... Therapy Vol 10 No 5 Drexler et al. evidence implicating certain signalling pathways in driving the continuous production of pro-inflammatory mediators in the RA joint. The danger signal hypothesis The ... lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 1994, 264:1319-1322. 69. Page TH, Smolinska MJ, Gillespie J, Urbaniak AM, Foxwell BM: Tyrosine kinases a...
Ngày tải lên: 09/08/2014, 10:23
... annual symposium of the Protein Society highlighted the dynamic motions that enable almost all protein function. The ability of polypeptide protein chains to adopt intricate and highly-defined ... polariza- bility at multiple positions within staphylococcal nuclease. Polarizability was determined by introducing ionizable amino acids and measuring their pK a shift. The data obtained fro...
Ngày tải lên: 09/08/2014, 20:20
Báo cáo y học: "Terrorist bombings in Madrid" potx
... as current events, namely bombings and shootings, with bodily injury the most likely result. In fact, a state-wide system has already been implemented on this principle in Connecticut, using the state-wide ... terrorist bombing disasters, and lends itself to quality improvement analysis. The authors should be commended for applying the established objective measures of injury severity (In...
Ngày tải lên: 12/08/2014, 20:20
Báo cáo y học: "Myocardial protection in sepsis" potx
... myocardial infarction were reduced. Hypotension was very instrumental in causing the adverse events. Interestingly, sepsis and infection were also clearly more common on metoprolol. Commentary Myocardial ... offset by an increase in cardiogenic shock (11 per 1,000) [7]. This was most prominent in the first day of therapy in elderly patients with tachycardia and low blood pressure, a p...
Ngày tải lên: 13/08/2014, 11:22
Báo cáo y học: "Cerebral perfusion in sepsis" pot
... brain function in sepsis. Sepsis and the brain In sepsis, the brain may be aff ected by many systemic disturbances, such as hypotension, hypoxemia, hyper- glycemia, hypoglycemia, and organ dysfunction ... brain and regulates brain capillary blood fl ow [1]. In sepsis, cerebral endothelial cells are activated by lipopoly- saccharide (LPS) and pro -in ammatory cytokines, including bradyk...
Ngày tải lên: 13/08/2014, 20:21
Báo cáo y học: "Maize genome in motion" potx
... parent-of-origin imprinting impacting on gene expression during early post- fertilization development; and the link between DNA methy- lation and transposon silencing by Vicki Chandler and myself in 1986. ... maize genome. In this preliminary analysis of the draft genome sequence by Josh Stein (MGSC, Cold Spring Harbor Laboratory, Cold Spring Harbor, USA) it is clear that just the gypsy f...
Ngày tải lên: 14/08/2014, 08:21
Báo cáo y học: " Design, assembly, and validation of a nose-only inhalation exposure system for studies of aerosolized viable influenza H5N1 virus in ferrets" ppt
... viruses. In 6th International symposium on aerobiology, Airborne transmission and airborne infections Edited by: Hers JF, Winkles KC. New York:Wiley; 1973:175-182. 29. Shinya K, Ebina M, Yamada S, ... three impingers.* Virus Conc. (TCID 50 /ml) in BANG reservoir Virus quantity in impinger A (TCID 50 units) Virus quantity in impinger B (TCID 50 units) Virus quantity in im...
Ngày tải lên: 12/08/2014, 04:20
Báo cáo y học: " Intracellular assembly and budding of the Murine Leukemia Virus in infected cells" pps
... wort- mannin on the localisation of lysosomal type I integral mem- brane glycoproteins suggests a role for phosphoinositide 3- kinase activity in regulating membrane traffic late in the endocytic ... lysis. The level of this intracellular activity is probably underestimated since virus particles contained in cell lysate could be damaged by the lysis procedure. Lysate obtained from mock-...
Ngày tải lên: 13/08/2014, 09:21
Báo cáo y học: " Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene therapy" pps
... siRNA-directe- dinhibition of HIV-1 infection. Nat Med 2002, 8:681-686. 45. Qin XF, An DS, Chen IS, Baltimore D: Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering ... weekly by digesting with colla- genase IV as previously described [5]. A VSV-G pseudo- typed lentiviral vector (SINF-EF1a-GFP) containing a GFP reporter gene (kindly supplied...
Ngày tải lên: 13/08/2014, 09:21
Báo cáo y học: " Regional coordination in medical emergencies and major incidents; plan, execute and teach"
... planning, teaching and training responsibilities offers possibilities for planning, teaching and training disaster medicine by giving immediate feed- back based on real incidents. Background Introduction To ... be included in the risk assessment regarding possible major incidents in this region. The purpose of this study was to find whether this institution has achieved its primary tasks...
Ngày tải lên: 25/10/2012, 09:56