Ngày tải lên: 09/08/2014, 13:22

... The obtained specimens were fixed in formalde- hyde. Immunohistology The fixed biopsies were embedded in paraffin, stained with Masson's trichrome and hematoxylin-eosin and examined by light ... image interpretation The scans were evaluated by two independent radiologists blinded to clinical data, multi-slice computed tomogra- phy, coronary angiography and biopsy results in...

Ngày tải lên: 10/08/2014, 10:20

... Access Hemangioma related to Maffucci syndrome in a man: a case report Takeshi Kondo Abstract Introduction: Maffucci syndrome is a rare clinical entity (app roximately 200 cases have been reported in the medical ... hemangiomas was removed and examined pathologically. The morphological picture was an admixture of cavernous hemangioma and spindle cell hemangioma without cytological a...

Ngày tải lên: 10/08/2014, 23:21

... eruption and inhaled tiotropium bromide. Dermatology 2007, 214:97-98. 4. Guillot B: Skin reactions to inhaled corticosteroids. Clinical aspects, incidence, avoidance, and management. Am J Clin Dermatol ... patient to avoid using tio- tropium in the future and prescribed a 9 μg formoterol inhalation capsule twice a day ; this medication was well tolerated and effective. Conclusio...

Ngày tải lên: 11/08/2014, 00:23

... more positive and excited symptoms than patients given pre- scriptions for monotherapy [48]. Additionally, the find- ings support clinicians’ reports of using po lypharmacy for refractory psychotic symptoms ... collected by routine clinical intervi ew by a psychiatrist every six months, and relapse was defined using information regarding the baseline characteristics of the patient. Additi...

Ngày tải lên: 11/08/2014, 16:23

... of primary HIV envelopes from brain and lymphoid tissues to examine the relationship between neutralization sensitivity to reagents targeting the CD4 binding site and virus entry into macrophages. Neutralization ... conformation, density, and affinity in HIV-1 infec- tion. Virology 2000, 276:229-237. 5. Berger EA, Murphy PM, Farber JM: Chemokine receptors as HIV- 1 coreceptors:...

Ngày tải lên: 12/08/2014, 23:21

... Editing of double-stranded RNAs Many double-stranded RNAs (dsRNAs) in cells, especially those in the nucleus, are susceptible to base editing in which adenosines are deaminated to inosines by enzymes ... containing edited Alu sequences, and certainly those with edited intronic Alus, might remain in the nucleus and thus not interfere with normal gene expression. An intriguing...

Ngày tải lên: 14/08/2014, 14:21